STRINGSTRING
IKBKB IKBKB CALML6 CALML6 PTGS2 PTGS2 CLEC1B CLEC1B CEACAM8 CEACAM8 ENSMLEP00000038520 ENSMLEP00000038520 MAPK14 MAPK14 CCL22 CCL22 MALT1 MALT1 AKT3 AKT3 ENSMLEP00000036303 ENSMLEP00000036303 MDM2 MDM2 HRAS HRAS RELA RELA SRC SRC ENSMLEP00000035415 ENSMLEP00000035415 RRAD RRAD RELB RELB IL2 IL2 CBLB CBLB PRKCD PRKCD PIK3R1 PIK3R1 PLK3 PLK3 FCER1G FCER1G CALM3 CALM3 CCL17 CCL17 MAPK13 MAPK13 SYK SYK RRAS2 RRAS2 EFCAB3 EFCAB3 PIK3R3 PIK3R3 EFCAB13 EFCAB13 NRAS NRAS STAT1 STAT1 ENSMLEP00000029948 ENSMLEP00000029948 CSDE1 CSDE1 ENSMLEP00000028290 ENSMLEP00000028290 RHOA RHOA PIK3CB PIK3CB CEACAM16 CEACAM16 PPP3R1 PPP3R1 AKT1 AKT1 MAPK12 MAPK12 NFKBIA NFKBIA PIK3CD PIK3CD NFATC1 NFATC1 EGR2 EGR2 IL1B IL1B PPP3CB PPP3CB PLCG2 PLCG2 CLEC7A CLEC7A BCL10 BCL10 MAPK1 MAPK1 CHUK CHUK MAPK11 MAPK11 CASP1 CASP1 ITPR3 ITPR3 AKT2 AKT2 MAPK3 MAPK3 IRF1 IRF1 ENSMLEP00000021039 ENSMLEP00000021039 MRAS MRAS NFATC2 NFATC2 CALML4 CALML4 NLRP3 NLRP3 CLEC4G CLEC4G IL6 IL6 PIK3CA PIK3CA CALM2 CALM2 IL12B IL12B TMEM52B TMEM52B PAK1 PAK1 BCL3 BCL3 PVALEF PVALEF CLEC6A CLEC6A CEACAM7 CEACAM7 IL12A IL12A MAP3K14 MAP3K14 IKBKG IKBKG CLEC4D CLEC4D ENSMLEP00000015819 ENSMLEP00000015819 CASP8 CASP8 MAPK8 MAPK8 IL10 IL10 CLEC1A CLEC1A IKBKE IKBKE LOC105534152 LOC105534152 ENSMLEP00000013989 ENSMLEP00000013989 GEM GEM NFKB1 NFKB1 ENSMLEP00000012359 ENSMLEP00000012359 ENSMLEP00000012128 ENSMLEP00000012128 RAF1 RAF1 NFATC4 NFATC4 CALM1 CALM1 NFATC3 NFATC3 CLEC9A CLEC9A PPP3CA PPP3CA ITPR1 ITPR1 CLEC4E CLEC4E CARD9 CARD9 KRAS KRAS MAPK9 MAPK9 ERAS ERAS PTPN11 PTPN11 ENSMLEP00000006533 ENSMLEP00000006533 ARHGEF12 ARHGEF12 MAPK10 MAPK10 ITPR2 ITPR2 NFKB2 NFKB2 RRAS RRAS MAPKAPK2 MAPKAPK2 REM1 REM1 LSP1 LSP1 LOC105541944 LOC105541944 RHOC RHOC PYCARD PYCARD ENSMLEP00000004395 ENSMLEP00000004395 EGR3 EGR3 IL23A IL23A CALML3 CALML3 LOC105540811 LOC105540811 PPP3CC PPP3CC LOC105541620 LOC105541620 ENSMLEP00000002932 ENSMLEP00000002932 STAT2 STAT2 CD209 CD209 ENSMLEP00000002165 ENSMLEP00000002165 LOC105541640 LOC105541640 PIK3R2 PIK3R2 CLEC4A CLEC4A KSR1 KSR1 CYLD CYLD IRF9 IRF9 CEACAM5 CEACAM5 LOC105541165 LOC105541165
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (706 aa)
CALML6Calmodulin like 6. (181 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
CLEC1BC-type lectin domain family 1 member B. (229 aa)
CEACAM8Carcinoembryonic antigen related cell adhesion molecule 8. (349 aa)
ENSMLEP00000038520Uncharacterized protein; Belongs to the calmodulin family. (91 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
CCL22C-C motif chemokine ligand 22. (93 aa)
MALT1MALT1 paracaspase. (778 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSMLEP00000036303Ig-like domain-containing protein. (226 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
SRCTyrosine-protein kinase. (542 aa)
ENSMLEP00000035415Uncharacterized protein. (519 aa)
RRADRRAD, Ras related glycolysis inhibitor and calcium channel regulator. (248 aa)
RELBRELB proto-oncogene, NF-kB subunit. (509 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
CBLBCbl proto-oncogene B. (982 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PLK3Serine/threonine-protein kinase PLK. (626 aa)
FCER1GFc fragment of IgE receptor Ig. (112 aa)
CALM3Calmodulin 3. (149 aa)
CCL17C-C motif chemokine. (93 aa)
MAPK13Mitogen-activated protein kinase. (397 aa)
SYKTyrosine-protein kinase. (618 aa)
RRAS2RAS related 2. (176 aa)
EFCAB3EF-hand calcium binding domain 3. (488 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
EFCAB13EF-hand calcium binding domain 13. (973 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
ENSMLEP00000029948EF-hand domain-containing protein; Belongs to the calmodulin family. (73 aa)
CSDE1Cold shock domain containing E1. (844 aa)
ENSMLEP00000028290Uncharacterized protein. (441 aa)
RHOARas homolog family member A. (193 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
CEACAM16Carcinoembryonic antigen related cell adhesion molecule 16. (425 aa)
PPP3R1Uncharacterized protein. (189 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
MAPK12Mitogen-activated protein kinase. (292 aa)
