STRINGSTRING
CALM2 CALM2 CALML6 CALML6 CREB3L1 CREB3L1 PLCB3 PLCB3 ENSMLEP00000038520 ENSMLEP00000038520 ENSMLEP00000038473 ENSMLEP00000038473 CREB3L2 CREB3L2 ADCY6 ADCY6 NR4A2 NR4A2 PDE2A PDE2A CAMK1G CAMK1G KCNJ5 KCNJ5 CAMK1 CAMK1 CACNA1S CACNA1S NPR1 NPR1 PRKD2 PRKD2 CALM3 CALM3 LOC105536288 LOC105536288 PRKACB PRKACB CAMK2A CAMK2A LOC105541286 LOC105541286 SCARB1 SCARB1 ARSI ARSI CREB5 CREB5 ATP2B1 ATP2B1 CACNA1I CACNA1I PRKD1 PRKD1 KCNK3 KCNK3 ENSMLEP00000028084 ENSMLEP00000028084 DAGLA DAGLA ADCY3 ADCY3 CACNA1C CACNA1C LIPE LIPE ADCY5 ADCY5 ENSMLEP00000024790 ENSMLEP00000024790 PRKCG PRKCG PRKCB PRKCB LOC105531512 LOC105531512 AGTR1 AGTR1 LOC105548340 LOC105548340 ADCY1 ADCY1 PLCB2 PLCB2 ATP2B4 ATP2B4 ATF2 ATF2 ITPR3 ITPR3 CACNA1G CACNA1G CAMK4 CAMK4 CACNA1F CACNA1F ATP1A4 ATP1A4 PRKCA PRKCA PRKACA PRKACA CALML4 CALML4 NPPA NPPA CACNA1D CACNA1D ATP1B4 ATP1B4 CREB1 CREB1 ATF6B ATF6B AGT AGT PVALEF PVALEF ORAI1 ORAI1 ATP2B3 ATP2B3 PRKD3 PRKD3 STAR STAR ADCY2 ADCY2 PRKCE PRKCE HSD3B2 HSD3B2 ENSMLEP00000014904 ENSMLEP00000014904 KCNK9 KCNK9 CREB3L4 CREB3L4 NR4A1 NR4A1 ATP1A1 ATP1A1 LDLR LDLR ATF1 ATF1 CALM1 CALM1 ATP1B2 ATP1B2 ATP1B1 ATP1B1 HSD3B1 HSD3B1 ITPR1 ITPR1 DAGLB DAGLB GNAQ GNAQ PLCB4 PLCB4 CYP11A1 CYP11A1 ATP1A2 ATP1A2 ENSMLEP00000008495 ENSMLEP00000008495 CAMK2G CAMK2G CAMK2B CAMK2B PLCB1 PLCB1 CREB3L3 CREB3L3 ITPR2 ITPR2 CACNA1H CACNA1H ATF4 ATF4 ADCY8 ADCY8 GNAS GNAS CALML3 CALML3 LOC105540811 LOC105540811 ADCY7 ADCY7 ADCY9 ADCY9 ADCY4 ADCY4 CREB3 CREB3 POMC POMC ATP1A3 ATP1A3 ENSMLEP00000002165 ENSMLEP00000002165 ATP2B2 ATP2B2 ATP1B3 ATP1B3 GNA11 GNA11 CAMK1D CAMK1D CAMK2D CAMK2D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CALM2Calmodulin 2. (149 aa)
CALML6Calmodulin like 6. (181 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (466 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
ENSMLEP00000038520Uncharacterized protein; Belongs to the calmodulin family. (91 aa)
ENSMLEP00000038473Uncharacterized protein; Belongs to the cytochrome P450 family. (145 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
PDE2APhosphodiesterase. (953 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1846 aa)
NPR1Guanylate cyclase. (900 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (888 aa)
CALM3Calmodulin 3. (149 aa)
LOC105536288Uncharacterized protein; Belongs to the cytochrome P450 family. (503 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
LOC105541286Uncharacterized protein; Belongs to the 3-beta-HSD family. (306 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (510 aa)
ARSIArylsulfatase family member I. (568 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2080 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
KCNK3Potassium channel subfamily K member. (375 aa)
ENSMLEP00000028084Uncharacterized protein. (108 aa)
DAGLADiacylglycerol lipase alpha. (1043 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2169 aa)
LIPELipase E, hormone sensitive type. (1041 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa)
ENSMLEP00000024790Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (294 aa)
PRKCGProtein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (558 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
LOC105531512Uncharacterized protein. (267 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
LOC105548340Uncharacterized protein. (246 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1241 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2360 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
CALML4Calmodulin like 4. (193 aa)
NPPANatriuretic peptide A. (153 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (238 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (901 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
HSD3B2Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. (373 aa)
ENSMLEP000000149043Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (361 aa)
KCNK9Potassium two pore domain channel subfamily K member 9; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (300 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (422 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (652 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1035 aa)
LDLRLow density lipoprotein receptor. (860 aa)
ATF1Activating transcription factor 1. (270 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
HSD3B1Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (373 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2731 aa)
DAGLBDiacylglycerol lipase beta. (678 aa)
GNAQG protein subunit alpha q. (313 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (521 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
ENSMLEP00000008495START domain-containing protein. (261 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (546 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (689 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (321 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2663 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2170 aa)
ATF4Activating transcription factor 4. (351 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
GNASGNAS complex locus. (998 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
LOC105540811Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
POMCProopiomelanocortin. (265 aa)
ATP1A3Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (844 aa)
ENSMLEP00000002165Uncharacterized protein; Belongs to the calmodulin family. (95 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1230 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (242 aa)
GNA11G protein subunit alpha 11. (307 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (354 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (441 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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