STRINGSTRING
ACVR2A ACVR2A ZIC3 ZIC3 TBX3 TBX3 NFIL3 NFIL3 BMPR2 BMPR2 WNT1 WNT1 FZD2 FZD2 PIK3R2 PIK3R2 ISL2 ISL2 WNT11 WNT11 REST REST WNT9B WNT9B KAT6A KAT6A NEUROG1 NEUROG1 INHBA INHBA WNT10B WNT10B ENSMLEP00000005746 ENSMLEP00000005746 ACVR1B ACVR1B IGF1 IGF1 ISL1 ISL1 LOC105532400 LOC105532400 FZD7 FZD7 ERAS ERAS FGFR2 FGFR2 TCF3 TCF3 SMAD4 SMAD4 DVL1 DVL1 FGFR4 FGFR4 KRAS KRAS FZD6 FZD6 CTNNB1 CTNNB1 AXIN2 AXIN2 WNT8A WNT8A LOC105534402 LOC105534402 ACVR2B ACVR2B WNT4 WNT4 WNT2 WNT2 LIF LIF OTX1 OTX1 FGFR1 FGFR1 RAF1 RAF1 PAX6 PAX6 KLF4 KLF4 STAT3 STAT3 LOC105552331 LOC105552331 FGFR3 FGFR3 JAK2 JAK2 LHX1 LHX1 HAND1 HAND1 INHBC INHBC NODAL NODAL MAP2K2 MAP2K2 AXIN1 AXIN1 SMAD3 SMAD3 WNT8B WNT8B WNT2B WNT2B MYC MYC GRB2 GRB2 JARID2 JARID2 ENSMLEP00000024805 ENSMLEP00000024805 GSK3B GSK3B APC2 APC2 IGF1R IGF1R SMAD9 SMAD9 MAPK1 MAPK1 HOXD1 HOXD1 MAPK11 MAPK11 HOXA1 HOXA1 AKT2 AKT2 DVL2 DVL2 IL6ST IL6ST ONECUT1 ONECUT1 BMPR1A BMPR1A MAPK3 MAPK3 MEIS1 MEIS1 ACVR1C ACVR1C JAK3 JAK3 TBX2 TBX2 ONECUT2 ONECUT2 MAP2K1 MAP2K1 WNT3A WNT3A PIK3CA PIK3CA LOC105547669 LOC105547669 SMAD1 SMAD1 DVL3 DVL3 BMPR1B BMPR1B SMAD5 SMAD5 FGF2 FGF2 SETDB1 SETDB1 ENSMLEP00000029949 ENSMLEP00000029949 PCGF6 PCGF6 CSDE1 CSDE1 JAK1 JAK1 SMARCAD1 SMARCAD1 PIK3CB PIK3CB WNT7B WNT7B HESX1 HESX1 PCGF5 PCGF5 LOC105534482 LOC105534482 PIK3CD PIK3CD LIFR LIFR SKIL SKIL PCGF3 PCGF3 ACVR1 ACVR1 HOXB1 HOXB1 WNT5B WNT5B TCF7 TCF7 MAPK12 MAPK12 SMAD2 SMAD2 AKT1 AKT1 WNT6 WNT6 MYF5 MYF5 WNT5A WNT5A INHBE INHBE WNT3 WNT3 LEFTY2 LEFTY2 BMP4 BMP4 ESX1 ESX1 MAPK14 MAPK14 ID1 ID1 ZIC1 ZIC1 RIF1 RIF1 AKT3 AKT3 ZFHX3 ZFHX3 DUSP9 DUSP9 WNT7A WNT7A PCGF1 PCGF1 PRRX1 PRRX1 HRAS HRAS WNT9A WNT9A ID3 ID3 POU5F1 POU5F1 PCGF2 PCGF2 ESRRB ESRRB PIK3R1 PIK3R1 APC APC FZD4 FZD4 ESRRG ESRRG ID2 ID2 MAPK13 MAPK13 WNT16 WNT16 LOC105537533 LOC105537533 FZD3 FZD3 FZD10 FZD10 ZIC2 ZIC2 WNT10A WNT10A PIK3R3 PIK3R3 MEIS2 MEIS2 NRAS NRAS DLX5 DLX5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ZIC3Zic family member 3. (466 aa)
TBX3T-box transcription factor 3. (743 aa)
NFIL3Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...] (462 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1032 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (287 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
PIK3R2Uncharacterized protein. (587 aa)
ISL2ISL LIM homeobox 2. (329 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (289 aa)
RESTRE1 silencing transcription factor. (1095 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2003 aa)
NEUROG1Neurogenin 1. (237 aa)
INHBAInhibin subunit beta A. (426 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ENSMLEP00000005746Homeobox domain-containing protein. (153 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
IGF1Insulin like growth factor 1. (159 aa)
ISL1ISL LIM homeobox 1. (349 aa)
LOC105532400Homeobox domain-containing protein. (254 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (553 aa)
ERASES cell expressed Ras. (233 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
TCF3BHLH domain-containing protein. (616 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
DVL1Dishevelled segment polarity protein 1. (591 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
CTNNB1Catenin beta 1. (781 aa)
AXIN2Axin 2. (843 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
LOC105534402BHLH domain-containing protein. (589 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
OTX1Orthodenticle homeobox 1. (288 aa)
FGFR1Fibroblast growth factor receptor. (853 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PAX6Paired box 6. (520 aa)
KLF4Uncharacterized protein. (145 aa)
STAT3Signal transducer and activator of transcription. (693 aa)
LOC105552331Left-right determination factor. (366 aa)
