STRINGSTRING
CACNA1F CACNA1F CREB3L1 CREB3L1 CHRNA3 CHRNA3 SLC5A7 SLC5A7 KCNQ1 KCNQ1 PLCB3 PLCB3 CREB3L2 CREB3L2 ADCY6 ADCY6 KCNJ14 KCNJ14 GNG13 GNG13 SRMS SRMS AKT3 AKT3 CHRNA7 CHRNA7 HRAS HRAS GNG8 GNG8 CACNA1S CACNA1S GNAI1 GNAI1 PIK3R1 PIK3R1 GNGT1 GNGT1 PRKACB PRKACB FOS FOS CACNA1B CACNA1B CACNA1A CACNA1A CAMK2A CAMK2A GNG4 GNG4 PIK3R3 PIK3R3 ARSI ARSI NRAS NRAS GNG3 GNG3 CREB5 CREB5 GNG5 GNG5 CSDE1 CSDE1 KCNQ2 KCNQ2 GNG12 GNG12 GNAO1 GNAO1 CHRNB4 CHRNB4 ENSMLEP00000028401 ENSMLEP00000028401 PIK3CB PIK3CB AKT1 AKT1 ADCY3 ADCY3 CACNA1C CACNA1C GNAI3 GNAI3 PIK3CD PIK3CD GNGT2 GNGT2 ADCY5 ADCY5 KCNJ3 KCNJ3 ENSMLEP00000024805 ENSMLEP00000024805 ENSMLEP00000024790 ENSMLEP00000024790 PRKCG PRKCG CHAT CHAT PRKCB PRKCB ADCY1 ADCY1 GNB2 GNB2 MAPK1 MAPK1 PLCB2 PLCB2 CHRNA4 CHRNA4 GNB5 GNB5 ITPR3 ITPR3 KCNQ5 KCNQ5 CAMK4 CAMK4 AKT2 AKT2 PIK3R6 PIK3R6 MAPK3 MAPK3 PRKCA PRKCA PRKACA PRKACA GNB1 GNB1 MAP2K1 MAP2K1 CACNA1D CACNA1D PIK3CA PIK3CA CREB1 CREB1 ADCY2 ADCY2 CHRNB2 CHRNB2 KCNQ4 KCNQ4 FYN FYN CREB3L4 CREB3L4 JAK2 JAK2 PIK3CG PIK3CG PTK6 PTK6 ITPR1 ITPR1 GNAQ GNAQ PLCB4 PLCB4 PIK3R5 PIK3R5 LOC105550079 LOC105550079 GNG2 GNG2 SLC18A3 SLC18A3 KRAS KRAS CAMK2G CAMK2G CAMK2B CAMK2B KCNJ2 KCNJ2 PLCB1 PLCB1 ENSMLEP00000007417 ENSMLEP00000007417 CHRNA6 CHRNA6 ERAS ERAS KCNJ4 KCNJ4 CREB3L3 CREB3L3 GNB3 GNB3 ITPR2 ITPR2 GNAI2 GNAI2 BCL2 BCL2 ATF4 ATF4 ADCY8 ADCY8 CHRM1 CHRM1 ADCY7 ADCY7 ADCY9 ADCY9 KCNJ12 KCNJ12 GNB4 GNB4 ACHE ACHE ADCY4 ADCY4 CREB3 CREB3 KCNQ3 KCNQ3 CHRM4 CHRM4 ENSMLEP00000001951 ENSMLEP00000001951 PIK3R2 PIK3R2 KCNJ6 KCNJ6 CHRM2 CHRM2 GNA11 GNA11 CAMK2D CAMK2D CHRM5 CHRM5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (466 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (500 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (592 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
KCNJ14Potassium voltage-gated channel subfamily J member 14. (436 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
SRMSTyrosine-protein kinase. (489 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CHRNA7Uncharacterized protein. (473 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1846 aa)
GNAI1G protein subunit alpha i1. (314 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CACNA1BCalcium voltage-gated channel subunit alpha1 B. (2001 aa)
CACNA1ACalcium voltage-gated channel subunit alpha1 A. (1985 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
ARSIArylsulfatase family member I. (568 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CSDE1Cold shock domain containing E1. (844 aa)
KCNQ2Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. (932 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNAO1G protein subunit alpha o1. (354 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (442 aa)
ENSMLEP00000028401Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (65 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2169 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
ENSMLEP00000024790Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (294 aa)
PRKCGProtein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (558 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (631 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
GNB2G protein subunit beta 2. (340 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (600 aa)
GNB5G protein subunit beta 5. (357 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
KCNQ5Potassium voltage-gated channel subfamily Q member 5. (878 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
GNB1G protein subunit beta 1. (340 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (901 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (502 aa)
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (608 aa)
FYNTyrosine-protein kinase. (537 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (422 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1082 aa)
PTK6Tyrosine-protein kinase. (451 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2731 aa)
GNAQG protein subunit alpha q. (313 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (881 aa)
LOC105550079Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
SLC18A3Solute carrier family 18 member A3. (518 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (546 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (689 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
ENSMLEP00000007417Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
ERASES cell expressed Ras. (233 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (445 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (321 aa)
GNB3G protein subunit beta 3. (340 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2663 aa)
GNAI2G protein subunit alpha i2. (352 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ATF4Activating transcription factor 4. (351 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
KCNJ12Uncharacterized protein. (433 aa)
GNB4G protein subunit beta 4. (340 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (631 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
KCNQ3Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family. (752 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (479 aa)
ENSMLEP00000001951Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (60 aa)
PIK3R2Uncharacterized protein. (587 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
GNA11G protein subunit alpha 11. (307 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (441 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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