STRINGSTRING
PLA2G4D PLA2G4D HTR6 HTR6 TPH2 TPH2 DDC DDC MAOA MAOA KCNJ6 KCNJ6 GABRB2 GABRB2 SLC6A4 SLC6A4 PLA2G4E PLA2G4E ENSMLEP00000001951 ENSMLEP00000001951 PLA2G4F PLA2G4F LOC105534699 LOC105534699 HTR1B HTR1B ALOX12 ALOX12 GNB4 GNB4 GNAS GNAS HTR2B HTR2B PTGS1 PTGS1 HTR1D HTR1D GNAI2 GNAI2 ITPR2 ITPR2 GNB3 GNB3 ERAS ERAS ENSMLEP00000007417 ENSMLEP00000007417 PLCB1 PLCB1 HTR1F HTR1F HTR2A HTR2A KRAS KRAS HTR1A HTR1A GNG2 GNG2 CASP3 CASP3 LOC105550079 LOC105550079 CYP2J2 CYP2J2 PLCB4 PLCB4 GNAQ GNAQ ITPR1 ITPR1 CYP2C18 CYP2C18 RAF1 RAF1 CYP4X1 CYP4X1 ENSMLEP00000012301 ENSMLEP00000012301 LOC105552669 LOC105552669 HTR7 HTR7 CYP4Z1 CYP4Z1 PLA2G4A PLA2G4A GABRB3 GABRB3 KCND2 KCND2 HTR3C HTR3C TPH1 TPH1 HTR4 HTR4 KCNJ9 KCNJ9 SLC18A2 SLC18A2 CYP2W1 CYP2W1 ALOX15B ALOX15B CACNA1D CACNA1D MAP2K1 MAP2K1 HTR1E HTR1E GNB1 GNB1 HTR2C HTR2C ALOX5 ALOX5 PRKACA PRKACA PRKCA PRKCA MAPK3 MAPK3 CACNA1F CACNA1F ENSMLEP00000022028 ENSMLEP00000022028 ALOX12B ALOX12B ITPR3 ITPR3 GNB5 GNB5 PLA2G4C PLA2G4C PLCB2 PLCB2 LOC105542086 LOC105542086 MAPK1 MAPK1 GNB2 GNB2 LOC105548340 LOC105548340 PRKCB PRKCB PRKCG PRKCG ENSMLEP00000024805 ENSMLEP00000024805 KCNJ3 KCNJ3 ADCY5 ADCY5 GNGT2 GNGT2 ARAF ARAF GNAI3 GNAI3 GABRB1 GABRB1 CACNA1C CACNA1C CYP2C8 CYP2C8 ENSMLEP00000028401 ENSMLEP00000028401 HTR3E HTR3E GNAO1 GNAO1 JMJD7 JMJD7 GNG12 GNG12 HTR3A HTR3A SLC18A1 SLC18A1 CSDE1 CSDE1 MAOB MAOB GNG5 GNG5 GNG3 GNG3 LOC105549919 LOC105549919 DUSP1 DUSP1 NRAS NRAS PLA2G4B PLA2G4B GNG4 GNG4 APP APP LOC105538801 LOC105538801 CACNA1A CACNA1A TRPC1 TRPC1 CACNA1B CACNA1B HTR5A HTR5A PRKACB PRKACB PELP1 PELP1 LOC105553702 LOC105553702 GNGT1 GNGT1 GNAI1 GNAI1 KCNN2 KCNN2 HTR3B HTR3B CACNA1S CACNA1S BRAF BRAF RAPGEF3 RAPGEF3 GNG8 GNG8 HRAS HRAS KCNJ5 KCNJ5 ALOX15 ALOX15 GNG13 GNG13 PLCB3 PLCB3 LOC105553718 LOC105553718 PTGS2 PTGS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLA2G4DPhospholipase A2. (817 aa)
HTR65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (414 aa)
TPH2Tryptophan hydroxylase 2. (490 aa)
DDCDopa decarboxylase. (480 aa)
MAOAAmine oxidase. (527 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
GABRB2Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
PLA2G4EPhospholipase A2. (869 aa)
ENSMLEP00000001951Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (60 aa)
PLA2G4FPhospholipase A2. (849 aa)
LOC105534699Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (618 aa)
GNB4G protein subunit beta 4. (340 aa)
GNASGNAS complex locus. (998 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
PTGS1Prostaglandin-endoperoxide synthase 1. (632 aa)
HTR1D5-hydroxytryptamine receptor 1D. (377 aa)
GNAI2G protein subunit alpha i2. (352 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2663 aa)
GNB3G protein subunit beta 3. (340 aa)
ERASES cell expressed Ras. (233 aa)
ENSMLEP00000007417Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
HTR1F5-hydroxytryptamine receptor 1F. (366 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
HTR1A5-hydroxytryptamine receptor 1A. (422 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
LOC105550079Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CYP2J2Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family. (502 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
GNAQG protein subunit alpha q. (313 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2731 aa)
CYP2C18Cytochrome P450 family 2 subfamily C member 18; Belongs to the cytochrome P450 family. (436 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CYP4X1Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (510 aa)
ENSMLEP00000012301Protein kinase domain-containing protein. (294 aa)
LOC105552669Uncharacterized protein; Belongs to the peptidase C14A family. (215 aa)
HTR75-hydroxytryptamine receptor 7. (432 aa)
