58 items (Mandrillus leucophaeus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CSNK1G2	Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (242 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	LMBR1L	Limb development membrane protein 1 like; Belongs to the LIMR family. (489 aa)
	LRP4	LDL receptor related protein 4. (1822 aa)
	SPOP	Speckle type BTB/POZ protein. (374 aa)
	GLI1	GLI family zinc finger 1. (1106 aa)
	CSNK1G3	Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (455 aa)
	ENSMLEP00000037023	HH_signal domain-containing protein. (126 aa)
	EVC2	EvC ciliary complex subunit 2. (1252 aa)
	SMURF1	E3 ubiquitin-protein ligase. (748 aa)
	CSNK1A1L	Casein kinase 1 alpha 1 like. (243 aa)
	CCND2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
	ENSMLEP00000033047	Uncharacterized protein. (67 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	CDON	Cell adhesion associated, oncogene regulated. (1287 aa)
	ARRB1	Arrestin beta 1. (417 aa)
	MEGF8	Multiple EGF like domains 8. (2846 aa)
	ATRN	Attractin. (1408 aa)
	LOC105538880	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	ARR3	Arrestin 3. (389 aa)
	MGRN1	Mahogunin ring finger 1. (492 aa)
	ATRNL1	Attractin like 1. (1167 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
	GRK3	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (669 aa)
	GPR161	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (550 aa)
	FBXW11	F-box and WD repeat domain containing 11. (546 aa)
	GRK2	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (701 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
	TSPAN33	Tetraspanin. (249 aa)
	ENSMLEP00000019571	Protein kinase domain-containing protein. (324 aa)
	LOC105545975	Uncharacterized protein. (448 aa)
	PTCH1	Patched 1. (1379 aa)
	KIF3A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (726 aa)
	KIF7	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1243 aa)
	CSNK1A1	Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (358 aa)
	ENSMLEP00000015812	Uncharacterized protein. (66 aa)
	EVC	EvC ciliary complex subunit 1. (934 aa)
	CSNK1G1	Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (475 aa)
	LMBR1	Limb development membrane protein 1; Belongs to the LIMR family. (509 aa)
	SPOPL	Speckle type BTB/POZ protein like. (392 aa)
	ARRB2	Arrestin beta 2. (478 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (506 aa)
	CSNK1D	Casein kinase 1 delta. (434 aa)
	DHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
	LRP2	LDL receptor related protein 2. (4655 aa)
	HHIP	Hedgehog interacting protein. (700 aa)
	BOC	BOC cell adhesion associated, oncogene regulated. (1114 aa)
	MOSMO	Modulator of smoothened. (167 aa)
	KIF27	Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1401 aa)
	GLI3	GLI family zinc finger 3. (1580 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (767 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	SMURF2	SMAD specific E3 ubiquitin protein ligase 2. (624 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (785 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (398 aa)
	PTCH2	Patched 2. (1203 aa)
	GLI2	GLI family zinc finger 2. (1585 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARR3	GLI1	ENSMLEP00000025296	ENSMLEP00000038066	Arrestin 3.	GLI family zinc finger 1.	0.544
ARR3	GLI2	ENSMLEP00000025296	ENSMLEP00000000403	Arrestin 3.	GLI family zinc finger 2.	0.530
ARR3	GLI3	ENSMLEP00000025296	ENSMLEP00000008605	Arrestin 3.	GLI family zinc finger 3.	0.522
ARR3	GPR161	ENSMLEP00000025296	ENSMLEP00000022783	Arrestin 3.	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	0.592
ARR3	GRK2	ENSMLEP00000025296	ENSMLEP00000021052	Arrestin 3.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.597
ARR3	GRK3	ENSMLEP00000025296	ENSMLEP00000023041	Arrestin 3.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.504
ARR3	KIF3A	ENSMLEP00000025296	ENSMLEP00000017917	Arrestin 3.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.602
ARR3	SMO	ENSMLEP00000025296	ENSMLEP00000003293	Arrestin 3.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.698
ARRB1	ARRB2	ENSMLEP00000029248	ENSMLEP00000013259	Arrestin beta 1.	Arrestin beta 2.	0.958
ARRB1	GLI1	ENSMLEP00000029248	ENSMLEP00000038066	Arrestin beta 1.	GLI family zinc finger 1.	0.898
ARRB1	GLI2	ENSMLEP00000029248	ENSMLEP00000000403	Arrestin beta 1.	GLI family zinc finger 2.	0.894
ARRB1	GLI3	ENSMLEP00000029248	ENSMLEP00000008605	Arrestin beta 1.	GLI family zinc finger 3.	0.893
ARRB1	GPR161	ENSMLEP00000029248	ENSMLEP00000022783	Arrestin beta 1.	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	0.909
ARRB1	GRK2	ENSMLEP00000029248	ENSMLEP00000021052	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.942
ARRB1	GRK3	ENSMLEP00000029248	ENSMLEP00000023041	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.913
ARRB1	KIF3A	ENSMLEP00000029248	ENSMLEP00000017917	Arrestin beta 1.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.941
ARRB1	PRKACA	ENSMLEP00000029248	ENSMLEP00000020813	Arrestin beta 1.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.485
ARRB1	PRKACB	ENSMLEP00000029248	ENSMLEP00000032707	Arrestin beta 1.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.485
ARRB1	SMO	ENSMLEP00000029248	ENSMLEP00000003293	Arrestin beta 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.950
ARRB2	ARRB1	ENSMLEP00000013259	ENSMLEP00000029248	Arrestin beta 2.	Arrestin beta 1.	0.958