(87 nodes) Antigen processing and presentation network (Mandrillus leucophaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105551614	Uncharacterized protein. (442 aa)
	LOC105531108	Ig-like domain-containing protein; Belongs to the MHC class II family. (269 aa)
	LOC105538379	HATPase_c domain-containing protein. (673 aa)
	CTSL	Cathepsin L; Belongs to the peptidase C1 family. (333 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (339 aa)
	LOC105551610	Uncharacterized protein. (452 aa)
	ENSMLEP00000026510	Ig-like domain-containing protein; Belongs to the MHC class I family. (301 aa)
	PSME1	Proteasome activator subunit 1. (284 aa)
	CD8B	Ig-like domain-containing protein. (243 aa)
	RFXAP	Regulatory factor X associated protein. (272 aa)
	HLA-DOA	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (331 aa)
	LOC105542545	HATPase_c domain-containing protein. (626 aa)
	KLRG1	Killer cell lectin like receptor G1. (189 aa)
	KLRD1	Killer cell lectin like receptor D1. (179 aa)
	ENSMLEP00000028396	IGc1 domain-containing protein. (205 aa)
	NFYC	Nuclear transcription factor Y subunit gamma. (439 aa)
	LOC105542708	Uncharacterized protein. (462 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (600 aa)
	ENSMLEP00000031001	Ig-like domain-containing protein; Belongs to the MHC class I family. (333 aa)
	HLA-DMA	Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (290 aa)
	TRAC	T cell receptor alpha constant. (110 aa)
	TAP2	Transporter 2, ATP binding cassette subfamily B member. (703 aa)
	ENSMLEP00000031869	CBFD_NFYB_HMF domain-containing protein. (183 aa)
	HSP90AA1	Heat shock protein 90 alpha family class A member 1. (823 aa)
	LOC105536146	Ig-like domain-containing protein. (327 aa)
	CANX	Calnexin. (592 aa)
	PSME2	Proteasome activator subunit 2. (239 aa)
	ENSMLEP00000035626	Ig-like domain-containing protein; Belongs to the MHC class I family. (313 aa)
	TAP1	Transporter 1, ATP binding cassette subfamily B member. (738 aa)
	LOC105540670	Ig-like domain-containing protein. (261 aa)
	KLRC1	C-type lectin domain-containing protein. (233 aa)
	IFI30	IFI30 lysosomal thiol reductase. (250 aa)
	CALR	Calreticulin. (417 aa)
	ENSMLEP00000038532	Uncharacterized protein. (260 aa)
	HLA-DOB	Major histocompatibility complex, class II, DO beta. (273 aa)
	LOC105554720	HATPase_c domain-containing protein. (658 aa)
	HLA-E	Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (364 aa)
	RFXANK	Regulatory factor X associated ankyrin containing protein. (260 aa)
	HLA-DRA	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
	LOC105537709	Ig-like domain-containing protein; Belongs to the MHC class II family. (256 aa)
	PSME3	Proteasome activator subunit 3. (267 aa)
	LOC105537163	Ig-like domain-containing protein. (264 aa)
	ENSMLEP00000003171	C-type lectin domain-containing protein. (231 aa)
	CD8A	CD8a molecule. (235 aa)
	HSPA4	Heat shock protein family A (Hsp70) member 4. (840 aa)
	HSPA1L	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
	LOC105537710	Ig-like domain-containing protein. (228 aa)
	ENSMLEP00000005644	Ig-like domain-containing protein; Belongs to the MHC class I family. (216 aa)
	HSP90AB1	Heat shock protein 90 alpha family class B member 1. (724 aa)
	TAPBP	TAP binding protein. (504 aa)
	CIITA	Class II major histocompatibility complex transactivator. (1129 aa)
	KIR2DL4	Uncharacterized protein. (369 aa)
	LOC105540228	Ig-like domain-containing protein. (258 aa)
	LOC105551601	Uncharacterized protein. (360 aa)
	LOC105535298	Ig-like domain-containing protein; Belongs to the MHC class I family. (345 aa)
	LOC105533269	MHC_I_C domain-containing protein. (93 aa)
	PDIA3	Protein disulfide-isomerase. (485 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
	LOC105540229	Ig-like domain-containing protein; Belongs to the MHC class II family. (269 aa)
	NFYB	CBFD_NFYB_HMF domain-containing protein. (208 aa)
	LOC105549560	Uncharacterized protein; Belongs to the heat shock protein 70 family. (594 aa)
	ENSMLEP00000011359	Uncharacterized protein. (384 aa)
	RFX5	Regulatory factor X5. (621 aa)
	ENSMLEP00000012170	Ig-like domain-containing protein. (147 aa)
