STRINGSTRING
FOS FOS ZAP70 ZAP70 PIK3R2 PIK3R2 ICOS ICOS PPP3CC PPP3CC PAK5 PAK5 CD3G CD3G PAK6 PAK6 CD8A CD8A RHOC RHOC MAPK10 MAPK10 ERAS ERAS PAK2 PAK2 MAPK9 MAPK9 LOC105530991 LOC105530991 KRAS KRAS VAV3 VAV3 NCK1 NCK1 PTK6 PTK6 PPP3CA PPP3CA VAV2 VAV2 VAV1 VAV1 NFATC3 NFATC3 RAF1 RAF1 IL5 IL5 PDPK1 PDPK1 ENSMLEP00000012170 ENSMLEP00000012170 NFKB1 NFKB1 CD3D CD3D PTPN6 PTPN6 PTPRC PTPRC LCK LCK MAP2K2 MAP2K2 IL10 IL10 PRKCQ PRKCQ FYN FYN MAPK8 MAPK8 MAP2K7 MAP2K7 IKBKG IKBKG MAP3K14 MAP3K14 CD4 CD4 IKBKB IKBKB GRB2 GRB2 ENSMLEP00000018399 ENSMLEP00000018399 ENSMLEP00000018677 ENSMLEP00000018677 PAK1 PAK1 PIK3CA PIK3CA MAP2K1 MAP2K1 NFATC2 NFATC2 MAPK3 MAPK3 SOS1 SOS1 AKT2 AKT2 IFNG IFNG SOS2 SOS2 MAPK11 MAPK11 CHUK CHUK MAPK1 MAPK1 BCL10 BCL10 PPP3CB PPP3CB GSK3B GSK3B ENSMLEP00000024805 ENSMLEP00000024805 LCP2 LCP2 NFATC1 NFATC1 PIK3CD PIK3CD NFKBIA NFKBIA CDK4 CDK4 CSF2 CSF2 CD28 CD28 CTLA4 CTLA4 CD8B CD8B MAPK12 MAPK12 NFKBIB NFKBIB TEC TEC GRAP2 GRAP2 AKT1 AKT1 PPP3R1 PPP3R1 PIK3CB PIK3CB RHOA RHOA PLCG1 PLCG1 CSDE1 CSDE1 NFKBIE NFKBIE IL4 IL4 NRAS NRAS MAP3K7 MAP3K7 PIK3R3 PIK3R3 TRAC TRAC PAK3 PAK3 MAPK13 MAPK13 PDCD1 PDCD1 PIK3R1 PIK3R1 CBLB CBLB DLG1 DLG1 LOC105542528 LOC105542528 IL2 IL2 ITK ITK LAT LAT PAK4 PAK4 RELA RELA CDC42 CDC42 HRAS HRAS CD3E CD3E AKT3 AKT3 SRMS SRMS MALT1 MALT1 CD40LG CD40LG MAP3K8 MAP3K8 MAPK14 MAPK14 NCK2 NCK2 CARD11 CARD11 RASGRP1 RASGRP1 CD247 CD247
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ZAP70Tyrosine-protein kinase. (507 aa)
PIK3R2Uncharacterized protein. (587 aa)
ICOSInducible T cell costimulator. (199 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
CD3GCD3g molecule. (166 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
CD8ACD8a molecule. (235 aa)
RHOCRas homolog family member C. (193 aa)
MAPK10Mitogen-activated protein kinase. (477 aa)
ERASES cell expressed Ras. (233 aa)
PAK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (477 aa)
MAPK9Mitogen-activated protein kinase. (395 aa)
LOC105530991Uncharacterized protein. (185 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
NCK1Cytoplasmic protein. (377 aa)
PTK6Tyrosine-protein kinase. (451 aa)
PPP3CASerine/threonine-protein phosphatase. (501 aa)
VAV2Vav guanine nucleotide exchange factor 2. (787 aa)
VAV1Vav guanine nucleotide exchange factor 1. (766 aa)
NFATC3Nuclear factor of activated T cells 3. (1068 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (529 aa)
ENSMLEP00000012170Ig-like domain-containing protein. (147 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CD3DCD3d molecule. (171 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1241 aa)
LCKTyrosine-protein kinase. (536 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (389 aa)
IL10Interleukin 10. (178 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
FYNTyrosine-protein kinase. (537 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (442 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (396 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
CD4CD4 molecule. (458 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (706 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ENSMLEP00000018399Uncharacterized protein. (153 aa)
ENSMLEP00000018677Uncharacterized protein. (185 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NFATC2Nuclear factor of activated T cells 2. (921 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1299 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1317 aa)
MAPK11Mitogen-activated protein kinase. (224 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
BCL10BCL10 immune signaling adaptor. (312 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
NFATC1Nuclear factor of activated T cells 1. (755 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
NFKBIAANK_REP_REGION domain-containing protein. (305 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CSF2Colony stimulating factor 2. (144 aa)
CD28CD28 molecule. (220 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
CD8BIg-like domain-containing protein. (243 aa)
MAPK12Mitogen-activated protein kinase. (292 aa)
NFKBIBNFKB inhibitor beta. (286 aa)
TECTyrosine-protein kinase. (630 aa)
GRAP2GRB2 related adaptor protein 2. (330 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
PPP3R1Uncharacterized protein. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
RHOARas homolog family member A. (193 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1276 aa)
CSDE1Cold shock domain containing E1. (844 aa)
NFKBIENFKB inhibitor epsilon. (489 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
TRACT cell receptor alpha constant. (110 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
MAPK13Mitogen-activated protein kinase. (397 aa)
PDCD1Programmed cell death 1. (288 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CBLBCbl proto-oncogene B. (982 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
LOC105542528Uncharacterized protein. (173 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
ITKTyrosine-protein kinase. (620 aa)
LATLinker for activation of T cells. (235 aa)
PAK4Non-specific serine/threonine protein kinase. (349 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
CDC42Uncharacterized protein. (191 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CD3ECD3e molecule. (198 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SRMSTyrosine-protein kinase. (489 aa)
MALT1MALT1 paracaspase. (778 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
NCK2Cytoplasmic protein. (380 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
RASGRP1RAS guanyl releasing protein 1. (832 aa)
CD247CD247 molecule. (164 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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