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FTH1 FTH1 CLCN2 CLCN2 ATOX1 ATOX1 CALM1 CALM1 TLR4 TLR4 PDLIM3 PDLIM3 SCN8A SCN8A VDAC2 VDAC2 CALM2 CALM2 CACNA1G CACNA1G TRPM6 TRPM6 ADCY1 ADCY1 ICAM2 ICAM2 CCKBR CCKBR MCU MCU KCNC2 KCNC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FTH1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (199 aa)
CLCN2Chloride voltage-gated channel 2. (898 aa)
ATOX1HMA domain-containing protein. (73 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
PDLIM3PDZ and LIM domain 3. (326 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1980 aa)
VDAC2Voltage dependent anion channel 2. (308 aa)
CALM2Calmodulin 2. (149 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2360 aa)
TRPM6Transient receptor potential cation channel subfamily M member 6. (2032 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
ICAM2Intercellular adhesion molecule 2. (275 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (447 aa)
MCUMitochondrial calcium uniporter. (318 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (638 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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