STRINGSTRING
MAP2K1 MAP2K1 ACTL8 ACTL8 RAC1 RAC1 ENSMLEP00000001003 ENSMLEP00000001003 ENSMLEP00000001022 ENSMLEP00000001022 FGF1 FGF1 PIK3R2 PIK3R2 RALGDS RALGDS ACTL7B ACTL7B ENSMLEP00000002165 ENSMLEP00000002165 RALB RALB NGFR NGFR PFN4 PFN4 ACTRT2 ACTRT2 ADCY4 ADCY4 ARAP3 ARAP3 PLCE1 PLCE1 ENSMLEP00000003362 ENSMLEP00000003362 ADCY9 ADCY9 EFNA3 EFNA3 ADCY7 ADCY7 LOC105540811 LOC105540811 CALML3 CALML3 GNAS GNAS PDGFRB PDGFRB CRK CRK ENSMLEP00000004779 ENSMLEP00000004779 RAPGEF6 RAPGEF6 RHOC RHOC ADCY8 ADCY8 APBB1IP APBB1IP PFN3 PFN3 PFN2 PFN2 ACTRT1 ACTRT1 RRAS RRAS IGF1 IGF1 EFNA5 EFNA5 GNAI2 GNAI2 LPAR4 LPAR4 EGF EGF P2RY1 P2RY1 MET MET ACTL7A ACTL7A FGF23 FGF23 ERAS ERAS KITLG KITLG SIPA1L3 SIPA1L3 FGFR2 FGFR2 GPR55 GPR55 PLCB1 PLCB1 AFDN AFDN EVL EVL FGFR4 FGFR4 LOC105530991 LOC105530991 FGF20 FGF20 KRAS KRAS PDGFD PDGFD KRIT1 KRIT1 RAP1A RAP1A CTNNB1 CTNNB1 THBS1 THBS1 FGF3 FGF3 ITGA2B ITGA2B AKT2 AKT2 ANGPT4 ANGPT4 ENSMLEP00000021422 ENSMLEP00000021422 RAPGEF1 RAPGEF1 MAPK3 MAPK3 PRKCA PRKCA MRAS MRAS CALML4 CALML4 DOCK4 DOCK4 FLT1 FLT1 LOC105540399 LOC105540399 F2R F2R RASGRP3 RASGRP3 PIK3CA PIK3CA CRKL CRKL CALM2 CALM2 MAGI2 MAGI2 ENSMLEP00000018922 ENSMLEP00000018922 TIAM1 TIAM1 ENSMLEP00000018677 ENSMLEP00000018677 RAC2 RAC2 FGF16 FGF16 ENSMLEP00000018399 ENSMLEP00000018399 FGF5 FGF5 PVALEF PVALEF FGF2 FGF2 LOC105530438 LOC105530438 INSR INSR EPHA2 EPHA2 PRKD3 PRKD3 RAP1GAP RAP1GAP ADCY2 ADCY2 PRKCZ PRKCZ INS INS PARD6A PARD6A MAGI3 MAGI3 RAPGEF2 RAPGEF2 ITGAM ITGAM MAP2K2 MAP2K2 ITGB3 ITGB3 LOC105549769 LOC105549769 LOC105552366 LOC105552366 MAP2K6 MAP2K6 ENSMLEP00000014023 ENSMLEP00000014023 FARP2 FARP2 EFNA4 EFNA4 FGFR3 FGFR3 MAP2K3 MAP2K3 ENSMLEP00000012301 ENSMLEP00000012301 ENSMLEP00000012170 ENSMLEP00000012170 ANGPT2 ANGPT2 RAP1GAP2 RAP1GAP2 LOC105553882 LOC105553882 FGF18 FGF18 RAF1 RAF1 FGFR1 FGFR1 SIPA1L1 SIPA1L1 ENSMLEP00000011086 ENSMLEP00000011086 PDGFRA PDGFRA CALM1 CALM1 VAV1 VAV1 FGF9 FGF9 RALA RALA ADAM15 ADAM15 RASSF5 RASSF5 VAV2 VAV2 SKAP1 SKAP1 SIPA1L2 SIPA1L2 SIPA1 SIPA1 FGF10 FGF10 GNAQ GNAQ PGF PGF PLCB4 PLCB4 ADORA2A ADORA2A VAV3 VAV3 FLT4 FLT4 MAPK13 MAPK13 KIT KIT TRAC TRAC VEGFB VEGFB PRKCI PRKCI PIK3R3 PIK3R3 PDGFB PDGFB ENAH ENAH NRAS NRAS PDGFA PDGFA RGS14 RGS14 KDR KDR MAGI1 MAGI1 ITGAL ITGAL ANGPT1 ANGPT1 HGF HGF PARD6B PARD6B PLCB2 PLCB2 MAPK11 MAPK11 MAPK1 MAPK1 RGS12 RGS12 ADCY1 ADCY1 FGF6 FGF6 LOC105548340 LOC105548340 EGFR EGFR IGF1R IGF1R PRKCB PRKCB CSF1 CSF1 PRKCG PRKCG ENSMLEP00000024790 ENSMLEP00000024790 ENSMLEP00000024805 ENSMLEP00000024805 LCP2 LCP2 ADCY5 ADCY5 LOC105533469 LOC105533469 FYB1 FYB1 GALK2 GALK2 RPS6KL1 RPS6KL1 ITGB2 ITGB2 PIK3CD PIK3CD ENSMLEP00000026117 ENSMLEP00000026117 GNAI3 GNAI3 ADCY3 ADCY3 ENSMLEP00000027131 ENSMLEP00000027131 MAPK12 MAPK12 PDGFC PDGFC RAP1B RAP1B AKT1 AKT1 GRIN2A GRIN2A PIK3CB PIK3CB LOC105540582 LOC105540582 RHOA RHOA LOC105553738 LOC105553738 ADORA2B ADORA2B PRKD1 PRKD1 PLCG1 PLCG1 ITGB1 ITGB1 GNAO1 GNAO1 VEGFA VEGFA CSDE1 CSDE1 TEK TEK FGF8 FGF8 TLN2 TLN2 CSF1R CSF1R ACTB ACTB LPAR2 LPAR2 FGF21 FGF21 CALML6 CALML6 DRD2 DRD2 VEGFC VEGFC RAC3 RAC3 ENSMLEP00000039500 ENSMLEP00000039500 LPAR3 LPAR3 LPAR1 LPAR1 VEGFD VEGFD PLCB3 PLCB3 FGF17 FGF17 RGL4 RGL4 ENSMLEP00000038520 ENSMLEP00000038520 MAPK14 MAPK14 ID1 ID1 RAPGEF4 RAPGEF4 ADCY6 ADCY6 NGF NGF AKT3 AKT3 ACTG1 ACTG1 CTNND1 CTNND1 FGF19 FGF19 PFN1 PFN1 RASGRP2 RASGRP2 HRAS HRAS RAPGEF5 RAPGEF5 CDC42 CDC42 LAT LAT SRC SRC CDH1 CDH1 RAPGEF3 RAPGEF3 BRAF BRAF VASP VASP LOC105542528 LOC105542528 TLN1 TLN1 PRKD2 PRKD2 GNAI1 GNAI1 EFNA1 EFNA1 PIK3R1 PIK3R1 FGF7 FGF7 BCAR1 BCAR1 CALM3 CALM3 ENSMLEP00000022318 ENSMLEP00000022318
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
RAC1Uncharacterized protein. (280 aa)
ENSMLEP00000001003CaM_bdg_C0 domain-containing protein. (124 aa)
ENSMLEP00000001022Uncharacterized protein. (189 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PIK3R2Uncharacterized protein. (587 aa)
RALGDSUncharacterized protein. (911 aa)
ACTL7BActin like 7B; Belongs to the actin family. (415 aa)
ENSMLEP00000002165Uncharacterized protein; Belongs to the calmodulin family. (95 aa)
RALBRAS like proto-oncogene B. (212 aa)
NGFRNerve growth factor receptor. (423 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (377 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ARAP3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3. (1540 aa)
PLCE1Phosphoinositide phospholipase C. (2303 aa)
ENSMLEP00000003362Uncharacterized protein. (185 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
EFNA3Ephrin A3; Belongs to the ephrin family. (238 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
LOC105540811Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
