STRINGSTRING
CYBB CYBB CAMK2D CAMK2D EIF4EBP1 EIF4EBP1 ENSMLEP00000000865 ENSMLEP00000000865 CREBBP CREBBP LDHA LDHA ENSMLEP00000001692 ENSMLEP00000001692 PIK3R2 PIK3R2 HK2 HK2 PFKM PFKM GAPDH GAPDH SLC2A1 SLC2A1 CUL2 CUL2 ENSMLEP00000004236 ENSMLEP00000004236 EDN1 EDN1 TBCA TBCA EIF4E EIF4E HKDC1 HKDC1 MTOR MTOR BCL2 BCL2 IGF1 IGF1 ZAN ZAN EGF EGF LOC105544892 LOC105544892 PDHA2 PDHA2 RPS6KB1 RPS6KB1 PGK2 PGK2 CAMK2B CAMK2B LDHC LDHC CAMK2G CAMK2G ALDOB ALDOB ALDOC ALDOC LOC105546272 LOC105546272 RPS6KB2 RPS6KB2 LOC105540063 LOC105540063 IFNGR1 IFNGR1 LTBR LTBR CDKN1B CDKN1B ENSMLEP00000011026 ENSMLEP00000011026 ALDOA ALDOA CDKN1A CDKN1A ANGPT2 ANGPT2 LOC105537007 LOC105537007 HK1 HK1 PFKL PFKL EPO EPO ENO4 ENO4 ENSMLEP00000012473 ENSMLEP00000012473 STAT3 STAT3 NFKB1 NFKB1 EGLN1 EGLN1 TLR4 TLR4 LOC105536376 LOC105536376 NOS3 NOS3 ENSMLEP00000014688 ENSMLEP00000014688 ENO1 ENO1 MAP2K2 MAP2K2 ENSMLEP00000015363 ENSMLEP00000015363 PDK1 PDK1 HK3 HK3 EGLN3 EGLN3 ENSMLEP00000016003 ENSMLEP00000016003 INS INS PFKP PFKP HIF1A HIF1A ERBB2 ERBB2 TFRC TFRC ENSMLEP00000017232 ENSMLEP00000017232 INSR INSR HMOX1 HMOX1 PDHA1 PDHA1 LOC105555267 LOC105555267 PIK3CA PIK3CA IL6 IL6 MAP2K1 MAP2K1 NPPA NPPA ENSMLEP00000020080 ENSMLEP00000020080 ENO3 ENO3 MKNK2 MKNK2 FLT1 FLT1 PRKCA PRKCA MAPK3 MAPK3 LOC105547422 LOC105547422 ENSMLEP00000021430 ENSMLEP00000021430 TIMP1 TIMP1 ANGPT4 ANGPT4 AKT2 AKT2 IFNG IFNG TF TF ENSMLEP00000022706 ENSMLEP00000022706 ANGPT1 ANGPT1 ENO2 ENO2 LOC105536897 LOC105536897 LOC105546877 LOC105546877 MAPK1 MAPK1 PLCG2 PLCG2 EGFR EGFR IGF1R IGF1R PRKCB PRKCB PRKCG PRKCG ENSMLEP00000024805 ENSMLEP00000024805 EIF4E2 EIF4E2 PIK3CD PIK3CD EIF4E1B EIF4E1B LOC105553274 LOC105553274 ENSMLEP00000026664 ENSMLEP00000026664 EGLN2 EGLN2 IFNGR2 IFNGR2 LTF LTF NOS2 NOS2 AKT1 AKT1 LOC105552202 LOC105552202 PIK3CB PIK3CB PLCG1 PLCG1 VEGFA VEGFA TEK TEK LOC105549202 LOC105549202 ARSI ARSI SERPINE1 SERPINE1 PIK3R3 PIK3R3 LOC105553530 LOC105553530 EP300 EP300 ENSMLEP00000031736 ENSMLEP00000031736 CAMK2A CAMK2A RPS6 RPS6 ENSMLEP00000032845 ENSMLEP00000032845 ELOC ELOC PIK3R1 PIK3R1 PFKFB3 PFKFB3 ENSMLEP00000034359 ENSMLEP00000034359 LOC105534235 LOC105534235 LDHAL6A LDHAL6A RELA RELA LOC105547911 LOC105547911 PGK1 PGK1 AKT3 AKT3 PDHB PDHB ENSMLEP00000037200 ENSMLEP00000037200 ENSMLEP00000037913 ENSMLEP00000037913 LOC105545047 LOC105545047 MKNK1 MKNK1 ENSMLEP00000038844 ENSMLEP00000038844 IL6R IL6R ENSMLEP00000039136 ENSMLEP00000039136 ARNT ARNT RBX1 RBX1 ENSMLEP00000040551 ENSMLEP00000040551
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CYBBCytochrome b-245 beta chain. (486 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (441 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (73 aa)
ENSMLEP00000000865L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (313 aa)
CREBBPCREB binding protein. (2423 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (289 aa)
ENSMLEP00000001692Uncharacterized protein; Belongs to the LDH/MDH superfamily. (392 aa)
PIK3R2Uncharacterized protein. (587 aa)
HK2Hexokinase 2. (901 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
CUL2Cullin 2; Belongs to the cullin family. (758 aa)
ENSMLEP00000004236SRCR domain-containing protein; Belongs to the eukaryotic initiation factor 4E family. (184 aa)
EDN1Endothelin 1. (211 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (131 aa)
EIF4EEukaryotic translation initiation factor 4E. (247 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
IGF1Insulin like growth factor 1. (159 aa)
ZANZonadhesin (gene/pseudogene). (2541 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1152 aa)
LOC105544892L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (388 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PGK2Phosphoglycerate kinase. (417 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (689 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (546 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (370 aa)
LOC105546272PFK domain-containing protein. (189 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
LOC105540063Phosphoglycerate kinase. (367 aa)
IFNGR1Interferon gamma receptor 1. (488 aa)
LTBRLymphotoxin beta receptor. (435 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
ENSMLEP00000011026Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (318 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (743 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ANGPT2Angiopoietin 2. (496 aa)
LOC105537007Ubiquitin-like domain-containing protein. (103 aa)
HK1Hexokinase 1. (921 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (779 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
ENO4Enolase 4. (627 aa)
ENSMLEP00000012473Uncharacterized protein; Belongs to the LDH/MDH superfamily. (339 aa)
STAT3Signal transducer and activator of transcription. (693 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
