STRINGSTRING
PPP2CB PPP2CB AKT2 AKT2 FOXO3 FOXO3 CPT1A CPT1A PPP2R5D PPP2R5D ENSMLEP00000023964 ENSMLEP00000023964 IGF1R IGF1R CPT1C CPT1C PFKFB4 PFKFB4 TSC1 TSC1 PIK3CD PIK3CD ELAVL1 ELAVL1 LIPE LIPE CPT1B CPT1B PRKAG2 PRKAG2 HNF4A HNF4A STK11 STK11 CCNA1 CCNA1 AKT1 AKT1 PIK3CB PIK3CB TBC1D1 TBC1D1 SCD SCD CREB5 CREB5 TSC2 TSC2 RAB10 RAB10 EIF4EBP1 EIF4EBP1 MAP3K7 MAP3K7 PIK3R3 PIK3R3 SREBF1 SREBF1 RPTOR RPTOR PFKFB1 PFKFB1 ADIPOR1 ADIPOR1 ENSMLEP00000033047 ENSMLEP00000033047 PRKAG1 PRKAG1 RAB8A RAB8A PPP2R2A PPP2R2A PRKAB2 PRKAB2 PIK3R1 PIK3R1 PFKFB3 PFKFB3 CCNA2 CCNA2 PRKAA1 PRKAA1 LEP LEP RAB2A RAB2A PPP2R5B PPP2R5B CFTR CFTR AKT1S1 AKT1S1 PCK2 PCK2 AKT3 AKT3 ULK1 ULK1 RAB2B RAB2B ADRA1A ADRA1A G6PC2 G6PC2 CREB3L2 CREB3L2 RHEBL1 RHEBL1 PPP2R1B PPP2R1B PPARG PPARG PCK1 PCK1 G6PC G6PC CAMKK2 CAMKK2 CREB3L1 CREB3L1 PIK3R2 PIK3R2 PPP2R5E PPP2R5E PPP2R2D PPP2R2D ENSMLEP00000002280 ENSMLEP00000002280 CREB3 CREB3 PFKM PFKM PRKAA2 PRKAA2 CAB39 CAB39 LEPR LEPR SIRT1 SIRT1 PPP2R5C PPP2R5C MTOR MTOR PRKAB1 PRKAB1 SCD5 SCD5 IGF1 IGF1 CREB3L3 CREB3L3 GYS1 GYS1 PPP2R2C PPP2R2C LOC105551588 LOC105551588 FASN FASN RPS6KB1 RPS6KB1 ACACA ACACA PPP2R5A PPP2R5A PRKAG3 PRKAG3 FBP1 FBP1 ENSMLEP00000008990 ENSMLEP00000008990 LOC105546272 LOC105546272 RPS6KB2 RPS6KB2 IRS4 IRS4 RHEB RHEB PPP2R2B PPP2R2B IRS1 IRS1 PPP2R3A PPP2R3A SLC2A4 SLC2A4 PPP2R1A PPP2R1A PDPK1 PDPK1 PFKL PFKL HMGCR HMGCR CD36 CD36 CREB3L4 CREB3L4 EEF2 EEF2 PPP2CA PPP2CA PFKFB2 PFKFB2 ENSMLEP00000015404 ENSMLEP00000015404 RAB14 RAB14 CAB39L CAB39L INS INS PFKP PFKP EEF2K EEF2K CRTC2 CRTC2 ADIPOR2 ADIPOR2 FBP2 FBP2 INSR INSR GAREM2 GAREM2 ENSMLEP00000018038 ENSMLEP00000018038 GYS2 GYS2 ENSMLEP00000018558 ENSMLEP00000018558 ADIPOQ ADIPOQ CREB1 CREB1 PIK3CA PIK3CA PPARGC1A PPARGC1A G6PC3 G6PC3 ENSMLEP00000020563 ENSMLEP00000020563 STRADA STRADA STRADB STRADB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FOXO3Forkhead box O3. (670 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (753 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
ENSMLEP00000023964Uncharacterized protein. (190 aa)
IGF1RTyrosine-protein kinase receptor. (1281 aa)
CPT1CCarnitine palmitoyltransferase 1C. (780 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4. (462 aa)
TSC1TSC complex subunit 1. (1162 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
LIPELipase E, hormone sensitive type. (1041 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (642 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (506 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (464 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
TBC1D1TBC1 domain family member 1. (1169 aa)
SCDUncharacterized protein; Belongs to the fatty acid desaturase type 1 family. (359 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
TSC2TSC complex subunit 2. (1807 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (73 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1124 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1291 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
ENSMLEP00000033047Uncharacterized protein. (67 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (326 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (560 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
RAB2ARAB2A, member RAS oncogene family. (196 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (502 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1484 aa)
AKT1S1AKT1 substrate 1. (276 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ULK1Unc-51 like autophagy activating kinase 1. (996 aa)
RAB2BRAB2B, member RAS oncogene family. (216 aa)
ADRA1AAdrenoceptor alpha 1A. (466 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
RHEBL1RHEB like 1. (183 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (637 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (517 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (466 aa)
PIK3R2Uncharacterized protein. (587 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (468 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (466 aa)
ENSMLEP00000002280Biotin carboxylation domain-containing protein. (205 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
CAB39Calcium binding protein 39. (341 aa)
LEPRLeptin receptor. (1163 aa)
SIRT1Sirtuin 1. (661 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (580 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (257 aa)
IGF1Insulin like growth factor 1. (159 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (321 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
LOC105551588Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (455 aa)
FASNFatty acid synthase. (2510 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (525 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (298 aa)
ENSMLEP00000008990Uncharacterized protein. (858 aa)
LOC105546272PFK domain-containing protein. (189 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
IRS4Insulin receptor substrate 4. (1245 aa)
RHEBRas homolog, mTORC1 binding. (181 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (529 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (779 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (422 aa)
EEF2Eukaryotic translation elongation factor 2. (858 aa)
PPP2CASerine/threonine-protein phosphatase. (275 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. (522 aa)
ENSMLEP00000015404Fork-head domain-containing protein. (531 aa)
RAB14RAB14, member RAS oncogene family. (215 aa)
CAB39LCalcium binding protein 39 like. (377 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (775 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
CRTC2CREB regulated transcription coactivator 2. (694 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
INSRTyrosine-protein kinase receptor. (1301 aa)
GAREM2GRB2 associated regulator of MAPK1 subtype 2. (666 aa)
ENSMLEP00000018038Uncharacterized protein. (427 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
ENSMLEP00000018558Tr-type G domain-containing protein. (313 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (249 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
ENSMLEP00000020563Uncharacterized protein; Belongs to the fatty acid desaturase type 1 family. (346 aa)
STRADASTE20 related adaptor alpha. (431 aa)
STRADBSTE20 related adaptor beta. (377 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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