STRINGSTRING
HSD3B1 HSD3B1 KCNA1 KCNA1 POMC POMC CREB3 CREB3 ADCY4 ADCY4 ADCY9 ADCY9 ADCY7 ADCY7 GNAS GNAS ADCY8 ADCY8 ATF4 ATF4 CACNA1H CACNA1H KCNA10 KCNA10 ITPR2 ITPR2 CREB3L3 CREB3L3 PLCB1 PLCB1 KCNA5 KCNA5 PBX4 PBX4 ENSMLEP00000008495 ENSMLEP00000008495 KCNA3 KCNA3 CYP11A1 CYP11A1 PLCB4 PLCB4 GNAQ GNAQ ITPR1 ITPR1 LDLR LDLR NR5A1 NR5A1 NR4A1 NR4A1 CREB3L4 CREB3L4 ENSMLEP00000014904 ENSMLEP00000014904 PBX1 PBX1 HSD3B2 HSD3B2 ADCY2 ADCY2 STAR STAR ORAI1 ORAI1 MRAP MRAP AGT AGT ATF6B ATF6B CREB1 CREB1 CACNA1D CACNA1D PRKACA PRKACA CACNA1F CACNA1F CACNA1G CACNA1G ITPR3 ITPR3 ATF2 ATF2 PLCB2 PLCB2 ADCY1 ADCY1 LOC105548340 LOC105548340 AGTR1 AGTR1 LOC105531512 LOC105531512 ENSMLEP00000024790 ENSMLEP00000024790 ADCY5 ADCY5 CACNA1C CACNA1C ADCY3 ADCY3 ENSMLEP00000028084 ENSMLEP00000028084 KCNK3 KCNK3 NCEH1 NCEH1 CACNA1I CACNA1I CREB5 CREB5 LOC105548563 LOC105548563 SCARB1 SCARB1 LOC105541286 LOC105541286 PDE8B PDE8B CYP11B1 CYP11B1 PRKACB PRKACB PDE8A PDE8A CACNA1S CACNA1S KCNK2 KCNK2 SP1 SP1 ADCY6 ADCY6 CREB3L2 CREB3L2 ENSMLEP00000038473 ENSMLEP00000038473 CYP17A1 CYP17A1 PLCB3 PLCB3 NR0B1 NR0B1 CREB3L1 CREB3L1 KCNA2 KCNA2 GNA11 GNA11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HSD3B1Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (373 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
POMCProopiomelanocortin. (265 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
GNASGNAS complex locus. (998 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
ATF4Activating transcription factor 4. (351 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2170 aa)
KCNA10Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family. (511 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2663 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (321 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
PBX4PBX homeobox 4. (312 aa)
ENSMLEP00000008495START domain-containing protein. (261 aa)
KCNA3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (575 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (521 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
GNAQG protein subunit alpha q. (313 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2731 aa)
LDLRLow density lipoprotein receptor. (860 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (652 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (422 aa)
ENSMLEP000000149043Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (361 aa)
PBX1PBX homeobox 1. (430 aa)
HSD3B2Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. (373 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (901 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (238 aa)
MRAPMelanocortin 2 receptor accessory protein. (144 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2360 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
LOC105548340Uncharacterized protein. (246 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
LOC105531512Uncharacterized protein. (267 aa)
ENSMLEP00000024790Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (294 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2169 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
ENSMLEP00000028084Uncharacterized protein. (108 aa)
KCNK3Potassium channel subfamily K member. (375 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (448 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2080 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
LOC105548563Uncharacterized protein. (245 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (510 aa)
LOC105541286Uncharacterized protein; Belongs to the 3-beta-HSD family. (306 aa)
PDE8BPhosphodiesterase. (798 aa)
CYP11B1Cytochrome P450 family 11 subfamily B member 1; Belongs to the cytochrome P450 family. (574 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PDE8APhosphodiesterase. (794 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1846 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
SP1Uncharacterized protein. (661 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ENSMLEP00000038473Uncharacterized protein; Belongs to the cytochrome P450 family. (145 aa)
CYP17A1Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. (508 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (470 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (466 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (356 aa)
GNA11G protein subunit alpha 11. (307 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.