NFKBIAANK_REP_REGION domain-containing protein. (305 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
NFATC1Nuclear factor of activated T cells 1. (755 aa)
EGR2Early growth response 2. (476 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1221 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
BCL10BCL10 immune signaling adaptor. (312 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MAPK11Mitogen-activated protein kinase. (224 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (404 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
IRF1Interferon regulatory factor. (325 aa)
ENSMLEP00000021039Uncharacterized protein. (370 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
NFATC2Nuclear factor of activated T cells 2. (921 aa)
CALML4Calmodulin like 4. (193 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
IL6Interleukin 6. (226 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CALM2Calmodulin 2. (149 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
TMEM52BTransmembrane protein 52B. (182 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
BCL3BCL3 transcription coactivator. (387 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
CLEC6AC-type lectin domain containing 6A. (209 aa)
CEACAM7Carcinoembryonic antigen related cell adhesion molecule 7. (262 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (396 aa)
CLEC4DC-type lectin domain family 4 member D. (215 aa)
ENSMLEP00000015819Uncharacterized protein. (208 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (479 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL10Interleukin 10. (178 aa)
CLEC1AC-type lectin domain family 1 member A. (280 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (697 aa)
LOC105534152Uncharacterized protein; Belongs to the peptidase C14A family. (352 aa)
ENSMLEP00000013989IGv domain-containing protein. (155 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
ENSMLEP00000012359Uncharacterized protein. (344 aa)
ENSMLEP00000012128Uncharacterized protein. (234 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
NFATC4Nuclear factor of activated T cells 4. (914 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
NFATC3Nuclear factor of activated T cells 3. (1068 aa)
CLEC9AC-type lectin domain containing 9A. (241 aa)
PPP3CASerine/threonine-protein phosphatase. (501 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2731 aa)
CLEC4EC-type lectin domain family 4 member E. (219 aa)
CARD9Caspase recruitment domain family member 9. (992 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAPK9Mitogen-activated protein kinase. (395 aa)
ERASES cell expressed Ras. (233 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (656 aa)
ENSMLEP00000006533Uncharacterized protein. (189 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
MAPK10Mitogen-activated protein kinase. (477 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2663 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
RRASRAS related. (218 aa)
MAPKAPK2MAPK activated protein kinase 2. (362 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
LSP1Lymphocyte specific protein 1. (430 aa)
LOC105541944IGv domain-containing protein. (252 aa)
RHOCRas homolog family member C. (193 aa)
PYCARDPYD and CARD domain containing. (195 aa)
ENSMLEP00000004395Uncharacterized protein. (178 aa)
EGR3Early growth response 3. (387 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
LOC105540811Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
LOC105541620Uncharacterized protein. (412 aa)
ENSMLEP00000002932Ig-like domain-containing protein. (318 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
CD209CD209 molecule. (381 aa)
ENSMLEP00000002165Uncharacterized protein; Belongs to the calmodulin family. (95 aa)
LOC105541640Uncharacterized protein. (526 aa)
PIK3R2Uncharacterized protein. (587 aa)
CLEC4AC-type lectin domain family 4 member A. (237 aa)
KSR1Kinase suppressor of ras 1. (867 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
IRF9Interferon regulatory factor 9. (392 aa)
CEACAM5Uncharacterized protein. (346 aa)
LOC105541165Uncharacterized protein. (447 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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