	ENSMLEP00000012897	Uncharacterized protein. (303 aa)
	ENSMLEP00000013020	Uncharacterized protein. (70 aa)
	ENSMLEP00000014987	IGc1 domain-containing protein; Belongs to the MHC class I family. (327 aa)
	HSPA8	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
	ENSMLEP00000016260	MHC_I-like_Ag-recog domain-containing protein. (163 aa)
	ENSMLEP00000016358	Uncharacterized protein. (419 aa)
	ENSMLEP00000017019	MHC_I-like_Ag-recog domain-containing protein. (157 aa)
	LGMN	Legumain. (404 aa)
	CD4	CD4 molecule. (458 aa)
	LOC105531112	Ig-like domain-containing protein. (263 aa)
	LOC105535402	Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
	NFYA	Nuclear transcription factor Y subunit alpha. (347 aa)
	LOC105537711	Ig-like domain-containing protein. (266 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	ENSMLEP00000019778	IGc1 domain-containing protein; Belongs to the MHC class I family. (327 aa)
	LOC105537712	Ig-like domain-containing protein. (239 aa)
	LOC105553177	Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
	CD74	CD74 molecule. (294 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
	ENSMLEP00000022361	Uncharacterized protein; Belongs to the heat shock protein 70 family. (580 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	LOC105551611	Uncharacterized protein. (447 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	CALR	ENSMLEP00000010574	ENSMLEP00000037878	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Calreticulin.	0.855
B2M	CANX	ENSMLEP00000010574	ENSMLEP00000033815	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Calnexin.	0.583
B2M	CD4	ENSMLEP00000010574	ENSMLEP00000017379	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD4 molecule.	0.617
B2M	CD74	ENSMLEP00000010574	ENSMLEP00000021636	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD74 molecule.	0.513
B2M	CD8A	ENSMLEP00000010574	ENSMLEP00000004566	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD8a molecule.	0.930
B2M	CD8B	ENSMLEP00000010574	ENSMLEP00000027133	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.760
B2M	CIITA	ENSMLEP00000010574	ENSMLEP00000006369	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Class II major histocompatibility complex transactivator.	0.486
B2M	ENSMLEP00000005644	ENSMLEP00000010574	ENSMLEP00000005644	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.739
B2M	ENSMLEP00000014987	ENSMLEP00000010574	ENSMLEP00000014987	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	IGc1 domain-containing protein; Belongs to the MHC class I family.	0.818
B2M	ENSMLEP00000016260	ENSMLEP00000010574	ENSMLEP00000016260	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	MHC_I-like_Ag-recog domain-containing protein.	0.996
B2M	ENSMLEP00000017019	ENSMLEP00000010574	ENSMLEP00000017019	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	MHC_I-like_Ag-recog domain-containing protein.	0.660
B2M	ENSMLEP00000019778	ENSMLEP00000010574	ENSMLEP00000019778	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	IGc1 domain-containing protein; Belongs to the MHC class I family.	0.739
B2M	ENSMLEP00000026510	ENSMLEP00000010574	ENSMLEP00000026510	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.818
B2M	ENSMLEP00000028396	ENSMLEP00000010574	ENSMLEP00000028396	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	IGc1 domain-containing protein.	0.739
B2M	ENSMLEP00000031001	ENSMLEP00000010574	ENSMLEP00000031001	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.789
B2M	ENSMLEP00000035626	ENSMLEP00000010574	ENSMLEP00000035626	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.831
B2M	ENSMLEP00000038532	ENSMLEP00000010574	ENSMLEP00000038532	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Uncharacterized protein.	0.593
B2M	HLA-DMA	ENSMLEP00000010574	ENSMLEP00000031152	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family.	0.570
B2M	HLA-DOA	ENSMLEP00000010574	ENSMLEP00000027246	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family.	0.583
B2M	HLA-DOB	ENSMLEP00000010574	ENSMLEP00000040624	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Major histocompatibility complex, class II, DO beta.	0.593