EGLN1Fe2OG dioxygenase domain-containing protein. (128 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
LOC105536376Phosphoglycerate kinase. (462 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1155 aa)
ENSMLEP00000014688Phosphoglycerate kinase. (349 aa)
ENO1Uncharacterized protein. (434 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (389 aa)
ENSMLEP00000015363Uncharacterized protein. (66 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
HK3Hexokinase 3. (923 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
ENSMLEP00000016003Uncharacterized protein. (92 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (775 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (758 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
TFRCTransferrin receptor. (679 aa)
ENSMLEP00000017232Phosphoglycerate kinase. (374 aa)
INSRTyrosine-protein kinase receptor. (1301 aa)
HMOX1Heme oxygenase 1. (311 aa)
PDHA1E1_dh domain-containing protein. (397 aa)
LOC105555267Uncharacterized protein. (433 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IL6Interleukin 6. (226 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NPPANatriuretic peptide A. (153 aa)
ENSMLEP00000020080Uncharacterized protein; Belongs to the LDH/MDH superfamily. (263 aa)
ENO3Enolase 3. (434 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (383 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1316 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
LOC105547422Uncharacterized protein; Belongs to the LDH/MDH superfamily. (294 aa)
ENSMLEP0000002143040S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (210 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
ANGPT4Angiopoietin 4. (503 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
TFTransferrin; Belongs to the transferrin family. (698 aa)
ENSMLEP00000022706Zf-rbx1 domain-containing protein. (93 aa)
ANGPT1Angiopoietin 1. (498 aa)
ENO2Enolase 2. (434 aa)
LOC105536897Uncharacterized protein. (368 aa)
LOC105546877Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (371 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1221 aa)
EGFRReceptor protein-tyrosine kinase. (1188 aa)
IGF1RTyrosine-protein kinase receptor. (1281 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
PRKCGProtein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (558 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (249 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (246 aa)
LOC105553274L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (323 aa)
ENSMLEP00000026664L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (354 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (405 aa)
IFNGR2Interferon gamma receptor 2. (408 aa)
LTFLactotransferrin; Belongs to the transferrin family. (710 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1147 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
LOC105552202E1_dh domain-containing protein. (359 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1276 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (210 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
LOC10554920240S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (244 aa)
ARSIArylsulfatase family member I. (568 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
LOC105553530Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (303 aa)
EP300E1A binding protein p300. (2411 aa)
ENSMLEP0000003173640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (222 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (218 aa)
ENSMLEP00000032845Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (320 aa)
ELOCElongin C; Belongs to the SKP1 family. (96 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (560 aa)
ENSMLEP00000034359Uncharacterized protein; Belongs to the LDH/MDH superfamily. (273 aa)
LOC105534235L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (310 aa)
LDHAL6AL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
LOC105547911Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
PGK1Phosphoglycerate kinase. (400 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
ENSMLEP00000037200Uncharacterized protein. (71 aa)
ENSMLEP00000037913Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (297 aa)
LOC105545047Uncharacterized protein; Belongs to the LDH/MDH superfamily. (289 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (465 aa)
ENSMLEP00000038844VHL domain-containing protein. (120 aa)
IL6RInterleukin 6 receptor. (468 aa)
ENSMLEP00000039136Gp_dh_N domain-containing protein. (305 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (734 aa)
RBX1RING-type domain-containing protein. (108 aa)
ENSMLEP00000040551VWFD domain-containing protein. (134 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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