STRINGSTRING
PPP4R1 PPP4R1 NFKB1 NFKB1 MAP2K3 MAP2K3 NLRP6 NLRP6 ENSMLEP00000011388 ENSMLEP00000011388 ATF1 ATF1 PPP2R1A PPP2R1A DUSP6 DUSP6 DUSP7 DUSP7 AGER AGER TLR10 TLR10 RPS27A RPS27A ENSMLEP00000001074 ENSMLEP00000001074 PELI3 PELI3 UBE2NL UBE2NL NKIRAS2 NKIRAS2 TRAF6 TRAF6 RPS6KA2 RPS6KA2 LOC105541098 LOC105541098 ENSMLEP00000005424 ENSMLEP00000005424 MAPKAPK2 MAPKAPK2 NFKB2 NFKB2 TIFA TIFA ENSMLEP00000006240 ENSMLEP00000006240 MAPK10 MAPK10 LRRC14 LRRC14 ECSIT ECSIT MAPK9 MAPK9 LOC105540679 LOC105540679 SKP1 SKP1 PELI1 PELI1 MAPK7 MAPK7 LOC105536598 LOC105536598 ENSMLEP00000008311 ENSMLEP00000008311 ELK1 ELK1 LOC105548744 LOC105548744 PPP4R4 PPP4R4 ENSMLEP00000009377 ENSMLEP00000009377 LOC105548749 LOC105548749 IRAK1 IRAK1 USP14 USP14 PELI2 PELI2 TAB3 TAB3 UBA52 UBA52 MAPK15 MAPK15 CREB5 CREB5 MAPKAPK3 MAPKAPK3 MAP3K7 MAP3K7 TAB2 TAB2 ALPK1 ALPK1 NLRP12 NLRP12 APP APP VWC2 VWC2 FOS FOS MAP2K4 MAP2K4 MEF2A MEF2A LRRC74A LRRC74A LRRC34 LRRC34 ENSMLEP00000034242 ENSMLEP00000034242 FNBP4 FNBP4 TONSL TONSL RELA RELA NLRC5 NLRC5 TP53 TP53 TRAF2 TRAF2 ENSMLEP00000037519 ENSMLEP00000037519 MAP3K8 MAP3K8 RPS6KA1 RPS6KA1 MAPK14 MAPK14 PPP2R1B PPP2R1B DUSP4 DUSP4 RPS6KA5 RPS6KA5 CUL1 CUL1 LOC105538326 LOC105538326 LRRC71 LRRC71 NFKBIB NFKBIB VRK3 VRK3 ENSMLEP00000026884 ENSMLEP00000026884 NFKBIA NFKBIA BTRC BTRC HMGB1 HMGB1 NLRP13 NLRP13 NKIRAS1 NKIRAS1 NOD2 NOD2 ENSMLEP00000024805 ENSMLEP00000024805 ENSMLEP00000024603 ENSMLEP00000024603 NLRP9 NLRP9 IRAK2 IRAK2 RIPK2 RIPK2 TAB1 TAB1 ENSMLEP00000024034 ENSMLEP00000024034 MAPK1 MAPK1 CHUK CHUK MAPK11 MAPK11 LOC105539754 LOC105539754 RELCH RELCH S100A12 S100A12 ATF2 ATF2 MAP3K20 MAP3K20 PPP2R5D PPP2R5D MEF2C MEF2C MAP3K1 MAP3K1 FBXW11 FBXW11 NOD1 NOD1 PPP2CB PPP2CB TNIP2 TNIP2 MAPK3 MAPK3 ATF7 ATF7 DUSP3 DUSP3 MAP2K1 MAP2K1 KHNYN KHNYN RPS6KA3 RPS6KA3 LOC105545975 LOC105545975 CREB1 CREB1 ENSMLEP00000018394 ENSMLEP00000018394 TMEM189 TMEM189 IKBKB IKBKB LOC105548751 LOC105548751 ENSMLEP00000016609 ENSMLEP00000016609 LRRC31 LRRC31 CREM CREM MAP2K7 MAP2K7 CASP8 CASP8 FOSL2 FOSL2 MAPK8 MAPK8 MYD88 MYD88 ENSMLEP00000015464 ENSMLEP00000015464 PPP2CA PPP2CA MAP2K6 MAP2K6 NLRX1 NLRX1 IRAK4 IRAK4 N4BP1 N4BP1 S100B S100B LOC105532112 LOC105532112
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP4R1Protein phosphatase 4 regulatory subunit 1. (919 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
NLRP6NLR family pyrin domain containing 6. (1044 aa)
ENSMLEP00000011388Ubiquitin-like domain-containing protein. (120 aa)
ATF1Activating transcription factor 1. (270 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (353 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
TLR10Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa)
RPS27AUbiquitin-like domain-containing protein. (138 aa)
ENSMLEP00000001074Uncharacterized protein. (172 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
UBE2NLUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (207 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
RPS6KA2Ribosomal protein S6 kinase. (728 aa)
LOC105541098Ubiquitin-like domain-containing protein. (156 aa)
ENSMLEP00000005424UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
MAPKAPK2MAPK activated protein kinase 2. (362 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
TIFATRAF interacting protein with forkhead associated domain. (185 aa)
ENSMLEP00000006240Ubiquitin-like domain-containing protein. (127 aa)
MAPK10Mitogen-activated protein kinase. (477 aa)
LRRC14Leucine rich repeat containing 14. (493 aa)
ECSITECSIT signalling integrator. (394 aa)
MAPK9Mitogen-activated protein kinase. (395 aa)
LOC105540679UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
LOC105536598Ubiquitin-like domain-containing protein. (156 aa)
ENSMLEP00000008311Uncharacterized protein; Belongs to the SKP1 family. (142 aa)
ELK1ETS transcription factor ELK1. (428 aa)
LOC105548744Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (843 aa)
ENSMLEP00000009377Zinc_ribbon_2 domain-containing protein. (100 aa)
