STRINGSTRING
PIK3CD PIK3CD CSF2 CSF2 MAPK12 MAPK12 FADD FADD AKT1 AKT1 CEACAM16 CEACAM16 PIK3CB PIK3CB TAB3 TAB3 CREB5 CREB5 MAP3K7 MAP3K7 TAB2 TAB2 PIK3R3 PIK3R3 FAS FAS CXCL10 CXCL10 FOS FOS MAPK13 MAPK13 IL15 IL15 MAP2K4 MAP2K4 TRAF5 TRAF5 PIK3R1 PIK3R1 CXCL5 CXCL5 TNFRSF1A TNFRSF1A BIRC3 BIRC3 MMP9 MMP9 RELA RELA CASP7 CASP7 AKT3 AKT3 TRAF2 TRAF2 ENSMLEP00000037519 ENSMLEP00000037519 MAP3K8 MAP3K8 DNM1L DNM1L MMP3 MMP3 CREB3L2 CREB3L2 TNFRSF1B TNFRSF1B MAPK14 MAPK14 RFWD3 RFWD3 RIPK3 RIPK3 VEGFD VEGFD SELE SELE LOC105531126 LOC105531126 PTGS2 PTGS2 RPS6KA5 RPS6KA5 MAP3K5 MAP3K5 VEGFC VEGFC CREB3L1 CREB3L1 CXCL6 CXCL6 MMP14 MMP14 JUNB JUNB BAG4 BAG4 PIK3R2 PIK3R2 LOC105531130 LOC105531130 CREB3 CREB3 EDN1 EDN1 CXCL2 CXCL2 ATF4 ATF4 TNFAIP3 TNFAIP3 RIPK1 RIPK1 CREB3L3 CREB3L3 MAPK10 MAPK10 CX3CL1 CX3CL1 MAPK9 MAPK9 MLKL MLKL IL18R1 IL18R1 CASP3 CASP3 LIF LIF CFLAR CFLAR ENSMLEP00000011508 ENSMLEP00000011508 MAP2K3 MAP2K3 RPS6KA4 RPS6KA4 DAB2IP DAB2IP LOC105552669 LOC105552669 NFKB1 NFKB1 CREB3L4 CREB3L4 MAP2K6 MAP2K6 MMP10 MMP10 MAPK8 MAPK8 CASP8 CASP8 MAP2K7 MAP2K7 IKBKG IKBKG MAP3K14 MAP3K14 PGAM5 PGAM5 IKBKB IKBKB TRAF3 TRAF3 CCL5 CCL5 BCL3 BCL3 ATF6B ATF6B CCL2 CCL2 CREB1 CREB1 PIK3CA PIK3CA IL6 IL6 MAP2K1 MAP2K1 ICAM1 ICAM1 TRADD TRADD IRF1 IRF1 MAPK3 MAPK3 JAG1 JAG1 AKT2 AKT2 CCL20 CCL20 BIRC2 BIRC2 ATF2 ATF2 ITCH ITCH MAPK11 MAPK11 CHUK CHUK CASP10 CASP10 MAPK1 MAPK1 TRAF1 TRAF1 LTA LTA TAB1 TAB1 CSF1 CSF1 IL1B IL1B ENSMLEP00000024805 ENSMLEP00000024805 NOD2 NOD2 CXCL1 CXCL1 CCDC88B CCDC88B VCAM1 VCAM1 NFKBIA NFKBIA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CSF2Colony stimulating factor 2. (144 aa)
MAPK12Mitogen-activated protein kinase. (292 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
CEACAM16Carcinoembryonic antigen related cell adhesion molecule 16. (425 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
FASFas cell surface death receptor. (331 aa)
CXCL10C-X-C motif chemokine. (98 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK13Mitogen-activated protein kinase. (397 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (373 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CXCL5C-X-C motif chemokine. (114 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (336 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
ENSMLEP00000037519Uncharacterized protein. (87 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (734 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
TNFRSF1BTNF receptor superfamily member 1B. (462 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
RFWD3Ring finger and WD repeat domain 3. (774 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
SELESelectin E. (610 aa)
LOC105531126C-X-C motif chemokine. (107 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
RPS6KA5Ribosomal protein S6 kinase. (801 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1306 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (402 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (466 aa)
CXCL6C-X-C motif chemokine. (114 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
BAG4BCL2 associated athanogene 4. (367 aa)
PIK3R2Uncharacterized protein. (587 aa)
LOC105531130C-X-C motif chemokine. (154 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
EDN1Endothelin 1. (211 aa)
CXCL2C-X-C motif chemokine. (107 aa)
ATF4Activating transcription factor 4. (351 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (620 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (321 aa)
MAPK10Mitogen-activated protein kinase. (477 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (402 aa)
MAPK9Mitogen-activated protein kinase. (395 aa)
MLKLMixed lineage kinase domain like pseudokinase. (470 aa)
IL18R1Interleukin 18 receptor 1. (540 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
ENSMLEP00000011508C-X-C motif chemokine. (86 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
RPS6KA4Ribosomal protein S6 kinase. (772 aa)
DAB2IPDAB2 interacting protein. (1153 aa)
LOC105552669Uncharacterized protein; Belongs to the peptidase C14A family. (215 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (422 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa)
MMP10Matrix metallopeptidase 10. (476 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (479 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (442 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (396 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
PGAM5Uncharacterized protein. (140 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (706 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CCL5C-C motif chemokine. (91 aa)
BCL3BCL3 transcription coactivator. (387 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
CCL2C-C motif chemokine. (99 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IL6Interleukin 6. (226 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
TRADDTNFRSF1A associated via death domain. (308 aa)
IRF1Interferon regulatory factor. (325 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CCL20C-C motif chemokine. (96 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
MAPK11Mitogen-activated protein kinase. (224 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (519 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
TRAF1TNF receptor-associated factor. (416 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1012 aa)
CXCL1C-X-C motif chemokine. (107 aa)
CCDC88BCoiled-coil domain containing 88B. (1366 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
NFKBIAANK_REP_REGION domain-containing protein. (305 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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