STRINGSTRING
MAP2K1 MAP2K1 ENSMLEP00000019993 ENSMLEP00000019993 PRKCA PRKCA MAPK3 MAPK3 ENSMLEP00000021624 ENSMLEP00000021624 AKT2 AKT2 PLA2G4C PLA2G4C MAPK1 MAPK1 MYO10 MYO10 PLCG2 PLCG2 PLD1 PLD1 NCF1 NCF1 PRKCB PRKCB PRKCG PRKCG ENSMLEP00000024805 ENSMLEP00000024805 SPHK1 SPHK1 AMPH AMPH PIK3CD PIK3CD PLD2 PLD2 HCK HCK INPP5D INPP5D ARPC4 ARPC4 AKT1 AKT1 LOC105539503 LOC105539503 PIK3CB PIK3CB PLCG1 PLCG1 JMJD7 JMJD7 GAB2 GAB2 PLA2G4B PLA2G4B PIK3R3 PIK3R3 FCGR2A FCGR2A ENSMLEP00000031455 ENSMLEP00000031455 ENSMLEP00000031588 ENSMLEP00000031588 WASF3 WASF3 SYK SYK LIMK2 LIMK2 SPHK2 SPHK2 ENSMLEP00000033059 ENSMLEP00000033059 ENSMLEP00000033209 ENSMLEP00000033209 PRKCE PRKCE DNM2 DNM2 PTPRC PTPRC ARPC1A ARPC1A PIP5K1C PIP5K1C PIK3R1 PIK3R1 PLA2G4A PLA2G4A CCDC125 CCDC125 GAB4 GAB4 ENSMLEP00000014001 ENSMLEP00000014001 ASAP1 ASAP1 PIP5K1B PIP5K1B GSN GSN LOC105550771 LOC105550771 ASAP3 ASAP3 BIN1 BIN1 RAF1 RAF1 VAV1 VAV1 PLPP1 PLPP1 FCGR1A FCGR1A VAV2 VAV2 VAV3 VAV3 RPS6KB2 RPS6KB2 PLPP3 PLPP3 LOC105530991 LOC105530991 ENSMLEP00000007391 ENSMLEP00000007391 RPS6KB1 RPS6KB1 LOC105545893 LOC105545893 CRK CRK WASF1 WASF1 ARF6 ARF6 ENSMLEP00000003812 ENSMLEP00000003812 ARPC2 ARPC2 FCGR2B FCGR2B PLA2G4F PLA2G4F INPPL1 INPPL1 PLA2G4E PLA2G4E PIK3R2 PIK3R2 LYN LYN DOCK1 DOCK1 CFL2 CFL2 ARPC5 ARPC5 LOC105528457 LOC105528457 BOLA1 BOLA1 ARPC5L ARPC5L PIP5K1A PIP5K1A LOC105528504 LOC105528504 WAS WAS LOC105546331 LOC105546331 ENSMLEP00000017110 ENSMLEP00000017110 PLA2G4D PLA2G4D LIMK1 LIMK1 PLPP2 PLPP2 AKT3 AKT3 CDC42 CDC42 ARPC3 ARPC3 LAT LAT LOC105551010 LOC105551010 WASF2 WASF2 VASP VASP LOC105542528 LOC105542528 ENSMLEP00000034516 ENSMLEP00000034516 PLA2G6 PLA2G6 PRKCD PRKCD GOLGA2 GOLGA2 ENSMLEP00000018145 ENSMLEP00000018145 ASAP2 ASAP2 ENSMLEP00000018399 ENSMLEP00000018399 ENSMLEP00000018490 ENSMLEP00000018490 RAC2 RAC2 ENSMLEP00000018677 ENSMLEP00000018677 PAK1 PAK1 SCIN SCIN CRKL CRKL PIK3CA PIK3CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ENSMLEP00000019993ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (135 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
ENSMLEP00000021624PIPK domain-containing protein. (457 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PLA2G4CPhospholipase A2 group IVC. (469 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2014 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1221 aa)
PLD1Phospholipase. (1074 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
PRKCGProtein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (558 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
SPHK1Sphingosine kinase 1. (470 aa)
AMPHAmphiphysin. (677 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PLD2Phospholipase. (933 aa)
HCKTyrosine-protein kinase. (520 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1180 aa)
ARPC4Actin related protein 2/3 complex subunit 4. (136 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
LOC105539503WD_REPEATS_REGION domain-containing protein. (336 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1276 aa)
JMJD7Jumonji domain containing 7. (316 aa)
GAB2GRB2 associated binding protein 2. (667 aa)
PLA2G4BPhospholipase A2. (781 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
FCGR2AUncharacterized protein. (276 aa)
ENSMLEP00000031455PIPK domain-containing protein. (487 aa)
ENSMLEP00000031588Ig-like domain-containing protein. (117 aa)
WASF3WASP family member 3. (502 aa)
SYKTyrosine-protein kinase. (618 aa)
LIMK2LIM domain kinase 2. (638 aa)
SPHK2Sphingosine kinase 2. (663 aa)
ENSMLEP00000033059Ig-like domain-containing protein. (153 aa)
