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LOC105553918 LOC105553918 PPP1R14B PPP1R14B GSTM5 GSTM5 LOC105553485 LOC105553485 PIK3R2 PIK3R2 GSTP1 GSTP1 BAD BAD BAX BAX BCL2 BCL2 LOC105533249 LOC105533249 MSH2 MSH2 ENSMLEP00000006706 ENSMLEP00000006706 MGST1 MGST1 GSTA2 GSTA2 ENSMLEP00000007765 ENSMLEP00000007765 LOC105532451 LOC105532451 CASP3 CASP3 REV3L REV3L MLH1 MLH1 ERCC1 ERCC1 CDKN1A CDKN1A ENSMLEP00000011647 ENSMLEP00000011647 PDPK1 PDPK1 LOC105552669 LOC105552669 BRCA1 BRCA1 ENSMLEP00000015528 ENSMLEP00000015528 CASP8 CASP8 LOC105530428 LOC105530428 ERBB2 ERBB2 ATP7A ATP7A BCL2L1 BCL2L1 CDKN2A CDKN2A BAK1 BAK1 BID BID PIK3CA PIK3CA MSH6 MSH6 TOP2B TOP2B MAPK3 MAPK3 AKT2 AKT2 POLH POLH BIRC2 BIRC2 MAPK1 MAPK1 ATM ATM APAF1 APAF1 GSTT2B GSTT2B C7orf31 C7orf31 GSTA5 GSTA5 SLC31A1 SLC31A1 PIK3CD PIK3CD GSTA3 GSTA3 FASLG FASLG ABCC2 ABCC2 GSTM2 GSTM2 FADD FADD AKT1 AKT1 PIK3CB PIK3CB ENSMLEP00000029067 ENSMLEP00000029067 MGST3 MGST3 GSTO2 GSTO2 ENSMLEP00000040499 ENSMLEP00000040499 MAP3K5 MAP3K5 LOC105537660 LOC105537660 LOC105552459 LOC105552459 ENSMLEP00000039277 ENSMLEP00000039277 XPA XPA GSTA1 GSTA1 GSTO1 GSTO1 TP53 TP53 AKT3 AKT3 GSTA4 GSTA4 MDM2 MDM2 CASP9 CASP9 MSH3 MSH3 BIRC3 BIRC3 GSTM3 GSTM3 ATP7B ATP7B PIK3R1 PIK3R1 XIAP XIAP TOP2A TOP2A PMAIP1 PMAIP1 MGST2 MGST2 FAS FAS PIK3R3 PIK3R3
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
LOC105553918Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PPP1R14BUncharacterized protein. (127 aa)
GSTM5Glutathione S-transferase. (198 aa)
LOC105553485Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PIK3R2Uncharacterized protein. (587 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
BADBCL2 associated agonist of cell death. (167 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
LOC105533249Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
MSH2MutS homolog 2; Component of the post-replicative DNA mismatch repair system (MMR). (845 aa)
ENSMLEP00000006706Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (96 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
GSTA2Glutathione S-transferase alpha 2; Belongs to the GST superfamily. (222 aa)
ENSMLEP00000007765Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC105532451Glutathione S-transferase. (190 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3127 aa)
MLH1MutL homolog 1. (756 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (323 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ENSMLEP00000011647GST N-terminal domain-containing protein. (67 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (529 aa)
LOC105552669Uncharacterized protein; Belongs to the peptidase C14A family. (215 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
ENSMLEP00000015528Uncharacterized protein. (184 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (479 aa)
LOC105530428Uncharacterized protein. (240 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
BCL2L1BCL2 like 1. (233 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
BIDBH3 interacting domain death agonist. (244 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1363 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1616 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
POLHDNA polymerase eta. (712 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (2965 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
GSTT2BUncharacterized protein; Belongs to the GST superfamily. (244 aa)
C7orf31Chromosome 7 open reading frame 31. (590 aa)
GSTA5Glutathione S-transferase alpha 5. (222 aa)
SLC31A1Solute carrier family 31 member 1. (191 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GSTA3Glutathione S-transferase alpha 3. (222 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
ABCC2ATP binding cassette subfamily C member 2. (1544 aa)
GSTM2Glutathione S-transferase. (221 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ENSMLEP00000029067Uncharacterized protein. (101 aa)
MGST3Uncharacterized protein. (154 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
ENSMLEP00000040499Uncharacterized protein. (147 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1306 aa)
LOC105537660Uncharacterized protein. (140 aa)
LOC105552459Uncharacterized protein. (163 aa)
ENSMLEP00000039277annotation not available (67 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
GSTA1Glutathione S-transferase alpha 1. (222 aa)
GSTO1Glutathione S-transferase omega 1. (241 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GSTA4Glutathione S-transferase alpha 4. (222 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (400 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1125 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
GSTM3Glutathione S-transferase. (210 aa)
ATP7BATPase copper transporting beta. (1470 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
XIAPX-linked inhibitor of apoptosis. (484 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
PMAIP1Uncharacterized protein. (133 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
FASFas cell surface death receptor. (331 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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