STRINGSTRING
PPP3CA PPP3CA IFNGR1 IFNGR1 VAV2 VAV2 VAV1 VAV1 RAF1 RAF1 ENSMLEP00000012128 ENSMLEP00000012128 ENSMLEP00000012226 ENSMLEP00000012226 ENSMLEP00000012301 ENSMLEP00000012301 LOC105552669 LOC105552669 TYROBP TYROBP TNFSF10 TNFSF10 PTK2B PTK2B ENSMLEP00000014409 ENSMLEP00000014409 SHC4 SHC4 PTPN6 PTPN6 LOC105549769 LOC105549769 ENSMLEP00000024805 ENSMLEP00000024805 LCK LCK MAP2K2 MAP2K2 FYN FYN LOC105528777 LOC105528777 GRB2 GRB2 LCP2 LCP2 ICAM2 ICAM2 NFATC1 NFATC1 ITGB2 ITGB2 ARAF ARAF SH2D1B SH2D1B LOC105551610 LOC105551610 PIK3CD PIK3CD LOC105537894 LOC105537894 CSF2 CSF2 FASLG FASLG IFNGR2 IFNGR2 ENSMLEP00000027485 ENSMLEP00000027485 KLRK1 KLRK1 PPP3R1 PPP3R1 KLRG1 KLRG1 PIK3CB PIK3CB KLRD1 KLRD1 ENSMLEP00000028290 ENSMLEP00000028290 SH2D1A SH2D1A PLCG1 PLCG1 CSDE1 CSDE1 NRAS NRAS TREML4 TREML4 PIK3R3 PIK3R3 FAS FAS ENSMLEP00000031588 ENSMLEP00000031588 ENSMLEP00000031969 ENSMLEP00000031969 SYK SYK LOC105546382 LOC105546382 ENSMLEP00000033059 ENSMLEP00000033059 FCER1G FCER1G LOC105545697 LOC105545697 PIK3R1 PIK3R1 BRAF BRAF LOC105551010 LOC105551010 ENSMLEP00000035415 ENSMLEP00000035415 LAT LAT SHC1 SHC1 HRAS HRAS KLRC1 KLRC1 SHC2 SHC2 SRMS SRMS SH3BP2 SH3BP2 LOC105545698 LOC105545698 ULBP1 ULBP1 CD247 CD247 NCR1 NCR1 RAC3 RAC3 IFNAR1 IFNAR1 CEP152 CEP152 RAET1G RAET1G RAC1 RAC1 ENSMLEP00000001022 ENSMLEP00000001022 SHC3 SHC3 PIK3R2 PIK3R2 TNFRSF10B TNFRSF10B ENSMLEP00000003171 ENSMLEP00000003171 CD244 CD244 PPP3CC PPP3CC TNFRSF10A TNFRSF10A ENSMLEP00000018490 ENSMLEP00000018490 RAC2 RAC2 BID BID PAK1 PAK1 IFNAR2 IFNAR2 PIK3CA PIK3CA MAP2K1 MAP2K1 GZMB GZMB CD48 CD48 NFATC2 NFATC2 ICAM1 ICAM1 PRKCA PRKCA MAPK3 MAPK3 SOS1 SOS1 IFNG IFNG SOS2 SOS2 ITGAL ITGAL LOC105551614 LOC105551614 ENSMLEP00000023116 ENSMLEP00000023116 ENSMLEP00000023401 ENSMLEP00000023401 LOC105551611 LOC105551611 MAPK1 MAPK1 PLCG2 PLCG2 PPP3CB PPP3CB PRKCB PRKCB PRKCG PRKCG HCST HCST GZMH GZMH PTPN11 PTPN11 KIR2DL4 KIR2DL4 ERAS ERAS MICB MICB NCR2 NCR2 LOC105542014 LOC105542014 RAET1E RAET1E PRF1 PRF1 ZAP70 ZAP70 KRAS KRAS LOC105551601 LOC105551601 CASP3 CASP3 VAV3 VAV3 NCR3 NCR3 PTK6 PTK6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP3CASerine/threonine-protein phosphatase. (501 aa)
IFNGR1Interferon gamma receptor 1. (488 aa)
VAV2Vav guanine nucleotide exchange factor 2. (787 aa)
VAV1Vav guanine nucleotide exchange factor 1. (766 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
ENSMLEP00000012128Uncharacterized protein. (234 aa)
ENSMLEP00000012226Uncharacterized protein. (198 aa)
ENSMLEP00000012301Protein kinase domain-containing protein. (294 aa)
LOC105552669Uncharacterized protein; Belongs to the peptidase C14A family. (215 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (144 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (281 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ENSMLEP00000014409Ig-like domain-containing protein. (328 aa)
SHC4SHC adaptor protein 4. (630 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
LOC105549769Uncharacterized protein. (182 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
LCKTyrosine-protein kinase. (536 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (389 aa)
FYNTyrosine-protein kinase. (537 aa)
LOC105528777MHC_I-like_Ag-recog domain-containing protein. (245 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
ICAM2Intercellular adhesion molecule 2. (275 aa)
NFATC1Nuclear factor of activated T cells 1. (755 aa)
ITGB2Integrin beta. (769 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (604 aa)
SH2D1BSH2 domain containing 1B. (132 aa)
LOC105551610Uncharacterized protein. (452 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LOC105537894Uncharacterized protein. (192 aa)
CSF2Colony stimulating factor 2. (144 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
IFNGR2Interferon gamma receptor 2. (408 aa)
ENSMLEP00000027485PID domain-containing protein. (488 aa)
KLRK1Killer cell lectin like receptor K1. (216 aa)
PPP3R1Uncharacterized protein. (189 aa)