LOC105548749Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (610 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (491 aa)
PELI2Pellino E3 ubiquitin protein ligase family member 2. (394 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
MAPK15Mitogen-activated protein kinase. (522 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
ALPK1Alpha kinase 1. (1244 aa)
NLRP12NLR family pyrin domain containing 12. (1031 aa)
APPAmyloid beta precursor protein. (772 aa)
VWC2Von Willebrand factor C domain containing 2. (212 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (373 aa)
MEF2AMyocyte enhancer factor 2A. (513 aa)
LRRC74ALeucine rich repeat containing 74A. (488 aa)
LRRC34Leucine rich repeat containing 34. (421 aa)
ENSMLEP00000034242Uncharacterized protein. (173 aa)
FNBP4Formin binding protein 4. (1017 aa)
TONSLTonsoku like, DNA repair protein. (1350 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
NLRC5NLR family CARD domain containing 5. (1866 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
ENSMLEP00000037519Uncharacterized protein. (87 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (637 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
RPS6KA5Ribosomal protein S6 kinase. (801 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
LOC105538326WRNPLPNID domain-containing protein. (953 aa)
LRRC71Leucine rich repeat containing 71. (559 aa)
NFKBIBNFKB inhibitor beta. (286 aa)
VRK3VRK serine/threonine kinase 3. (418 aa)
ENSMLEP00000026884Uncharacterized protein. (211 aa)
NFKBIAANK_REP_REGION domain-containing protein. (305 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
HMGB1High mobility group box 1. (215 aa)
NLRP13NLR family pyrin domain containing 13. (937 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1012 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
ENSMLEP00000024603UBIQUITIN_CONJUGAT_2 domain-containing protein. (102 aa)
NLRP9NLR family pyrin domain containing 9. (873 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (625 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
ENSMLEP00000024034UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MAPK11Mitogen-activated protein kinase. (224 aa)
LOC105539754CCHC NOA-type domain-containing protein. (361 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1195 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (90 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1347 aa)
FBXW11F-box and WD repeat domain containing 11. (546 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (961 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
TNIP2TNFAIP3 interacting protein 2. (322 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (494 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (171 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
KHNYNKH and NYN domain containing. (678 aa)
RPS6KA3Ribosomal protein S6 kinase. (742 aa)
LOC105545975Uncharacterized protein. (448 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ENSMLEP00000018394UBIQUITIN_CONJUGAT_2 domain-containing protein. (129 aa)
TMEM189Transmembrane protein 189. (237 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (706 aa)
LOC105548751Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
ENSMLEP00000016609Uncharacterized protein. (174 aa)
LRRC31Leucine rich repeat containing 31. (496 aa)
CREMcAMP responsive element modulator. (312 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (442 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (479 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (292 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
ENSMLEP00000015464Uncharacterized protein. (189 aa)
PPP2CASerine/threonine-protein phosphatase. (275 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa)
NLRX1NLR family member X1. (972 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
N4BP1NEDD4 binding protein 1. (863 aa)
S100BS_100 domain-containing protein; Belongs to the S-100 family. (94 aa)
LOC105532112Uncharacterized protein. (188 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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