76 items (Mandrillus leucophaeus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	SIN3A	SIN3 transcription regulator family member A. (1273 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	ENSMLEP00000036527	Uncharacterized protein. (89 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	FOXO4	Forkhead box O4. (505 aa)
	ENSMLEP00000032494	Thioredoxin; Belongs to the thioredoxin family. (101 aa)
	ENSMLEP00000032219	Plexin_cytopl domain-containing protein. (255 aa)
	G6PC	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	ENSMLEP00000031869	CBFD_NFYB_HMF domain-containing protein. (183 aa)
	EP300	E1A binding protein p300. (2411 aa)
	SREBF1	Sterol regulatory element binding transcription factor 1. (1124 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
	GCK	Phosphotransferase. (466 aa)
	PINK1	PTEN induced kinase 1. (545 aa)
	NFYC	Nuclear transcription factor Y subunit gamma. (439 aa)
	RBL2	RB transcriptional corepressor like 2. (1139 aa)
	AKT1	Non-specific serine/threonine protein kinase. (432 aa)
	LOC105529488	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (458 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
	BCL6B	BCL6B transcription repressor. (475 aa)
	SMAD2	Mothers against decapentaplegic homolog. (457 aa)
	RETN	Resistin. (108 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (280 aa)
	SIRT3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (340 aa)
	BCL6	BCL6 transcription repressor. (708 aa)
	ATXN3	Ataxin 3. (340 aa)
	ENSMLEP00000017703	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (777 aa)
	GDF11	Growth differentiation factor 11. (345 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	IGFBP1	Insulin like growth factor binding protein 1. (260 aa)
	ENSMLEP00000015404	Fork-head domain-containing protein. (531 aa)
	FBXO32	F-box protein 32. (355 aa)
	KAT2B	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (778 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (236 aa)
	ABCA6	ATP binding cassette subfamily A member 6. (1573 aa)
	ENSMLEP00000013869	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (214 aa)
	KLF4	Uncharacterized protein. (145 aa)
	YWHAQ	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	NFYB	CBFD_NFYB_HMF domain-containing protein. (208 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (198 aa)
	TXN	Thioredoxin domain-containing protein. (83 aa)
	ENSMLEP00000008466	Josephin domain-containing protein. (133 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	PCBP4	Poly(rC) binding protein 4. (411 aa)
	FOXG1	Uncharacterized protein. (151 aa)
	TXNIP	Thioredoxin interacting protein. (391 aa)
	SIRT1	Sirtuin 1. (661 aa)
	ENSMLEP00000005144	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	BTG1	BTG anti-proliferation factor 1. (96 aa)
	TRIM63	Tripartite motif containing 63. (383 aa)
	LOC105528170	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (208 aa)
	LOC105544325	Thioredoxin; Belongs to the thioredoxin family. (101 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
	AGRP	Agouti related neuropeptide. (132 aa)
	FOXO3	Forkhead box O3. (670 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	CCNG2	Cyclin G2; Belongs to the cyclin family. (344 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
	PLXNA4	Sema domain-containing protein. (522 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (798 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (165 aa)
	NFYA	Nuclear transcription factor Y subunit alpha. (347 aa)
	LOC105540905	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
	CREBBP	CREB binding protein. (2423 aa)
	LOC105540906	14-3-3 protein sigma. (248 aa)
	POMC	Proopiomelanocortin. (265 aa)
	MSTN	Myostatin. (376 aa)
	LOC105545834	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (470 aa)
	YWHAZ	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGRP	ENSMLEP00000015404	ENSMLEP00000023415	ENSMLEP00000015404	Agouti related neuropeptide.	Fork-head domain-containing protein.	0.635
AGRP	FOXO3	ENSMLEP00000023415	ENSMLEP00000022014	Agouti related neuropeptide.	Forkhead box O3.	0.404
AGRP	INS	ENSMLEP00000023415	ENSMLEP00000016207	Agouti related neuropeptide.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.647
AGRP	POMC	ENSMLEP00000023415	ENSMLEP00000002362	Agouti related neuropeptide.	Proopiomelanocortin.	0.799
AKT1	AKT2	ENSMLEP00000027863	ENSMLEP00000021914	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.967
AKT1	AKT3	ENSMLEP00000027863	ENSMLEP00000036989	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.914
AKT1	CDKN1A	ENSMLEP00000027863	ENSMLEP00000011646	Non-specific serine/threonine protein kinase.	Cyclin dependent kinase inhibitor 1A.	0.970
AKT1	CDKN1B	ENSMLEP00000027863	ENSMLEP00000010603	Non-specific serine/threonine protein kinase.	Cyclin dependent kinase inhibitor 1B.	0.974
AKT1	CREBBP	ENSMLEP00000027863	ENSMLEP00000000887	Non-specific serine/threonine protein kinase.	CREB binding protein.	0.469
AKT1	ENSMLEP00000013869	ENSMLEP00000027863	ENSMLEP00000013869	Non-specific serine/threonine protein kinase.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.412
AKT1	ENSMLEP00000015404	ENSMLEP00000027863	ENSMLEP00000015404	Non-specific serine/threonine protein kinase.	Fork-head domain-containing protein.	0.984
AKT1	EP300	ENSMLEP00000027863	ENSMLEP00000031242	Non-specific serine/threonine protein kinase.	E1A binding protein p300.	0.789
AKT1	FOXG1	ENSMLEP00000027863	ENSMLEP00000005882	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.620
AKT1	FOXO3	ENSMLEP00000027863	ENSMLEP00000022014	Non-specific serine/threonine protein kinase.	Forkhead box O3.	0.975
AKT1	FOXO4	ENSMLEP00000027863	ENSMLEP00000032677	Non-specific serine/threonine protein kinase.	Forkhead box O4.	0.969
AKT1	INS	ENSMLEP00000027863	ENSMLEP00000016207	Non-specific serine/threonine protein kinase.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.512
AKT1	KLF4	ENSMLEP00000027863	ENSMLEP00000012468	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.416
AKT1	PPARGC1A	ENSMLEP00000027863	ENSMLEP00000020141	Non-specific serine/threonine protein kinase.	PPARG coactivator 1 alpha.	0.400
AKT1	SIRT1	ENSMLEP00000027863	ENSMLEP00000005263	Non-specific serine/threonine protein kinase.	Sirtuin 1.	0.404
AKT1	SMAD2	ENSMLEP00000027863	ENSMLEP00000027206	Non-specific serine/threonine protein kinase.	Mothers against decapentaplegic homolog.	0.540