STRINGSTRING
TGFBR1 TGFBR1 PIK3R6 PIK3R6 JAG1 JAG1 MTOR MTOR ADCY8 ADCY8 PLAT PLAT CALML3 CALML3 LOC105540811 LOC105540811 PRKAA2 PRKAA2 ADCY7 ADCY7 ADCY9 ADCY9 SLC9A1 SLC9A1 ENSMLEP00000003274 ENSMLEP00000003274 GNB4 GNB4 UCP2 UCP2 ADCY4 ADCY4 ENSMLEP00000002165 ENSMLEP00000002165 MYL3 MYL3 ENSMLEP00000001951 ENSMLEP00000001951 MEF2B MEF2B APLNR APLNR SLC8A1 SLC8A1 AKT2 AKT2 CAMK4 CAMK4 MEF2C MEF2C LOC105548088 LOC105548088 ITPR3 ITPR3 PLIN1 PLIN1 GNB5 GNB5 PLCB2 PLCB2 MAPK1 MAPK1 GNB2 GNB2 ADCY1 ADCY1 AGTR1 AGTR1 ENSMLEP00000024790 ENSMLEP00000024790 ENSMLEP00000024805 ENSMLEP00000024805 SPHK1 SPHK1 HDAC4 HDAC4 ADCY5 ADCY5 GNGT2 GNGT2 HDAC5 HDAC5 GNAI3 GNAI3 LIPE LIPE ADCY3 ADCY3 GABARAPL1 GABARAPL1 PRKAG2 PRKAG2 SMAD2 SMAD2 NOS2 NOS2 AKT1 AKT1 ENSMLEP00000028401 ENSMLEP00000028401 GABARAP GABARAP GNG12 GNG12 CSDE1 CSDE1 GNG5 GNG5 LOC105549202 LOC105549202 GNG3 GNG3 RYR1 RYR1 ENSMLEP00000029948 ENSMLEP00000029948 NRAS NRAS EFCAB13 EFCAB13 MYL4 MYL4 SERPINE1 SERPINE1 EFCAB3 EFCAB3 GNG4 GNG4 ENSMLEP00000031736 ENSMLEP00000031736 RRAS2 RRAS2 RPS6 RPS6 GNA13 GNA13 SPHK2 SPHK2 PRKACB PRKACB FBXO21 FBXO21 ENSMLEP00000033047 ENSMLEP00000033047 CALM3 CALM3 PRKAG1 PRKAG1 MEF2A MEF2A GNGT1 GNGT1 PRKAB2 PRKAB2 GNAI1 GNAI1 PRKAA1 PRKAA1 CDH1 CDH1 RRAD RRAD GNG8 GNG8 SLC8A2 SLC8A2 PIK3R4 PIK3R4 HRAS HRAS ENSMLEP00000036527 ENSMLEP00000036527 AKT3 AKT3 GNG13 GNG13 MYLK4 MYLK4 ADCY6 ADCY6 MEF2D MEF2D ENSMLEP00000038520 ENSMLEP00000038520 RYR3 RYR3 PLCB3 PLCB3 PDE3B PDE3B UCP3 UCP3 NRF1 NRF1 CALML6 CALML6 BECN1 BECN1 PRKAB1 PRKAB1 GABARAPL2 GABARAPL2 REM1 REM1 RRAS RRAS GNAI2 GNAI2 ITPR2 ITPR2 GNB3 GNB3 ERAS ERAS RPS6KB1 RPS6KB1 ENSMLEP00000007417 ENSMLEP00000007417 PLCB1 PLCB1 SMAD4 SMAD4 CCN2 CCN2 PRKAG3 PRKAG3 KRAS KRAS RPS6KB2 RPS6KB2 GNG2 GNG2 LOC105550079 LOC105550079 PIK3R5 PIK3R5 PLCB4 PLCB4 APLN APLN GNAQ GNAQ ITPR1 ITPR1 RYR2 RYR2 CALM1 CALM1 MYLK2 MYLK2 SPP1 SPP1 RAF1 RAF1 PIK3CG PIK3CG EGR1 EGR1 NOS1 NOS1 SNAPIN SNAPIN UCP1 UCP1 NOTCH3 NOTCH3 MYLK3 MYLK3 GEM GEM ENSMLEP00000013771 ENSMLEP00000013771 NOS3 NOS3 MYLK MYLK SLC8A3 SLC8A3 ENSMLEP00000014760 ENSMLEP00000014760 MYL2 MYL2 TFAM TFAM MAP2K2 MAP2K2 PRKCE PRKCE ADCY2 ADCY2 PLIN3 PLIN3 SMAD3 SMAD3 PVALEF PVALEF ADCY10 ADCY10 CALM2 CALM2 MAP2K1 MAP2K1 GNB1 GNB1 PPARGC1A PPARGC1A CALML4 CALML4 PRKACA PRKACA MRAS MRAS TMEM145 TMEM145 ENSMLEP00000021070 ENSMLEP00000021070 MAPK3 MAPK3 ENSMLEP00000021430 ENSMLEP00000021430
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
LOC105540811Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
ENSMLEP00000003274Uncharacterized protein. (105 aa)
GNB4G protein subunit beta 4. (340 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ENSMLEP00000002165Uncharacterized protein; Belongs to the calmodulin family. (95 aa)
MYL3Myosin light chain 3. (228 aa)
ENSMLEP00000001951Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (60 aa)
MEF2BMyocyte enhancer factor 2B. (381 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
LOC105548088Titin. (30818 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
PLIN1Perilipin; Belongs to the perilipin family. (431 aa)
GNB5G protein subunit beta 5. (357 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
GNB2G protein subunit beta 2. (340 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
ENSMLEP00000024790Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (294 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
SPHK1Sphingosine kinase 1. (470 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1085 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1123 aa)
GNAI3G protein subunit alpha i3. (354 aa)
LIPELipase E, hormone sensitive type. (1041 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
GABARAPL1GABA type A receptor associated protein like 1. (146 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (506 aa)
SMAD2Mothers against decapentaplegic homolog. (457 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1147 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
ENSMLEP00000028401Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (65 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CSDE1Cold shock domain containing E1. (844 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LOC10554920240S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (244 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