GNASGNAS complex locus. (998 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
CRKCRK proto-oncogene, adaptor protein. (245 aa)
ENSMLEP00000004779Uncharacterized protein. (139 aa)
RAPGEF6Uncharacterized protein. (1609 aa)
RHOCRas homolog family member C. (193 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
APBB1IPAmyloid beta precursor protein binding family B member 1 interacting protein. (547 aa)
PFN3Profilin; Belongs to the profilin family. (137 aa)
PFN2Profilin; Belongs to the profilin family. (91 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (375 aa)
RRASRAS related. (218 aa)
IGF1Insulin like growth factor 1. (159 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (219 aa)
GNAI2G protein subunit alpha i2. (352 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1152 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1403 aa)
ACTL7AActin like 7A; Belongs to the actin family. (435 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
ERASES cell expressed Ras. (233 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
SIPA1L3Signal induced proliferation associated 1 like 3. (1740 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
GPR55G protein-coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (319 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
AFDNAfadin, adherens junction formation factor. (1799 aa)
EVLEnah/Vasp-like; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (418 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
LOC105530991Uncharacterized protein. (185 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PDGFDPlatelet derived growth factor D. (353 aa)
KRIT1Uncharacterized protein. (736 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
CTNNB1Catenin beta 1. (781 aa)
THBS1Thrombospondin 1. (1170 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ANGPT4Angiopoietin 4. (503 aa)
ENSMLEP00000021422PB1 domain-containing protein. (130 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1100 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
CALML4Calmodulin like 4. (193 aa)
DOCK4Dedicator of cytokinesis 4; Belongs to the DOCK family. (2011 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1316 aa)
LOC105540399Uncharacterized protein; Belongs to the actin family. (362 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
RASGRP3RAS guanyl releasing protein 3. (734 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
CALM2Calmodulin 2. (149 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1125 aa)
ENSMLEP00000018922ANF_receptor domain-containing protein. (356 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
ENSMLEP00000018677Uncharacterized protein. (185 aa)
RAC2Rac family small GTPase 2. (192 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ENSMLEP00000018399Uncharacterized protein. (153 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
LOC105530438Ras-GEF domain-containing protein. (560 aa)
INSRTyrosine-protein kinase receptor. (1301 aa)
EPHA2EPH receptor A2. (976 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa)
RAP1GAPRAP1 GTPase activating protein. (712 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (901 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
MAGI3Membrane associated guanylate kinase, WW and PDZ domain containing 3. (1441 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1632 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (389 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
LOC105549769Uncharacterized protein. (182 aa)
LOC105552366Ras-GEF domain-containing protein. (600 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa)
ENSMLEP00000014023Ras-GEF domain-containing protein. (387 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1055 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (206 aa)
FGFR3Fibroblast growth factor receptor. (771 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
ENSMLEP00000012301Protein kinase domain-containing protein. (294 aa)
ENSMLEP00000012170Ig-like domain-containing protein. (147 aa)
ANGPT2Angiopoietin 2. (496 aa)
RAP1GAP2RAP1 GTPase activating protein 2. (754 aa)
LOC105553882Uncharacterized protein. (356 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
FGFR1Fibroblast growth factor receptor. (853 aa)
SIPA1L1Signal induced proliferation associated 1 like 1. (1804 aa)
ENSMLEP00000011086Ig-like domain-containing protein. (174 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
VAV1Vav guanine nucleotide exchange factor 1. (766 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
RALARAS like proto-oncogene A. (206 aa)
ADAM15ADAM metallopeptidase domain 15. (864 aa)
RASSF5Ras association domain family member 5. (418 aa)
