STRINGSTRING
ENSMLEP00000024790 ENSMLEP00000024790 HSPA2 HSPA2 NRAS NRAS PIK3R3 PIK3R3 RPTOR RPTOR KCNK1 KCNK1 PRKACB PRKACB HDAC2 HDAC2 PRKAG1 PRKAG1 PRKAB2 PRKAB2 PIK3R1 PIK3R1 PRKAA1 PRKAA1 HRAS HRAS AKT1S1 AKT1S1 AKT3 AKT3 ADCY6 ADCY6 HDAC1 HDAC1 CSDE1 CSDE1 LOC105542708 LOC105542708 PIK3CB PIK3CB AKT1 AKT1 LOC105529488 LOC105529488 PRKAG2 PRKAG2 ADCY3 ADCY3 PIK3CD PIK3CD ADCY5 ADCY5 CAT CAT IGF1R IGF1R ADCY1 ADCY1 ENSMLEP00000022796 ENSMLEP00000022796 TIMM8B TIMM8B FOXO3 FOXO3 AKT2 AKT2 TIMM8A TIMM8A SOD1 SOD1 EIF4EBP2 EIF4EBP2 PRKACA PRKACA ATG5 ATG5 PIK3CA PIK3CA LOC105535402 LOC105535402 LOC105545834 LOC105545834 INSR INSR ADCY2 ADCY2 ENSMLEP00000016358 ENSMLEP00000016358 INS INS HSPA8 HSPA8 ENSMLEP00000015404 ENSMLEP00000015404 SOD2 SOD2 FOXA2 FOXA2 LOC105549560 LOC105549560 IRS1 IRS1 IRS4 IRS4 RPS6KB2 RPS6KB2 KRAS KRAS PRKAG3 PRKAG3 CRYAB CRYAB RPS6KB1 RPS6KB1 ERAS ERAS IGF1 IGF1 PRKAB1 PRKAB1 MTOR MTOR ADCY8 ADCY8 SIRT1 SIRT1 HSPA1L HSPA1L ENSMLEP00000003717 ENSMLEP00000003717 CLPB CLPB PRKAA2 PRKAA2 ADCY7 ADCY7 ADCY9 ADCY9 ADCY4 ADCY4 PIK3R2 PIK3R2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMLEP00000024790Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (294 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (600 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1291 aa)
KCNK1Potassium channel subfamily K member. (336 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (326 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AKT1S1AKT1 substrate 1. (276 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
CSDE1Cold shock domain containing E1. (844 aa)
LOC105542708Uncharacterized protein. (462 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
LOC105529488Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (458 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (506 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
IGF1RTyrosine-protein kinase receptor. (1281 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
ENSMLEP00000022796Uncharacterized protein. (111 aa)
TIMM8BTranslocase of inner mitochondrial membrane 8 homolog B; Belongs to the small Tim family. (97 aa)
FOXO3Forkhead box O3. (670 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TIMM8Azf-Tim10_DDP domain-containing protein; Belongs to the small Tim family. (97 aa)
SOD1Superoxide dismutase 1. (129 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2. (71 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC105535402Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
LOC105545834Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (470 aa)
INSRTyrosine-protein kinase receptor. (1301 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (901 aa)
ENSMLEP00000016358Uncharacterized protein. (419 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
ENSMLEP00000015404Fork-head domain-containing protein. (531 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (236 aa)
FOXA2Forkhead box A2. (463 aa)
LOC105549560Uncharacterized protein; Belongs to the heat shock protein 70 family. (594 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
IRS4Insulin receptor substrate 4. (1245 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ERASES cell expressed Ras. (233 aa)
IGF1Insulin like growth factor 1. (159 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
SIRT1Sirtuin 1. (661 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
ENSMLEP00000003717zf-Tim10_DDP domain-containing protein; Belongs to the small Tim family. (97 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (712 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
PIK3R2Uncharacterized protein. (587 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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