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FGF18 FGF18 IRS1 IRS1 FGF9 FGF9 FGF10 FGF10 ATP6V1C1 ATP6V1C1 KRAS KRAS FGF1 FGF1 PIK3R2 PIK3R2 TLR9 TLR9 ENSMLEP00000002144 ENSMLEP00000002144 SPEM1 SPEM1 TCIRG1 TCIRG1 FLT3LG FLT3LG ATP6V1H ATP6V1H LIM2 LIM2 ATP6V1E2 ATP6V1E2 ATP6V0E2 ATP6V0E2 PTPN1 PTPN1 ATP6AP1 ATP6AP1 PTPN11 PTPN11 FGF23 FGF23 ERAS ERAS FGFR2 FGFR2 FGFR4 FGFR4 ATP6V1C2 ATP6V1C2 FGF20 FGF20 ATP6V1G2 ATP6V1G2 IFITM10 IFITM10 ATP6V1A ATP6V1A FGF16 FGF16 FGF5 FGF5 FGF2 FGF2 ENSMLEP00000017851 ENSMLEP00000017851 GRB2 GRB2 INSR INSR GAB1 GAB1 INS INS CNST CNST LOC105533912 LOC105533912 ATP6V0D2 ATP6V0D2 ENSMLEP00000014760 ENSMLEP00000014760 GAB4 GAB4 ENSMLEP00000013771 ENSMLEP00000013771 PDE3B PDE3B ATP6V0D1 ATP6V0D1 FGF17 FGF17 ATP6V1B2 ATP6V1B2 FGF19 FGF19 HRAS HRAS SHC1 SHC1 PIK3R4 PIK3R4 THEM4 THEM4 ENSMLEP00000035415 ENSMLEP00000035415 ATP6V0A4 ATP6V0A4 TRIB3 TRIB3 GRB10 GRB10 PIK3R1 PIK3R1 FGF7 FGF7 IDE IDE KL KL ATP6V1B1 ATP6V1B1 FRS2 FRS2 ATP6V1D ATP6V1D NRAS NRAS GAB2 GAB2 FGF8 FGF8 CTSD CTSD NRDC NRDC ATP6V0A2 ATP6V0A2 KLB KLB ATP6AP1L ATP6AP1L ENSMLEP00000028290 ENSMLEP00000028290 PIK3CB PIK3CB ENSMLEP00000027485 ENSMLEP00000027485 ENSMLEP00000027162 ENSMLEP00000027162 ATP6V1F ATP6V1F FLT3 FLT3 SPEM2 SPEM2 ATP6V1G1 ATP6V1G1 ATP6V1E1 ATP6V1E1 FGF6 FGF6 MAPK1 MAPK1 ATP6V1G3 ATP6V1G3 ATP6V0C ATP6V0C FGF3 FGF3 AKT2 AKT2 SOS1 SOS1 MAPK3 MAPK3 ENSMLEP00000021070 ENSMLEP00000021070 PIK3CA PIK3CA ATP6V0B ATP6V0B ENSMLEP00000013122 ENSMLEP00000013122 FGFR3 FGFR3 ENSMLEP00000012128 ENSMLEP00000012128 ATP6V0E1 ATP6V0E1 PDPK1 PDPK1 ATP6V0A1 ATP6V0A1 PTPRF PTPRF FGFR1 FGFR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PIK3R2Uncharacterized protein. (587 aa)
TLR9TIR domain-containing protein. (1033 aa)
ENSMLEP00000002144V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (142 aa)
SPEM1Spermatid maturation 1. (309 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (199 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
LIM2Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (215 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
ATP6V0E2ATPase H+ transporting V0 subunit e2. (212 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (470 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (656 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
ERASES cell expressed Ras. (233 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (417 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (158 aa)
IFITM10Interferon induced transmembrane protein 10. (192 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (617 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
ENSMLEP00000017851V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (107 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
INSRTyrosine-protein kinase receptor. (1301 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CNSTConsortin, connexin sorting protein. (725 aa)
LOC105533912Uncharacterized protein. (218 aa)
ATP6V0D2ATPase H+ transporting V0 subunit d2. (306 aa)
ENSMLEP00000014760PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (94 aa)
GAB4GRB2 associated binding protein family member 4. (555 aa)
ENSMLEP00000013771PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (104 aa)
PDE3BPhosphodiesterase. (1113 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (392 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (498 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (308 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SHC1SHC adaptor protein 1. (584 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
THEM4Thioesterase superfamily member 4. (240 aa)
ENSMLEP00000035415Uncharacterized protein. (519 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (750 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
GRB10Growth factor receptor bound protein 10. (593 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
IDEInsulin degrading enzyme; Belongs to the peptidase M16 family. (1019 aa)
KLKlotho; Belongs to the glycosyl hydrolase 1 family. (645 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
ATP6V1DATPase H+ transporting V1 subunit D. (249 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GAB2GRB2 associated binding protein 2. (667 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (397 aa)
NRDCNardilysin convertase. (1219 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (822 aa)
KLBKlotho beta. (1044 aa)
ATP6AP1LATPase H+ transporting accessory protein 1 like. (223 aa)
ENSMLEP00000028290Uncharacterized protein. (441 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ENSMLEP00000027485PID domain-containing protein. (488 aa)
ENSMLEP00000027162Uncharacterized protein. (195 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (147 aa)
FLT3Fms related tyrosine kinase 3. (937 aa)
SPEM2SPEM family member 2. (506 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP6V1E1Uncharacterized protein. (204 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (124 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (128 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1299 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
ENSMLEP00000021070C2 PI3K-type domain-containing protein; Belongs to the PI3/PI4-kinase family. (201 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (255 aa)
ENSMLEP00000013122Uncharacterized protein. (179 aa)
FGFR3Fibroblast growth factor receptor. (771 aa)
ENSMLEP00000012128Uncharacterized protein. (234 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (529 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (775 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1913 aa)
FGFR1Fibroblast growth factor receptor. (853 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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