CYP4Z1Cytochrome P450 family 4 subfamily Z member 1. (336 aa)
PLA2G4APhospholipase A2. (749 aa)
GABRB3Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (475 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
HTR3C5-hydroxytryptamine receptor 3C; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (405 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
HTR45-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (428 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (411 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
CYP2W1Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (462 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (676 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
HTR1E5-hydroxytryptamine receptor 1E. (362 aa)
GNB1G protein subunit beta 1. (340 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
ENSMLEP00000022028Uncharacterized protein. (286 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R type. (701 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
GNB5G protein subunit beta 5. (357 aa)
PLA2G4CPhospholipase A2 group IVC. (469 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
LOC105542086G_PROTEIN_RECEP_F1_2 domain-containing protein. (372 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
GNB2G protein subunit beta 2. (340 aa)
LOC105548340Uncharacterized protein. (246 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
PRKCGProtein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (558 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (604 aa)
GNAI3G protein subunit alpha i3. (354 aa)
GABRB1Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (394 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2169 aa)
CYP2C8Cytochrome P450 family 2 subfamily C member 8; Belongs to the cytochrome P450 family. (487 aa)
ENSMLEP00000028401Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (65 aa)
HTR3E5-hydroxytryptamine receptor 3E; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (450 aa)
GNAO1G protein subunit alpha o1. (354 aa)
JMJD7Jumonji domain containing 7. (316 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
HTR3A5-hydroxytryptamine receptor 3A; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (521 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
CSDE1Cold shock domain containing E1. (844 aa)
MAOBAmine oxidase. (520 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC105549919Uncharacterized protein. (661 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PLA2G4BPhospholipase A2. (781 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
APPAmyloid beta precursor protein. (772 aa)
LOC105538801Uncharacterized protein; Belongs to the cytochrome P450 family. (497 aa)
CACNA1ACalcium voltage-gated channel subunit alpha1 A. (1985 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (809 aa)
CACNA1BCalcium voltage-gated channel subunit alpha1 B. (2001 aa)
HTR5A5-hydroxytryptamine receptor 5A. (357 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PELP1Proline, glutamate and leucine rich protein 1. (1174 aa)
LOC105553702Uncharacterized protein; Belongs to the cytochrome P450 family. (489 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNAI1G protein subunit alpha i1. (314 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (540 aa)
HTR3B5-hydroxytryptamine receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (441 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1846 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (925 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
ALOX15Arachidonate 15-lipoxygenase. (621 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
LOC105553718Uncharacterized protein; Belongs to the cytochrome P450 family. (489 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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