FGFR3Fibroblast growth factor receptor. (771 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
LHX1LIM homeobox 1. (406 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
INHBCInhibin subunit beta C. (352 aa)
NODALNodal growth differentiation factor. (303 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (389 aa)
AXIN1Axin 1. (859 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1235 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
APC2APC regulator of WNT signaling pathway 2. (1668 aa)
IGF1RTyrosine-protein kinase receptor. (1281 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
HOXD1Homeobox D1. (249 aa)
MAPK11Mitogen-activated protein kinase. (224 aa)
HOXA1Homeobox A1. (335 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
ONECUT1One cut domain family member. (403 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
MEIS1Meis homeobox 1. (463 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
JAK3Tyrosine-protein kinase. (1030 aa)
TBX2T-box transcription factor 2. (586 aa)
ONECUT2One cut domain family member. (464 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC105547669RING-type domain-containing protein. (326 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
DVL3Dishevelled segment polarity protein 3. (731 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1291 aa)
ENSMLEP00000029949Uncharacterized protein. (265 aa)
PCGF6Polycomb group ring finger 6. (331 aa)
CSDE1Cold shock domain containing E1. (844 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
SMARCAD1Uncharacterized protein. (1026 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
HESX1HESX homeobox 1. (185 aa)
PCGF5Polycomb group ring finger 5. (256 aa)
LOC105534482Homeobox domain-containing protein. (292 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LIFRLIF receptor subunit alpha. (1097 aa)
SKILSKI like proto-oncogene. (684 aa)
PCGF3Polycomb group ring finger 3. (242 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
HOXB1Homeobox B1. (304 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
TCF7Transcription factor 7. (269 aa)
MAPK12Mitogen-activated protein kinase. (292 aa)
SMAD2Mothers against decapentaplegic homolog. (457 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
INHBEInhibin subunit beta E. (351 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LEFTY2Left-right determination factor. (366 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ESX1ESX homeobox 1. (358 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
ZIC1Zic family member 1. (447 aa)
RIF1Replication timing regulatory factor 1. (2466 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ZFHX3Zinc finger homeobox 3. (3689 aa)
DUSP9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (297 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
PRRX1Paired related homeobox 1. (245 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
POU5F1POU domain protein. (360 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
ESRRBEstrogen related receptor beta. (508 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
APCAPC regulator of WNT signaling pathway. (2806 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (533 aa)
ESRRGEstrogen related receptor gamma. (470 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
MAPK13Mitogen-activated protein kinase. (397 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
LOC105537533Homeobox domain-containing protein. (285 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
ZIC2Zic family member 2. (286 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MEIS2Meis homeobox 2. (477 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
DLX5Distal-less homeobox 5. (289 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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