STRINGSTRING
GADD45G GADD45G MAP2K2 MAP2K2 FBXO32 FBXO32 IL10 IL10 ENSMLEP00000015404 ENSMLEP00000015404 MAPK8 MAPK8 REM2 REM2 INS INS TSSK3 TSSK3 RASGEF1A RASGEF1A SMAD3 SMAD3 SGK1 SGK1 SETD7 SETD7 PLK4 PLK4 CCNB2 CCNB2 INSR INSR IKBKB IKBKB GRB2 GRB2 FOXJ3 FOXJ3 SUCO SUCO GADD45A GADD45A PIK3CA PIK3CA IL6 IL6 IL7R IL7R MAP2K1 MAP2K1 MYO9B MYO9B G6PC3 G6PC3 MAPK3 MAPK3 CCNG2 CCNG2 TGFBR1 TGFBR1 SOS1 SOS1 AKT2 AKT2 SOS2 SOS2 FOXO3 FOXO3 USP7 USP7 PLK1 PLK1 MAPK11 MAPK11 CHUK CHUK BNIP3 BNIP3 MAPK1 MAPK1 ATM ATM GADD45B GADD45B BCL2L11 BCL2L11 EGFR EGFR SKP2 SKP2 IGF1R IGF1R ENSMLEP00000024805 ENSMLEP00000024805 CAT CAT BCL6 BCL6 FOXJ2 FOXJ2 PTEN PTEN GRM1 GRM1 ARAF ARAF PIK3CD PIK3CD CDKN2B CDKN2B PMEPA1 PMEPA1 FASLG FASLG LOC105538880 LOC105538880 GABARAPL1 GABARAPL1 PRKAG2 PRKAG2 MAPK12 MAPK12 CNTD2 CNTD2 BCL6B BCL6B STK11 STK11 AKT1 AKT1 PIK3CB PIK3CB GABARAP GABARAP RBL2 RBL2 RNF6 RNF6 CSDE1 CSDE1 SLC35E3 SLC35E3 NRAS NRAS PIK3R3 PIK3R3 SGK2 SGK2 LOC105546715 LOC105546715 EP300 EP300 TGFB3 TGFB3 FOXO4 FOXO4 TGFBR2 TGFBR2 ENSMLEP00000036527 ENSMLEP00000036527 PCK2 PCK2 AKT3 AKT3 G6PC2 G6PC2 MAPK14 MAPK14 PCK1 PCK1 CCNB3 CCNB3 RNF111 RNF111 AGAP2 AGAP2 G6PC G6PC PIK3R2 PIK3R2 PRMT8 PRMT8 RAG1 RAG1 TSSK6 TSSK6 TGFB1 TGFB1 ENSMLEP00000003274 ENSMLEP00000003274 PRKAA2 PRKAA2 HOMER2 HOMER2 S1PR1 S1PR1 S1PR4 S1PR4 MYO9A MYO9A SIRT1 SIRT1 PRKAB1 PRKAB1 GABARAPL2 GABARAPL2 REM1 REM1 FOXG1 FOXG1 TGFB2 TGFB2 IGF1 IGF1 EGF EGF MAPK10 MAPK10 ENSMLEP00000006533 ENSMLEP00000006533 ERAS ERAS MAPK9 MAPK9 SMAD4 SMAD4 CDK3 CDK3 RAG2 RAG2 NLK NLK PRKAG3 PRKAG3 CDK2 CDK2 KRAS KRAS IRS4 IRS4 CCNB1 CCNB1 CDKN1B CDKN1B IRS1 IRS1 SLC2A4 SLC2A4 RAF1 RAF1 CDKN1A CDKN1A PDPK1 PDPK1 RASGEF1B RASGEF1B SNAPIN SNAPIN ENSMLEP00000012301 ENSMLEP00000012301 FBXO25 FBXO25 STAT3 STAT3 GRAP GRAP TPTE2 TPTE2 LDLRAD4 LDLRAD4 STK4 STK4 GEM GEM ATG12 ATG12 TNFSF10 TNFSF10 TMEM232 TMEM232 SOD2 SOD2 HOMER1 HOMER1 MAPK13 MAPK13 ENSMLEP00000033047 ENSMLEP00000033047 PRKAG1 PRKAG1 PLK3 PLK3 PRKAB2 PRKAB2 PIK3R1 PIK3R1 CCND2 CCND2 SGK3 SGK3 PRKAA1 PRKAA1 BRAF BRAF TSSK4 TSSK4 PRMT3 PRMT3 ENSMLEP00000035176 ENSMLEP00000035176 RRAD RRAD HRAS HRAS ENSMLEP00000036221 ENSMLEP00000036221 MDM2 MDM2 PRMT1 PRMT1 PLK2 PLK2 CREBBP CREBBP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (389 aa)
FBXO32F-box protein 32. (355 aa)
IL10Interleukin 10. (178 aa)
ENSMLEP00000015404Fork-head domain-containing protein. (531 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
TSSK3Testis specific serine kinase 3. (268 aa)
RASGEF1ARasGEF domain family member 1A. (489 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
SETD7Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa)
PLK4Polo like kinase 4. (971 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
INSRTyrosine-protein kinase receptor. (1301 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (706 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
FOXJ3Forkhead box J3. (631 aa)
SUCOSUN domain containing ossification factor. (1395 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IL6Interleukin 6. (226 aa)
IL7RInterleukin 7 receptor. (459 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1906 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (344 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1299 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1317 aa)
FOXO3Forkhead box O3. (670 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1116 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
MAPK11Mitogen-activated protein kinase. (224 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
BNIP3BCL2 interacting protein 3. (215 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (2965 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (176 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
EGFRReceptor protein-tyrosine kinase. (1188 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
IGF1RTyrosine-protein kinase receptor. (1281 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
BCL6BCL6 transcription repressor. (708 aa)
FOXJ2Forkhead box J2. (555 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
