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TTC14 TTC14 ENSMLEP00000003274 ENSMLEP00000003274 LOC105550167 LOC105550167 MTOR MTOR GABARAPL2 GABARAPL2 ATG7 ATG7 ATG13 ATG13 ATG4B ATG4B ATG16L1 ATG16L1 ULK3 ULK3 ATG12 ATG12 ENSMLEP00000013771 ENSMLEP00000013771 PPP2CA PPP2CA ENSMLEP00000014760 ENSMLEP00000014760 ATG2A ATG2A ATG3 ATG3 WIPI2 WIPI2 ATG4A ATG4A ATG10 ATG10 ATG5 ATG5 ENSMLEP00000020759 ENSMLEP00000020759 ENSMLEP00000021070 ENSMLEP00000021070 LOC105529421 LOC105529421 PPP2CB PPP2CB ATG9B ATG9B GABARAPL1 GABARAPL1 GABARAP GABARAP ATG9A ATG9A ATG4D ATG4D ENSMLEP00000029005 ENSMLEP00000029005 MLST8 MLST8 ATG4C ATG4C RPTOR RPTOR ULK2 ULK2 WIPI1 WIPI1 PIK3R4 PIK3R4 ATG101 ATG101 ATG2B ATG2B IGBP1 IGBP1 BECN1 BECN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TTC14Tetratricopeptide repeat domain 14. (771 aa)
ENSMLEP00000003274Uncharacterized protein. (105 aa)
LOC105550167Uncharacterized protein. (298 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (704 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (403 aa)
ATG16L1Autophagy related 16 like 1. (624 aa)
ULK3Unc-51 like kinase 3. (482 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
ENSMLEP00000013771PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (104 aa)
PPP2CASerine/threonine-protein phosphatase. (275 aa)
ENSMLEP00000014760PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (94 aa)
ATG2AAutophagy related 2A. (1938 aa)
ATG3Autophagy-related protein 3. (314 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (258 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (398 aa)
ATG10Autophagy_act_C domain-containing protein. (112 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
ENSMLEP00000020759Uncharacterized protein. (90 aa)
ENSMLEP00000021070C2 PI3K-type domain-containing protein; Belongs to the PI3/PI4-kinase family. (201 aa)
LOC105529421Uncharacterized protein. (362 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (921 aa)
GABARAPL1GABA type A receptor associated protein like 1. (146 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (850 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (469 aa)
ENSMLEP00000029005ATG7_N domain-containing protein. (78 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1291 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1006 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (446 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
ATG101Autophagy related 101. (218 aa)
ATG2BAutophagy related 2B. (2079 aa)
IGBP1Immunoglobulin binding protein 1. (339 aa)
BECN1Beclin 1. (450 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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