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| | ZBTB10 | Zinc finger and BTB domain containing 10. (737 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | CDK1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa) |
| | FBXW12 | F-box and WD repeat domain containing 12. (463 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1217 aa) |
| | CCNB3 | Cyclin B3; Belongs to the cyclin family. (1365 aa) |
| | RBX1 | RING-type domain-containing protein. (108 aa) |
| | ENSMLEP00000040613 | Protein kinase domain-containing protein. (286 aa) |
| | CDC26 | Cell division cycle 26. (85 aa) |
| | ENSMLEP00000006859 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (196 aa) |
| | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase. (1096 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | SKP1 | S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa) |
| | ANAPC5 | Anaphase promoting complex subunit 5. (755 aa) |
| | ENSMLEP00000008311 | Uncharacterized protein; Belongs to the SKP1 family. (142 aa) |
| | ANAPC13 | Anaphase promoting complex subunit 13. (74 aa) |
| | RBL1 | RB transcriptional corepressor like 1. (1038 aa) |
| | CCNB1 | Cyclin B1; Belongs to the cyclin family. (433 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (224 aa) |
| | CHEK2 | Checkpoint kinase 2. (558 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | YWHAQ | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (407 aa) |
| | TFDP1 | Transcription factor. (410 aa) |
| | SNAPIN | SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa) |
| | TTK | TTK protein kinase. (855 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | STAG1 | Stromal antigen 1. (1258 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | ENSMLEP00000013774 | Uncharacterized protein. (583 aa) |
| | CCNH | Cyclin H; Belongs to the cyclin family. (325 aa) |
| | ENSMLEP00000013869 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (214 aa) |
| | BUB3 | WD_REPEATS_REGION domain-containing protein. (328 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | ORC3 | Origin recognition complex subunit 3. (646 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | ANAPC11 | Anaphase promoting complex subunit 11. (165 aa) |
| | GADD45G | Growth arrest and DNA damage inducible gamma. (159 aa) |
| | ENSMLEP00000015919 | DOC domain-containing protein. (126 aa) |
| | ENSMLEP00000016498 | Transcription factor. (393 aa) |
| | MYNN | Myoneurin. (610 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | LOC105555268 | Protein kinase domain-containing protein. (542 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | CCNB2 | Cyclin B2; Belongs to the cyclin family. (398 aa) |
| | CHEK1 | Checkpoint kinase 1. (480 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa) |
| | ENSMLEP00000017703 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa) |
| | CDKN2A | Cyclin dependent kinase inhibitor 2A. (159 aa) |
| | YWHAZ | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | LOC105545834 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (470 aa) |
| | LOC105548148 | Protein kinase domain-containing protein. (312 aa) |
| | CDK7 | Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa) |
| | ORC5 | Origin recognition complex subunit 5. (421 aa) |
| | CDC14B | Cell division cycle 14B. (444 aa) |
| | CDC14C | Cell division cycle 14C. (558 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (242 aa) |
| | ORC6 | Origin recognition complex subunit 6. (203 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit. (3556 aa) |
| | PKMYT1 | Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (480 aa) |
| | RAD21L1 | RAD21 cohesin complex component like 1. (556 aa) |
| | PTTG2 | Pituitary tumor-transforming 2. (169 aa) |
| | CDC14A | Cell division cycle 14A. (624 aa) |
| | ZNF652 | Zinc finger protein 652. (606 aa) |
| | RB1 | RB transcriptional corepressor 1. (891 aa) |
| | CDK20 | Cyclin dependent kinase 20; Belongs to the protein kinase superfamily. (346 aa) |
| | YWHAH | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (223 aa) |
| | CDC27 | Cell division cycle 27. (834 aa) |
| | ENSMLEP00000022706 | Zf-rbx1 domain-containing protein. (93 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (603 aa) |
| | E2F5 | E2F transcription factor 5. (312 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | CDC25C | Cell division cycle 25C. (474 aa) |
| | STAG2 | Stromal antigen 2. (1268 aa) |
| | TMEM82 | Transmembrane protein 82. (315 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (2965 aa) |
| | FAM126B | Family with sequence similarity 126 member B. (530 aa) |
| | GADD45B | Growth arrest and DNA damage inducible beta. (176 aa) |
| | E2F3 | E2F transcription factor 3. (375 aa) |
| | CDC7 | Protein kinase domain-containing protein. (574 aa) |
| | SKP2 | S-phase kinase associated protein 2. (424 aa) |
| | ENSMLEP00000024146 | Uncharacterized protein. (136 aa) |
| | PTTG1 | PTTG1 regulator of sister chromatid separation, securin. (202 aa) |
| | LOC105528170 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (208 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa) |
| | LOC105530484 | Uncharacterized protein. (306 aa) |
| | SMC1A | Structural maintenance of chromosomes protein. (1233 aa) |
| | E2F4 | E2F transcription factor 4. (416 aa) |
| | MAD2L1 | Mitotic arrest deficient 2 like 1. (205 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | LOC105531290 | TPR_REGION domain-containing protein. (274 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1936 aa) |
| | CDKN2B | Cyclin dependent kinase inhibitor 2B. (157 aa) |
| | CNTD2 | Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (198 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (457 aa) |
| | CDC20 | Cell division cycle 20. (499 aa) |
| | LOC105529488 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (458 aa) |
| | ENSMLEP00000027534 | ANAPC8 domain-containing protein. (151 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (757 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (599 aa) |
| | RBL2 | RB transcriptional corepressor like 2. (1139 aa) |
| | CDC20B | Cell division cycle 20B. (477 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (861 aa) |
| | CDKN2C | Cyclin dependent kinase inhibitor 2C. (168 aa) |
| | ANAPC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (793 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (407 aa) |
| | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa) |
| | EP300 | E1A binding protein p300. (2411 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | ENSMLEP00000031844 | Uncharacterized protein. (347 aa) |
| | ORC2 | Origin recognition complex subunit 2. (577 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | ENSMLEP00000033047 | Uncharacterized protein. (67 aa) |
| | CDC45 | Cell division cycle 45. (598 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) |
| | ANAPC10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa) |
| | CDC16 | Cell division cycle 16. (606 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | CDC25A | Cell division cycle 25A. (524 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (853 aa) |
| | FZR1 | Fizzy and cell division cycle 20 related 1. (522 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | ENSMLEP00000036889 | Uncharacterized protein. (182 aa) |
| | LOC105541671 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (252 aa) |
| | ZBTB47 | Zinc finger and BTB domain containing 47. (748 aa) |
| | TGFB1 | Transforming growth factor beta 1. (226 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | ESPL1 | Extra spindle pole bodies like 1, separase. (2100 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa) |
| | CDC25B | Cell division cycle 25B. (522 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | WEE2 | Wee1-like protein kinase. (568 aa) |
| | AP5S1 | Adaptor related protein complex 5 subunit sigma 1. (200 aa) |
| | DBF4 | DBF4 zinc finger. (674 aa) |
| | BUB1B | BUB1 N-terminal domain-containing protein. (1050 aa) |
| | LOC105540906 | 14-3-3 protein sigma. (248 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa) |
| | E2F1 | E2F transcription factor 1. (381 aa) |
| | SMC1B | Structural maintenance of chromosomes protein. (1199 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | CREBBP | CREB binding protein. (2423 aa) |
| | LOC105540905 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa) |
| | ZBTB17 | Zinc finger and BTB domain containing 17. (807 aa) |
| | ZBTB46 | Zinc finger and BTB domain containing 46. (589 aa) |