GRM1Glutamate metabotropic receptor 1. (961 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (604 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (157 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (259 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
LOC105538880Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
GABARAPL1GABA type A receptor associated protein like 1. (146 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (506 aa)
MAPK12Mitogen-activated protein kinase. (292 aa)
CNTD2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (198 aa)
BCL6BBCL6B transcription repressor. (475 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
RBL2RB transcriptional corepressor like 2. (1139 aa)
RNF6Ring finger protein 6. (701 aa)
CSDE1Cold shock domain containing E1. (844 aa)
SLC35E3Solute carrier family 35 member E3. (313 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa)
LOC105546715Uncharacterized protein. (319 aa)
EP300E1A binding protein p300. (2411 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FOXO4Forkhead box O4. (505 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (560 aa)
ENSMLEP00000036527Uncharacterized protein. (89 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (1365 aa)
RNF111Ring finger protein 111. (994 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (756 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
PIK3R2Uncharacterized protein. (587 aa)
PRMT8Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
TSSK6Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa)
TGFB1Transforming growth factor beta 1. (226 aa)
ENSMLEP00000003274Uncharacterized protein. (105 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
HOMER2Homer scaffold protein 2. (356 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
S1PR4Sphingosine-1-phosphate receptor 4. (384 aa)
MYO9AMyosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2535 aa)
SIRT1Sirtuin 1. (661 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
FOXG1Uncharacterized protein. (151 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IGF1Insulin like growth factor 1. (159 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1152 aa)
MAPK10Mitogen-activated protein kinase. (477 aa)
ENSMLEP00000006533Uncharacterized protein. (189 aa)
ERASES cell expressed Ras. (233 aa)
MAPK9Mitogen-activated protein kinase. (395 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
RAG2Recombination activating 2. (527 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
IRS4Insulin receptor substrate 4. (1245 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (433 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (529 aa)
RASGEF1BRasGEF domain family member 1B. (503 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
ENSMLEP00000012301Protein kinase domain-containing protein. (294 aa)
FBXO25F-box protein 25. (367 aa)
STAT3Signal transducer and activator of transcription. (693 aa)
GRAPGRB2 related adaptor protein. (217 aa)
TPTE2Uncharacterized protein. (550 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
STK4Serine/threonine kinase 4. (487 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (281 aa)
TMEM232Uncharacterized protein. (285 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (236 aa)
HOMER1Homer scaffold protein 1. (358 aa)
MAPK13Mitogen-activated protein kinase. (397 aa)
ENSMLEP00000033047Uncharacterized protein. (67 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (326 aa)
PLK3Serine/threonine-protein kinase PLK. (626 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
TSSK4Testis specific serine kinase 4. (338 aa)
PRMT3Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (531 aa)
ENSMLEP00000035176Uncharacterized protein. (77 aa)
RRADRRAD, Ras related glycolysis inhibitor and calcium channel regulator. (248 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ENSMLEP00000036221WH1 domain-containing protein. (262 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
CREBBPCREB binding protein. (2423 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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