ENSMLEP00000033209ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (209 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (810 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1241 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (365 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (669 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PLA2G4APhospholipase A2. (749 aa)
CCDC125Coiled-coil domain containing 125. (312 aa)
GAB4GRB2 associated binding protein family member 4. (555 aa)
ENSMLEP00000014001Uncharacterized protein. (151 aa)
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. (1098 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (575 aa)
GSNGelsolin. (787 aa)
LOC105550771Uncharacterized protein. (504 aa)
ASAP3ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (769 aa)
BIN1Bridging integrator 1. (593 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
VAV1Vav guanine nucleotide exchange factor 1. (766 aa)
PLPP1Phospholipid phosphatase 1. (313 aa)
FCGR1AUncharacterized protein. (362 aa)
VAV2Vav guanine nucleotide exchange factor 2. (787 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
PLPP3acidPPc domain-containing protein. (311 aa)
LOC105530991Uncharacterized protein. (185 aa)
ENSMLEP00000007391Uncharacterized protein. (664 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
LOC105545893ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (158 aa)
CRKCRK proto-oncogene, adaptor protein. (245 aa)
WASF1WASP family member 1. (559 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
ENSMLEP00000003812ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (158 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (306 aa)
FCGR2BUncharacterized protein. (313 aa)
PLA2G4FPhospholipase A2. (849 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1235 aa)
PLA2G4EPhospholipase A2. (869 aa)
PIK3R2Uncharacterized protein. (587 aa)
LYNTyrosine-protein kinase. (470 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1824 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (154 aa)
LOC105528457ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (194 aa)
BOLA1BolA family member 1; Belongs to the BolA/IbaG family. (137 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (125 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (493 aa)
LOC105528504Uncharacterized protein. (474 aa)
WASWASP actin nucleation promoting factor. (503 aa)
LOC105546331Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (161 aa)
ENSMLEP00000017110Uncharacterized protein. (475 aa)
PLA2G4DPhospholipase A2. (817 aa)
LIMK1LIM domain kinase 1. (633 aa)
PLPP2Phospholipid phosphatase 2. (285 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CDC42Uncharacterized protein. (191 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (158 aa)
LATLinker for activation of T cells. (235 aa)
LOC105551010Ig-like domain-containing protein. (336 aa)
WASF2WASP family member 2. (498 aa)
VASPVasodilator stimulated phosphoprotein. (432 aa)
LOC105542528Uncharacterized protein. (173 aa)
ENSMLEP00000034516WD_REPEATS_REGION domain-containing protein. (140 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
GOLGA2Golgin A2. (1005 aa)
ENSMLEP00000018145Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (126 aa)
ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2. (964 aa)
ENSMLEP00000018399Uncharacterized protein. (153 aa)
ENSMLEP00000018490Uncharacterized protein. (145 aa)
RAC2Rac family small GTPase 2. (192 aa)
ENSMLEP00000018677Uncharacterized protein. (185 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
SCINScinderin. (715 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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