RYR1Ryanodine receptor 1. (4628 aa)
ENSMLEP00000029948EF-hand domain-containing protein; Belongs to the calmodulin family. (73 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
EFCAB13EF-hand calcium binding domain 13. (973 aa)
MYL4Myosin light chain 4. (195 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
EFCAB3EF-hand calcium binding domain 3. (488 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ENSMLEP0000003173640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (222 aa)
RRAS2RAS related 2. (176 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (218 aa)
GNA13G protein subunit alpha 13. (282 aa)
SPHK2Sphingosine kinase 2. (663 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
FBXO21F-box protein 21. (537 aa)
ENSMLEP00000033047Uncharacterized protein. (67 aa)
CALM3Calmodulin 3. (149 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (326 aa)
MEF2AMyocyte enhancer factor 2A. (513 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
GNAI1G protein subunit alpha i1. (314 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
CDH1Cadherin 1. (628 aa)
RRADRRAD, Ras related glycolysis inhibitor and calcium channel regulator. (248 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ENSMLEP00000036527Uncharacterized protein. (89 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (388 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
ENSMLEP00000038520Uncharacterized protein; Belongs to the calmodulin family. (91 aa)
RYR3Ryanodine receptor 3. (4804 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
PDE3BPhosphodiesterase. (1113 aa)
UCP3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (312 aa)
NRF1Nuclear respiratory factor 1. (522 aa)
CALML6Calmodulin like 6. (181 aa)
BECN1Beclin 1. (450 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
RRASRAS related. (218 aa)
GNAI2G protein subunit alpha i2. (352 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2663 aa)
GNB3G protein subunit beta 3. (340 aa)
ERASES cell expressed Ras. (233 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ENSMLEP00000007417Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CCN2Cellular communication network factor 2. (295 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
LOC105550079Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (881 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
APLNApelin. (77 aa)
GNAQG protein subunit alpha q. (313 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2731 aa)
RYR2Ryanodine receptor 2. (4862 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
MYLK2Myosin light chain kinase 2. (595 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1082 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1404 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
NOTCH3Notch receptor 3. (2185 aa)
MYLK3Myosin light chain kinase 3. (819 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
ENSMLEP00000013771PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (104 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1155 aa)
MYLKMyosin light chain kinase. (1912 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
ENSMLEP00000014760PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (94 aa)
MYL2Myosin light chain 2. (166 aa)
TFAMTranscription factor A, mitochondrial. (248 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (389 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (901 aa)
PLIN3Perilipin; Belongs to the perilipin family. (427 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
ADCY10Adenylate cyclase 10. (1517 aa)
CALM2Calmodulin 2. (149 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GNB1G protein subunit beta 1. (340 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
CALML4Calmodulin like 4. (193 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
TMEM145Transmembrane protein 145. (453 aa)
ENSMLEP00000021070C2 PI3K-type domain-containing protein; Belongs to the PI3/PI4-kinase family. (201 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
ENSMLEP0000002143040S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (210 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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