VAV2Vav guanine nucleotide exchange factor 2. (787 aa)
SKAP1Src kinase associated phosphoprotein 1. (356 aa)
SIPA1L2Signal induced proliferation associated 1 like 2. (1722 aa)
SIPA1Signal-induced proliferation-associated 1. (851 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GNAQG protein subunit alpha q. (313 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1169 aa)
MAPK13Mitogen-activated protein kinase. (397 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
TRACT cell receptor alpha constant. (110 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (168 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (583 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ENAHENAH actin regulator. (790 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (287 aa)
RGS14Regulator of G protein signaling 14. (565 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
MAGI1Membrane associated guanylate kinase, WW and PDZ domain containing 1. (1459 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1148 aa)
ANGPT1Angiopoietin 1. (498 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
MAPK11Mitogen-activated protein kinase. (224 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
RGS12Regulator of G protein signaling 12. (1439 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC105548340Uncharacterized protein. (246 aa)
EGFRReceptor protein-tyrosine kinase. (1188 aa)
IGF1RTyrosine-protein kinase receptor. (1281 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
PRKCGProtein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (558 aa)
ENSMLEP00000024790Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (294 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa)
LOC105533469Ras-GEF domain-containing protein. (540 aa)
FYB1FYN binding protein 1. (839 aa)
GALK2Galactokinase 2. (458 aa)
RPS6KL1Ribosomal protein S6 kinase like 1. (549 aa)
ITGB2Integrin beta. (769 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ENSMLEP00000026117annotation not available (172 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
ENSMLEP00000027131Uncharacterized protein. (130 aa)
MAPK12Mitogen-activated protein kinase. (292 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
RAP1BUncharacterized protein. (184 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1422 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
LOC105540582Ras-GEF domain-containing protein. (407 aa)
RHOARas homolog family member A. (193 aa)
LOC105553738Uncharacterized protein. (160 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (331 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1276 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (748 aa)
GNAO1G protein subunit alpha o1. (354 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (210 aa)
CSDE1Cold shock domain containing E1. (844 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
TLN2Talin 2. (2544 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
ACTBActin beta. (375 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
FGF21Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. (174 aa)
CALML6Calmodulin like 6. (181 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (402 aa)
RAC3Rac family small GTPase 3. (212 aa)
ENSMLEP00000039500Profilin; Belongs to the profilin family. (146 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (353 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
RGL4Ras-GEF domain-containing protein. (591 aa)
ENSMLEP00000038520Uncharacterized protein; Belongs to the calmodulin family. (91 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (989 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (123 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ACTG1Actin gamma 1. (376 aa)
CTNND1Catenin delta 1. (968 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (308 aa)
PFN1Profilin; Belongs to the profilin family. (104 aa)
RASGRP2RAS guanyl releasing protein 2. (609 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (730 aa)
CDC42Uncharacterized protein. (191 aa)
LATLinker for activation of T cells. (235 aa)
SRCTyrosine-protein kinase. (542 aa)
CDH1Cadherin 1. (628 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (925 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
VASPVasodilator stimulated phosphoprotein. (432 aa)
LOC105542528Uncharacterized protein. (173 aa)
TLN1Talin 1. (2547 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (888 aa)
GNAI1G protein subunit alpha i1. (314 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
CALM3Calmodulin 3. (149 aa)
ENSMLEP00000022318PDZ domain-containing protein. (197 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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