KLRG1Killer cell lectin like receptor G1. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
KLRD1Killer cell lectin like receptor D1. (179 aa)
ENSMLEP00000028290Uncharacterized protein. (441 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (125 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1276 aa)
CSDE1Cold shock domain containing E1. (844 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
TREML4Triggering receptor expressed on myeloid cells like 4. (138 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
FASFas cell surface death receptor. (331 aa)
ENSMLEP00000031588Ig-like domain-containing protein. (117 aa)
ENSMLEP00000031969MHC_I-like_Ag-recog domain-containing protein. (243 aa)
SYKTyrosine-protein kinase. (618 aa)
LOC105546382Uncharacterized protein. (298 aa)
ENSMLEP00000033059Ig-like domain-containing protein. (153 aa)
FCER1GFc fragment of IgE receptor Ig. (112 aa)
LOC105545697MHC_I-like_Ag-recog domain-containing protein. (253 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
LOC105551010Ig-like domain-containing protein. (336 aa)
ENSMLEP00000035415Uncharacterized protein. (519 aa)
LATLinker for activation of T cells. (235 aa)
SHC1SHC adaptor protein 1. (584 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
KLRC1C-type lectin domain-containing protein. (233 aa)
SHC2Uncharacterized protein. (483 aa)
SRMSTyrosine-protein kinase. (489 aa)
SH3BP2SH3 domain binding protein 2. (589 aa)
LOC105545698MHC_I-like_Ag-recog domain-containing protein. (249 aa)
ULBP1UL16 binding protein 1. (255 aa)
CD247CD247 molecule. (164 aa)
NCR1Natural cytotoxicity triggering receptor 1. (195 aa)
RAC3Rac family small GTPase 3. (212 aa)
IFNAR1Uncharacterized protein. (332 aa)
CEP152Centrosomal protein 152. (1709 aa)
RAET1GMHC_I-like_Ag-recog domain-containing protein. (336 aa)
RAC1Uncharacterized protein. (280 aa)
ENSMLEP00000001022Uncharacterized protein. (189 aa)
SHC3SHC adaptor protein 3. (444 aa)
PIK3R2Uncharacterized protein. (587 aa)
TNFRSF10BTNF receptor superfamily member 10b. (445 aa)
ENSMLEP00000003171C-type lectin domain-containing protein. (231 aa)
CD244CD244 molecule. (370 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
TNFRSF10ATNF receptor superfamily member 10a. (433 aa)
ENSMLEP00000018490Uncharacterized protein. (145 aa)
RAC2Rac family small GTPase 2. (192 aa)
BIDBH3 interacting domain death agonist. (244 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
IFNAR2Uncharacterized protein. (516 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (247 aa)
CD48CD48 molecule. (294 aa)
NFATC2Nuclear factor of activated T cells 2. (921 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1299 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1317 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1148 aa)
LOC105551614Uncharacterized protein. (442 aa)
ENSMLEP00000023116MHC_I-like_Ag-recog domain-containing protein. (191 aa)
ENSMLEP00000023401MHC_I-like_Ag-recog domain-containing protein. (230 aa)
LOC105551611Uncharacterized protein. (447 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1221 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
PRKCGProtein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (558 aa)
HCSTHematopoietic cell signal transducer. (91 aa)
GZMHGranzyme H; Belongs to the peptidase S1 family. (229 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (656 aa)
KIR2DL4Uncharacterized protein. (369 aa)
ERASES cell expressed Ras. (233 aa)
MICBIg-like domain-containing protein. (334 aa)
NCR2Natural cytotoxicity triggering receptor 2. (294 aa)
LOC105542014C-type lectin domain-containing protein. (285 aa)
RAET1EMHC_I_2 domain-containing protein. (263 aa)
PRF1Perforin 1. (555 aa)
ZAP70Tyrosine-protein kinase. (507 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
LOC105551601Uncharacterized protein. (360 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
NCR3Natural cytotoxicity triggering receptor 3. (180 aa)
PTK6Tyrosine-protein kinase. (451 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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