STRINGSTRING
GAB2 GAB2 CSDE1 CSDE1 ENSMLEP00000029152 ENSMLEP00000029152 JMJD7 JMJD7 PLCG1 PLCG1 GNA12 GNA12 ENSMLEP00000028290 ENSMLEP00000028290 RHOA RHOA LOC105540582 LOC105540582 PIK3CB PIK3CB AKT1 AKT1 PDGFC PDGFC ENSMLEP00000027485 ENSMLEP00000027485 ADCY3 ADCY3 GRM8 GRM8 PLD2 PLD2 ENSMLEP00000026117 ENSMLEP00000026117 PIK3CD PIK3CD GRM1 GRM1 DGKE DGKE TSC1 TSC1 LOC105533469 LOC105533469 ADCY5 ADCY5 SPHK1 SPHK1 ENSMLEP00000024805 ENSMLEP00000024805 ENSMLEP00000024790 ENSMLEP00000024790 AGTR1 AGTR1 PLD1 PLD1 EGFR EGFR PLCG2 PLCG2 LOC105548340 LOC105548340 ADCY1 ADCY1 MAPK1 MAPK1 PLCB2 PLCB2 PLA2G4C PLA2G4C DGKI DGKI MS4A2 MS4A2 SOS2 SOS2 AKT2 AKT2 PIK3R6 PIK3R6 ENSMLEP00000021624 ENSMLEP00000021624 SOS1 SOS1 MAPK3 MAPK3 PRKCA PRKCA MRAS MRAS MAP2K1 MAP2K1 F2R F2R PIK3CA PIK3CA AGPAT3 AGPAT3 AGT AGT CYTH2 CYTH2 CYTH1 CYTH1 ENSMLEP00000018490 ENSMLEP00000018490 LOC105530438 LOC105530438 GRB2 GRB2 INSR INSR DNM1 DNM1 ADCY2 ADCY2 GAB1 GAB1 INS INS PIP5K1A PIP5K1A AGPAT4 AGPAT4 FYN FYN DGKK DGKK DNM2 DNM2 CXCL8 CXCL8 MAP2K2 MAP2K2 LOC105552366 LOC105552366 PIP5K1C PIP5K1C PLA2G4A PLA2G4A SHC4 SHC4 PTGFR PTGFR GAB4 GAB4 DGKG DGKG ENSMLEP00000014023 ENSMLEP00000014023 PTK2B PTK2B PIP5K1B PIP5K1B ENSMLEP00000012128 ENSMLEP00000012128 PIK3CG PIK3CG RAF1 RAF1 PDGFRA PDGFRA AVPR1A AVPR1A PLPP1 PLPP1 RALA RALA PTK6 PTK6 RHEB RHEB PLCB4 PLCB4 PIK3R5 PIK3R5 GRM3 GRM3 PLPP3 PLPP3 PDGFD PDGFD AGPAT5 AGPAT5 KRAS KRAS PLCB1 PLCB1 GPR55 GPR55 RUFY4 RUFY4 KITLG KITLG ERAS ERAS DGKZ DGKZ PTPN11 PTPN11 LPAR6 LPAR6 EGF EGF LPAR4 LPAR4 RRAS RRAS FCER1A FCER1A DGKB DGKB MTOR MTOR ADCY8 ADCY8 GRM2 GRM2 RHOC RHOC DGKQ DGKQ PDGFRB PDGFRB DGKA DGKA DGKH DGKH ARF6 ARF6 GNAS GNAS ADCY7 ADCY7 ADCY9 ADCY9 ENSMLEP00000003362 ENSMLEP00000003362 ADCY4 ADCY4 DNM3 DNM3 RALB RALB PLA2G4F PLA2G4F RALGDS RALGDS PLA2G4E PLA2G4E PIK3R2 PIK3R2 SHC3 SHC3 CEP152 CEP152 RGL4 RGL4 DGKD DGKD PLCB3 PLCB3 LPAR1 LPAR1 LPAR3 LPAR3 F2 F2 GRM7 GRM7 ZNF408 ZNF408 PLA2G4D PLA2G4D PDGFA PDGFA TSC2 TSC2 NRAS NRAS GRM4 GRM4 PLA2G4B PLA2G4B PDGFB PDGFB PIK3R3 PIK3R3 ENSMLEP00000031455 ENSMLEP00000031455 ENSMLEP00000031588 ENSMLEP00000031588 KIT KIT AVPR1B AVPR1B RRAS2 RRAS2 ARF1 ARF1 CYTH4 CYTH4 SYK SYK GNA13 GNA13 SPHK2 SPHK2 ENSMLEP00000033059 ENSMLEP00000033059 FCER1G FCER1G AGPAT1 AGPAT1 PIK3R1 PIK3R1 CYTH3 CYTH3 LPAR2 LPAR2 RAPGEF3 RAPGEF3 ENSMLEP00000035415 ENSMLEP00000035415 SHC1 SHC1 HRAS HRAS SHC2 SHC2 GRM5 GRM5 AKT3 AKT3 SRMS SRMS PLPP2 PLPP2 AVPR2 AVPR2 ADCY6 ADCY6 RAPGEF4 RAPGEF4 AGPAT2 AGPAT2 RHEBL1 RHEBL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAB2GRB2 associated binding protein 2. (667 aa)
CSDE1Cold shock domain containing E1. (844 aa)
ENSMLEP00000029152Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (219 aa)
JMJD7Jumonji domain containing 7. (316 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1276 aa)
GNA12G protein subunit alpha 12. (319 aa)
ENSMLEP00000028290Uncharacterized protein. (441 aa)
RHOARas homolog family member A. (193 aa)
LOC105540582Ras-GEF domain-containing protein. (407 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
ENSMLEP00000027485PID domain-containing protein. (488 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
GRM8Glutamate metabotropic receptor 8. (908 aa)
PLD2Phospholipase. (933 aa)
ENSMLEP00000026117annotation not available (172 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GRM1Glutamate metabotropic receptor 1. (961 aa)
DGKEDiacylglycerol kinase. (567 aa)
TSC1TSC complex subunit 1. (1162 aa)
LOC105533469Ras-GEF domain-containing protein. (540 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa)
SPHK1Sphingosine kinase 1. (470 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
ENSMLEP00000024790Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (294 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
PLD1Phospholipase. (1074 aa)
EGFRReceptor protein-tyrosine kinase. (1188 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1221 aa)
LOC105548340Uncharacterized protein. (246 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
PLA2G4CPhospholipase A2 group IVC. (469 aa)
DGKIDiacylglycerol kinase. (937 aa)
MS4A2Membrane spanning 4-domains A2. (245 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1317 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
ENSMLEP00000021624PIPK domain-containing protein. (457 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1299 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
AGPAT31-acylglycerol-3-phosphate O-acyltransferase 3. (376 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
CYTH2Uncharacterized protein. (400 aa)
CYTH1Cytohesin 1. (408 aa)
ENSMLEP00000018490Uncharacterized protein. (145 aa)
LOC105530438Ras-GEF domain-containing protein. (560 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
