STRINGSTRING
NF1 NF1 SHC3 SHC3 PIK3R2 PIK3R2 BAD BAD BAX BAX ENSMLEP00000004236 ENSMLEP00000004236 PDGFRB PDGFRB TBCA TBCA EIF4E EIF4E MTOR MTOR BCL2 BCL2 IGF1 IGF1 EGF EGF MET MET ERAS ERAS FGFR2 FGFR2 RPS6KB1 RPS6KB1 KRAS KRAS PDGFD PDGFD RPS6KB2 RPS6KB2 PDGFRA PDGFRA RAF1 RAF1 ENSMLEP00000012301 ENSMLEP00000012301 STAT3 STAT3 FGFR3 FGFR3 TPTE2 TPTE2 JAK2 JAK2 SHC4 SHC4 MAP2K2 MAP2K2 ERBB3 ERBB3 TGFA TGFA GAB1 GAB1 ERBB2 ERBB2 GRB2 GRB2 BCL2L1 BCL2L1 CEP152 CEP152 FGF2 FGF2 PIK3CA PIK3CA IL6 IL6 MAP2K1 MAP2K1 NRG1 NRG1 PRKCA PRKCA MAPK3 MAPK3 ENSMLEP00000021430 ENSMLEP00000021430 SOS1 SOS1 EIF4EBP1 EIF4EBP1 GAS6 GAS6 AKT2 AKT2 SOS2 SOS2 FOXO3 FOXO3 HGF HGF MAPK1 MAPK1 BCL2L11 BCL2L11 PLCG2 PLCG2 EGFR EGFR IGF1R IGF1R PRKCB PRKCB GSK3B GSK3B PRKCG PRKCG ENSMLEP00000024805 ENSMLEP00000024805 EIF4E2 EIF4E2 AXL AXL PTEN PTEN ARAF ARAF PIK3CD PIK3CD EIF4E1B EIF4E1B ENSMLEP00000027485 ENSMLEP00000027485 PDGFC PDGFC AKT1 AKT1 PIK3CB PIK3CB JAK1 JAK1 PLCG1 PLCG1 VEGFA VEGFA CSDE1 CSDE1 KDR KDR LOC105549202 LOC105549202 PDGFA PDGFA NRAS NRAS PPP1R14B PPP1R14B PDGFB PDGFB PIK3R3 PIK3R3 ENSMLEP00000031736 ENSMLEP00000031736 RPS6 RPS6 PIK3R1 PIK3R1 NRG2 NRG2 BRAF BRAF ENSMLEP00000035176 ENSMLEP00000035176 SRC SRC SHC1 SHC1 HRAS HRAS SHC2 SHC2 AKT3 AKT3 ENSMLEP00000037200 ENSMLEP00000037200 IL6R IL6R ENSMLEP00000040499 ENSMLEP00000040499
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NF1Neurofibromin 1. (2839 aa)
SHC3SHC adaptor protein 3. (444 aa)
PIK3R2Uncharacterized protein. (587 aa)
BADBCL2 associated agonist of cell death. (167 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
ENSMLEP00000004236SRCR domain-containing protein; Belongs to the eukaryotic initiation factor 4E family. (184 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (131 aa)
EIF4EEukaryotic translation initiation factor 4E. (247 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
IGF1Insulin like growth factor 1. (159 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1152 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1403 aa)
ERASES cell expressed Ras. (233 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PDGFDPlatelet derived growth factor D. (353 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
ENSMLEP00000012301Protein kinase domain-containing protein. (294 aa)
STAT3Signal transducer and activator of transcription. (693 aa)
FGFR3Fibroblast growth factor receptor. (771 aa)
TPTE2Uncharacterized protein. (550 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
SHC4SHC adaptor protein 4. (630 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (389 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1350 aa)
TGFATransforming growth factor alpha. (166 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
BCL2L1BCL2 like 1. (233 aa)
CEP152Centrosomal protein 152. (1709 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IL6Interleukin 6. (226 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NRG1Neuregulin 1. (713 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
ENSMLEP0000002143040S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (210 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1299 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (73 aa)
GAS6Growth arrest specific 6. (640 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1317 aa)
FOXO3Forkhead box O3. (670 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1221 aa)
EGFRReceptor protein-tyrosine kinase. (1188 aa)
IGF1RTyrosine-protein kinase receptor. (1281 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
PRKCGProtein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (558 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (249 aa)
AXLAXL receptor tyrosine kinase. (874 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (604 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (246 aa)
ENSMLEP00000027485PID domain-containing protein. (488 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1276 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (210 aa)
CSDE1Cold shock domain containing E1. (844 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
LOC10554920240S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (244 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (287 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PPP1R14BUncharacterized protein. (127 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
ENSMLEP0000003173640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (222 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (218 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
NRG2Neuregulin 2. (605 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
ENSMLEP00000035176Uncharacterized protein. (77 aa)
SRCTyrosine-protein kinase. (542 aa)
SHC1SHC adaptor protein 1. (584 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SHC2Uncharacterized protein. (483 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSMLEP00000037200Uncharacterized protein. (71 aa)
IL6RInterleukin 6 receptor. (468 aa)
ENSMLEP00000040499Uncharacterized protein. (147 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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