STRINGSTRING
PCK2 PCK2 AKT3 AKT3 TRAF2 TRAF2 G6PC2 G6PC2 TNFRSF1B TNFRSF1B PCK1 PCK1 G6PC G6PC CAMKK2 CAMKK2 AKT1 AKT1 ENSMLEP00000028290 ENSMLEP00000028290 NFKBIE NFKBIE ADIPOR1 ADIPOR1 PRKAG1 PRKAG1 PRKAB2 PRKAB2 ACSBG1 ACSBG1 ACSL1 ACSL1 PRKAA1 PRKAA1 LEP LEP ACSL4 ACSL4 TNFRSF1A TNFRSF1A ENSMLEP00000035415 ENSMLEP00000035415 ENSMLEP00000001965 ENSMLEP00000001965 ENSMLEP00000002280 ENSMLEP00000002280 POMC POMC LOC105541836 LOC105541836 PRKAA2 PRKAA2 SLC2A1 SLC2A1 LEPR LEPR ACSBG2 ACSBG2 MTOR MTOR PRKAB1 PRKAB1 MAPK10 MAPK10 RXRG RXRG PTPN11 PTPN11 MAPK9 MAPK9 PRKAG3 PRKAG3 ENSMLEP00000008990 ENSMLEP00000008990 IRS4 IRS4 RXRA RXRA IRS1 IRS1 SLC2A4 SLC2A4 RXRB RXRB ENSMLEP00000012128 ENSMLEP00000012128 STAT3 STAT3 NFKB1 NFKB1 JAK2 JAK2 CD36 CD36 PRKCQ PRKCQ ACSL3 ACSL3 MAPK8 MAPK8 IKBKG IKBKG ADIPOR2 ADIPOR2 IKBKB IKBKB ADIPOQ ADIPOQ NPY NPY PPARGC1A PPARGC1A ACSL6 ACSL6 G6PC3 G6PC3 SLC2A3 SLC2A3 TRADD TRADD PPARA PPARA AKT2 AKT2 CPT1A CPT1A CHUK CHUK AGRP AGRP RELA RELA CPT1C CPT1C NFKBIA NFKBIA CPT1B CPT1B ACSL5 ACSL5 PRKAG2 PRKAG2 NFKBIB NFKBIB STK11 STK11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
TNFRSF1BTNF receptor superfamily member 1B. (462 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
ENSMLEP00000028290Uncharacterized protein. (441 aa)
NFKBIENFKB inhibitor epsilon. (489 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (326 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (723 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (698 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (670 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
ENSMLEP00000035415Uncharacterized protein. (519 aa)
ENSMLEP00000001965Uncharacterized protein. (199 aa)
ENSMLEP00000002280Biotin carboxylation domain-containing protein. (205 aa)
POMCProopiomelanocortin. (265 aa)
LOC105541836MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (161 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
LEPRLeptin receptor. (1163 aa)
ACSBG2Acyl-CoA synthetase bubblegum family member 2. (560 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
MAPK10Mitogen-activated protein kinase. (477 aa)
RXRGRetinoid X receptor gamma. (463 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (656 aa)
MAPK9Mitogen-activated protein kinase. (395 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
ENSMLEP00000008990Uncharacterized protein. (858 aa)
IRS4Insulin receptor substrate 4. (1245 aa)
RXRARetinoid X receptor alpha. (452 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
RXRBRetinoid X receptor beta. (537 aa)
ENSMLEP00000012128Uncharacterized protein. (234 aa)
STAT3Signal transducer and activator of transcription. (693 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (396 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (706 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (249 aa)
NPYNeuropeptide Y. (97 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
ACSL6AMP-binding domain-containing protein. (725 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
SLC2A3MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (496 aa)
TRADDTNFRSF1A associated via death domain. (308 aa)
PPARAPeroxisome proliferator activated receptor alpha. (365 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (753 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
AGRPAgouti related neuropeptide. (132 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
CPT1CCarnitine palmitoyltransferase 1C. (780 aa)
NFKBIAANK_REP_REGION domain-containing protein. (305 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (642 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (683 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (506 aa)
NFKBIBNFKB inhibitor beta. (286 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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