INSRTyrosine-protein kinase receptor. (1301 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (797 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (901 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (493 aa)
AGPAT41-acylglycerol-3-phosphate O-acyltransferase 4. (378 aa)
FYNTyrosine-protein kinase. (537 aa)
DGKKDiacylglycerol kinase. (1273 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (810 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (389 aa)
LOC105552366Ras-GEF domain-containing protein. (600 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (669 aa)
PLA2G4APhospholipase A2. (749 aa)
SHC4SHC adaptor protein 4. (630 aa)
PTGFRProstaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
GAB4GRB2 associated binding protein family member 4. (555 aa)
DGKGDiacylglycerol kinase. (791 aa)
ENSMLEP00000014023Ras-GEF domain-containing protein. (387 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (575 aa)
ENSMLEP00000012128Uncharacterized protein. (234 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1082 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
PLPP1Phospholipid phosphatase 1. (313 aa)
RALARAS like proto-oncogene A. (206 aa)
PTK6Tyrosine-protein kinase. (451 aa)
RHEBRas homolog, mTORC1 binding. (181 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (881 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
PLPP3acidPPc domain-containing protein. (311 aa)
PDGFDPlatelet derived growth factor D. (353 aa)
AGPAT51-acylglycerol-3-phosphate O-acyltransferase 5. (364 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
GPR55G protein-coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (319 aa)
RUFY4RUN and FYVE domain containing 4. (530 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
ERASES cell expressed Ras. (233 aa)
DGKZDiacylglycerol kinase. (1120 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (656 aa)
LPAR6Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (344 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1152 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
RRASRAS related. (218 aa)
FCER1AFc fragment of IgE receptor Ia. (257 aa)
DGKBDiacylglycerol kinase. (763 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
GRM2Glutamate metabotropic receptor 2. (872 aa)
RHOCRas homolog family member C. (193 aa)
DGKQDiacylglycerol kinase. (778 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
DGKADiacylglycerol kinase. (735 aa)
DGKHDiacylglycerol kinase. (1156 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
GNASGNAS complex locus. (998 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ENSMLEP00000003362Uncharacterized protein. (185 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
RALBRAS like proto-oncogene B. (212 aa)
PLA2G4FPhospholipase A2. (849 aa)
RALGDSUncharacterized protein. (911 aa)
PLA2G4EPhospholipase A2. (869 aa)
PIK3R2Uncharacterized protein. (587 aa)
SHC3SHC adaptor protein 3. (444 aa)
CEP152Centrosomal protein 152. (1709 aa)
RGL4Ras-GEF domain-containing protein. (591 aa)
DGKDDiacylglycerol kinase. (1181 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (353 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
GRM7Glutamate metabotropic receptor 7. (922 aa)
ZNF408Zinc finger protein 408. (719 aa)
PLA2G4DPhospholipase A2. (817 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (287 aa)
TSC2TSC complex subunit 2. (1807 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRM4Glutamate metabotropic receptor 4. (912 aa)
PLA2G4BPhospholipase A2. (781 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
ENSMLEP00000031455PIPK domain-containing protein. (487 aa)
ENSMLEP00000031588Ig-like domain-containing protein. (117 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
RRAS2RAS related 2. (176 aa)
ARF1ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
CYTH4Cytohesin 4. (397 aa)
SYKTyrosine-protein kinase. (618 aa)
GNA13G protein subunit alpha 13. (282 aa)
SPHK2Sphingosine kinase 2. (663 aa)
ENSMLEP00000033059Ig-like domain-containing protein. (153 aa)
FCER1GFc fragment of IgE receptor Ig. (112 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (283 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CYTH3Cytohesin 3. (361 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (925 aa)
ENSMLEP00000035415Uncharacterized protein. (519 aa)
SHC1SHC adaptor protein 1. (584 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SHC2Uncharacterized protein. (483 aa)
GRM5Glutamate metabotropic receptor 5. (1039 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SRMSTyrosine-protein kinase. (489 aa)
PLPP2Phospholipid phosphatase 2. (285 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (368 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (989 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (278 aa)
RHEBL1RHEB like 1. (183 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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