STRINGSTRING
KRT26 KRT26 PIK3R1 PIK3R1 KRT15 KRT15 CALM3 CALM3 HBEGF HBEGF HSP90AA1 HSP90AA1 PRKACB PRKACB FOS FOS KRT14 KRT14 ESR1 ESR1 KRT33B KRT33B LOC105548563 LOC105548563 PIK3R3 PIK3R3 KRT20 KRT20 NRAS NRAS HSPA2 HSPA2 CREB5 CREB5 CSDE1 CSDE1 CTSD CTSD LOC105542708 LOC105542708 GNAO1 GNAO1 MMP2 MMP2 PIK3CB PIK3CB KRT35 KRT35 AKT1 AKT1 ENSMLEP00000027485 ENSMLEP00000027485 LOC105542545 LOC105542545 KRT39 KRT39 ENSMLEP00000026929 ENSMLEP00000026929 ADCY3 ADCY3 GNAI3 GNAI3 PIK3CD PIK3CD KRT33A KRT33A GRM1 GRM1 ADCY5 ADCY5 KCNJ3 KCNJ3 ENSMLEP00000024805 ENSMLEP00000024805 ENSMLEP00000024790 ENSMLEP00000024790 LOC105538379 LOC105538379 EGFR EGFR LOC105548340 LOC105548340 ESR2 ESR2 ADCY1 ADCY1 MAPK1 MAPK1 KRT12 KRT12 PLCB2 PLCB2 GABBR1 GABBR1 ATF2 ATF2 KRT38 KRT38 ITPR3 ITPR3 SOS2 SOS2 AKT2 AKT2 SOS1 SOS1 ENSMLEP00000021360 ENSMLEP00000021360 LOC105553010 LOC105553010 MAPK3 MAPK3 PRKACA PRKACA CALML4 CALML4 NCOA2 NCOA2 MAP2K1 MAP2K1 PIK3CA PIK3CA CREB1 CREB1 CALM2 CALM2 ATF6B ATF6B LOC105535402 LOC105535402 IFITM10 IFITM10 KCNJ9 KCNJ9 PVALEF PVALEF KRT17 KRT17 GRB2 GRB2 NCOA1 NCOA1 ADCY2 ADCY2 LOC105534642 LOC105534642 ENSMLEP00000016358 ENSMLEP00000016358 TGFA TGFA HSPA8 HSPA8 MAP2K2 MAP2K2 SHC4 SHC4 CCDC170 CCDC170 NOS3 NOS3 LOC105538037 LOC105538037 KRT37 KRT37 FKBP4 FKBP4 CREB3L4 CREB3L4 ENSMLEP00000012897 ENSMLEP00000012897 TFF1 TFF1 OPRM1 OPRM1 LOC105531803 LOC105531803 ENSMLEP00000011359 ENSMLEP00000011359 RAF1 RAF1 LOC105549560 LOC105549560 KRT40 KRT40 CALM1 CALM1 KRT31 KRT31 KRT23 KRT23 ITPR1 ITPR1 GNAQ GNAQ PLCB4 PLCB4 PGR PGR KRT19 KRT19 KRAS KRAS PLCB1 PLCB1 ERAS ERAS KRT9 KRT9 CREB3L3 CREB3L3 KRT10 KRT10 ITPR2 ITPR2 GNAI2 GNAI2 BCL2 BCL2 HSP90AB1 HSP90AB1 ATF4 ATF4 NCOA3 NCOA3 ADCY8 ADCY8 HSP90B1 HSP90B1 HSPA1L HSPA1L GNAS GNAS CALML3 CALML3 KRT32 KRT32 GNAI1 GNAI1 LOC105540811 LOC105540811 ADCY7 ADCY7 ADCY9 ADCY9 LOC105550866 LOC105550866 ADCY4 ADCY4 CREB3 CREB3 POMC POMC ENSMLEP00000002165 ENSMLEP00000002165 PIK3R2 PIK3R2 KCNJ6 KCNJ6 SHC3 SHC3 LOC105554720 LOC105554720 CEP152 CEP152 CALML6 CALML6 CREB3L1 CREB3L1 KRT34 KRT34 ENSMLEP00000040190 ENSMLEP00000040190 GABBR2 GABBR2 KRT16 KRT16 PLCB3 PLCB3 KRT27 KRT27 ENSMLEP00000038520 ENSMLEP00000038520 KRT25 KRT25 CREB3L2 CREB3L2 ADCY6 ADCY6 FKBP5 FKBP5 KRT36 KRT36 SP1 SP1 AKT3 AKT3 GPER1 GPER1 SHC2 SHC2 KRT24 KRT24 RARA RARA KCNJ5 KCNJ5 KRT28 KRT28 HRAS HRAS SHC1 SHC1 EBAG9 EBAG9 SRC SRC MMP9 MMP9 KRT13 KRT13 ENSMLEP00000034218 ENSMLEP00000034218 PRKCD PRKCD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRT26Keratin 26; Belongs to the intermediate filament family. (437 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
KRT15Keratin 15; Belongs to the intermediate filament family. (456 aa)
CALM3Calmodulin 3. (149 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (823 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
KRT14Keratin 14; Belongs to the intermediate filament family. (475 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
KRT33BKeratin 33B; Belongs to the intermediate filament family. (404 aa)
LOC105548563Uncharacterized protein. (245 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
KRT20Keratin 20; Belongs to the intermediate filament family. (424 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (600 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
CSDE1Cold shock domain containing E1. (844 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (397 aa)
LOC105542708Uncharacterized protein. (462 aa)
GNAO1G protein subunit alpha o1. (354 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
KRT35Keratin 35; Belongs to the intermediate filament family. (455 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
ENSMLEP00000027485PID domain-containing protein. (488 aa)
LOC105542545HATPase_c domain-containing protein. (626 aa)
KRT39Keratin 39; Belongs to the intermediate filament family. (491 aa)
ENSMLEP00000026929IF rod domain-containing protein; Belongs to the intermediate filament family. (200 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
KRT33AKeratin 33A; Belongs to the intermediate filament family. (404 aa)
GRM1Glutamate metabotropic receptor 1. (961 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
ENSMLEP00000024790Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (294 aa)
LOC105538379HATPase_c domain-containing protein. (673 aa)
EGFRReceptor protein-tyrosine kinase. (1188 aa)
LOC105548340Uncharacterized protein. (246 aa)
ESR2Estrogen receptor 2. (530 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
KRT12Keratin 12; Belongs to the intermediate filament family. (459 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (966 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
KRT38Keratin 38; Belongs to the intermediate filament family. (452 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1317 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1299 aa)
ENSMLEP00000021360Uncharacterized protein. (128 aa)
LOC105553010IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
CALML4Calmodulin like 4. (193 aa)
NCOA2Nuclear receptor coactivator. (1468 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CALM2Calmodulin 2. (149 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
