19 items (Mandrillus leucophaeus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	KPNA1	Importin subunit alpha; Functions in nuclear protein import. (538 aa)
	CORO1B	Coronin; Belongs to the WD repeat coronin family. (489 aa)
	ACP1	Acid phosphatase 1. (158 aa)
	CORO2B	Coronin; Belongs to the WD repeat coronin family. (494 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (138 aa)
	ATP6V1H	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
	LOC105541098	Ubiquitin-like domain-containing protein. (156 aa)
	LOC105536598	Ubiquitin-like domain-containing protein. (156 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (461 aa)
	CORO1C	Coronin; Belongs to the WD repeat coronin family. (527 aa)
	RAB7A	RAB7A, member RAS oncogene family. (207 aa)
	CORO2A	Coronin; Belongs to the WD repeat coronin family. (525 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
	KPNB1	Karyopherin subunit beta 1. (874 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1147 aa)
	VPS33B	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (617 aa)
	CORO6	Coronin; Belongs to the WD repeat coronin family. (472 aa)
	HGS	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (815 aa)
	ENSMLEP00000010590	LMWPc domain-containing protein. (141 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CORO1A	CORO1B	ENSMLEP00000039716	ENSMLEP00000014030	Coronin; Belongs to the WD repeat coronin family.	Coronin; Belongs to the WD repeat coronin family.	0.651
CORO1B	CORO1A	ENSMLEP00000014030	ENSMLEP00000039716	Coronin; Belongs to the WD repeat coronin family.	Coronin; Belongs to the WD repeat coronin family.	0.651
CORO1B	CORO1C	ENSMLEP00000014030	ENSMLEP00000037995	Coronin; Belongs to the WD repeat coronin family.	Coronin; Belongs to the WD repeat coronin family.	0.801
CORO1B	CORO6	ENSMLEP00000014030	ENSMLEP00000022094	Coronin; Belongs to the WD repeat coronin family.	Coronin; Belongs to the WD repeat coronin family.	0.619
CORO1C	CORO1B	ENSMLEP00000037995	ENSMLEP00000014030	Coronin; Belongs to the WD repeat coronin family.	Coronin; Belongs to the WD repeat coronin family.	0.801
CORO6	CORO1B	ENSMLEP00000022094	ENSMLEP00000014030	Coronin; Belongs to the WD repeat coronin family.	Coronin; Belongs to the WD repeat coronin family.	0.619
HGS	LOC105536598	ENSMLEP00000008794	ENSMLEP00000008278	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Ubiquitin-like domain-containing protein.	0.896
HGS	LOC105541098	ENSMLEP00000008794	ENSMLEP00000004673	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Ubiquitin-like domain-containing protein.	0.896
HGS	RPS27A	ENSMLEP00000008794	ENSMLEP00000000914	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Ubiquitin-like domain-containing protein.	0.896
HGS	UBA52	ENSMLEP00000008794	ENSMLEP00000029249	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.752
KPNA1	KPNB1	ENSMLEP00000012044	ENSMLEP00000028255	Importin subunit alpha; Functions in nuclear protein import.	Karyopherin subunit beta 1.	0.991
KPNB1	KPNA1	ENSMLEP00000028255	ENSMLEP00000012044	Karyopherin subunit beta 1.	Importin subunit alpha; Functions in nuclear protein import.	0.991
LOC105536598	HGS	ENSMLEP00000008278	ENSMLEP00000008794	Ubiquitin-like domain-containing protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.896
LOC105536598	UBA52	ENSMLEP00000008278	ENSMLEP00000029249	Ubiquitin-like domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.990
LOC105541098	HGS	ENSMLEP00000004673	ENSMLEP00000008794	Ubiquitin-like domain-containing protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.896
LOC105541098	UBA52	ENSMLEP00000004673	ENSMLEP00000029249	Ubiquitin-like domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.990
RPS27A	HGS	ENSMLEP00000000914	ENSMLEP00000008794	Ubiquitin-like domain-containing protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.896
RPS27A	UBA52	ENSMLEP00000000914	ENSMLEP00000029249	Ubiquitin-like domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.990
UBA52	HGS	ENSMLEP00000029249	ENSMLEP00000008794	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.752
UBA52	LOC105536598	ENSMLEP00000029249	ENSMLEP00000008278	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Ubiquitin-like domain-containing protein.	0.990