LOC105535402Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
IFITM10Interferon induced transmembrane protein 10. (192 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (411 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
KRT17Keratin 17; Belongs to the intermediate filament family. (432 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (901 aa)
LOC105534642Uncharacterized protein. (401 aa)
ENSMLEP00000016358Uncharacterized protein. (419 aa)
TGFATransforming growth factor alpha. (166 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (389 aa)
SHC4SHC adaptor protein 4. (630 aa)
CCDC170Coiled-coil domain containing 170. (696 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1155 aa)
LOC105538037IF rod domain-containing protein; Belongs to the intermediate filament family. (398 aa)
KRT37Keratin 37; Belongs to the intermediate filament family. (449 aa)
FKBP4Peptidylprolyl isomerase. (424 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (422 aa)
ENSMLEP00000012897Uncharacterized protein. (303 aa)
TFF1Trefoil factor 1. (84 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (485 aa)
LOC105531803Uncharacterized protein. (734 aa)
ENSMLEP00000011359Uncharacterized protein. (384 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
LOC105549560Uncharacterized protein; Belongs to the heat shock protein 70 family. (594 aa)
KRT40Keratin 40; Belongs to the intermediate filament family. (431 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
KRT31IF rod domain-containing protein; Belongs to the intermediate filament family. (416 aa)
KRT23Keratin 23; Belongs to the intermediate filament family. (422 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2731 aa)
GNAQG protein subunit alpha q. (313 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
PGRProgesterone receptor. (933 aa)
KRT19Keratin 19; Belongs to the intermediate filament family. (397 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
ERASES cell expressed Ras. (233 aa)
KRT9Keratin 9; Belongs to the intermediate filament family. (589 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (321 aa)
KRT10Keratin 10; Belongs to the intermediate filament family. (565 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2663 aa)
GNAI2G protein subunit alpha i2. (352 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
ATF4Activating transcription factor 4. (351 aa)
NCOA3Nuclear receptor coactivator. (1403 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
HSP90B1Heat shock protein 90 beta family member 1. (804 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
GNASGNAS complex locus. (998 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
KRT32Keratin 32; Belongs to the intermediate filament family. (453 aa)
GNAI1G protein subunit alpha i1. (314 aa)
LOC105540811Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
LOC105550866IF rod domain-containing protein; Belongs to the intermediate filament family. (420 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
POMCProopiomelanocortin. (265 aa)
ENSMLEP00000002165Uncharacterized protein; Belongs to the calmodulin family. (95 aa)
PIK3R2Uncharacterized protein. (587 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
SHC3SHC adaptor protein 3. (444 aa)
LOC105554720HATPase_c domain-containing protein. (658 aa)
CEP152Centrosomal protein 152. (1709 aa)
CALML6Calmodulin like 6. (181 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (466 aa)
KRT34Keratin 34; Belongs to the intermediate filament family. (436 aa)
ENSMLEP00000040190IF rod domain-containing protein; Belongs to the intermediate filament family. (407 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (890 aa)
KRT16Keratin 16; Belongs to the intermediate filament family. (476 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
KRT27Keratin 27; Belongs to the intermediate filament family. (459 aa)
ENSMLEP00000038520Uncharacterized protein; Belongs to the calmodulin family. (91 aa)
KRT25Keratin 25; Belongs to the intermediate filament family. (450 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
FKBP5Peptidylprolyl isomerase. (457 aa)
KRT36Keratin 36; Belongs to the intermediate filament family. (467 aa)
SP1Uncharacterized protein. (661 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
SHC2Uncharacterized protein. (483 aa)
KRT24Keratin 24; Belongs to the intermediate filament family. (525 aa)
RARARetinoic acid receptor alpha. (478 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
KRT28Keratin 28; Belongs to the intermediate filament family. (464 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SHC1SHC adaptor protein 1. (584 aa)
EBAG9Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (258 aa)
SRCTyrosine-protein kinase. (542 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
KRT13IF rod domain-containing protein; Belongs to the intermediate filament family. (450 aa)
ENSMLEP00000034218IF rod domain-containing protein; Belongs to the intermediate filament family. (383 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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