STRINGSTRING
ITPR2 ITPR2 CREB3L1 CREB3L1 IGFBP3 IGFBP3 STAT5B STAT5B PLCB3 PLCB3 MAPK14 MAPK14 CREB3L2 CREB3L2 ADCY6 ADCY6 ENSMLEP00000037519 ENSMLEP00000037519 AKT3 AKT3 SHC2 SHC2 SSTR5 SSTR5 HRAS HRAS SHC1 SHC1 CACNA1S CACNA1S GNAI1 GNAI1 PIK3R1 PIK3R1 LOC105551730 LOC105551730 BCAR1 BCAR1 ENSMLEP00000033441 ENSMLEP00000033441 MAP2K4 MAP2K4 PRKACB PRKACB MAPK13 MAPK13 FOS FOS EP300 EP300 PIK3R3 PIK3R3 NRAS NRAS STAT1 STAT1 CREB5 CREB5 GHRL GHRL CSDE1 CSDE1 PLCG1 PLCG1 PIK3CB PIK3CB AKT1 AKT1 ENSMLEP00000027485 ENSMLEP00000027485 MAPK12 MAPK12 ADCY3 ADCY3 CACNA1C CACNA1C GNAI3 GNAI3 PIK3CD PIK3CD ADCY5 ADCY5 ENSMLEP00000024805 ENSMLEP00000024805 ENSMLEP00000024790 ENSMLEP00000024790 PRKCG PRKCG GSK3B GSK3B PRKCB PRKCB PLCG2 PLCG2 LOC105548340 LOC105548340 ADCY1 ADCY1 MAPK1 MAPK1 MAPK11 MAPK11 PLCB2 PLCB2 GHRH GHRH ATF2 ATF2 ITPR3 ITPR3 MAP3K1 MAP3K1 SOS2 SOS2 AKT2 AKT2 CACNA1F CACNA1F SOS1 SOS1 MAPK3 MAPK3 PRKCA PRKCA PRKACA PRKACA LOC105551729 LOC105551729 LOC105551727 LOC105551727 MAP2K1 MAP2K1 CACNA1D CACNA1D PIK3CA PIK3CA CRKL CRKL CREB1 CREB1 SST SST ATF6B ATF6B ADCY10 ADCY10 GHRHR GHRHR GRB2 GRB2 GHR GHR ADCY2 ADCY2 ENSMLEP00000016394 ENSMLEP00000016394 MAPK8 MAPK8 MAP2K2 MAP2K2 PTK2 PTK2 MAP2K6 MAP2K6 SHC4 SHC4 CREB3L4 CREB3L4 JAK2 JAK2 GHSR GHSR STAT5A STAT5A STAT3 STAT3 MAP2K3 MAP2K3 LOC105551728 LOC105551728 RAF1 RAF1 IRS1 IRS1 ITPR1 ITPR1 GNAQ GNAQ PLCB4 PLCB4 IRS4 IRS4 POU1F1 POU1F1 KRAS KRAS MAPK9 MAPK9 PLCB1 PLCB1 ERAS ERAS SOCS2 SOCS2 MAPK10 MAPK10 CREB3L3 CREB3L3 GNAI2 GNAI2 IGF1 IGF1 ATF4 ATF4 MTOR MTOR ADCY8 ADCY8 CRK CRK GNAS GNAS SSTR1 SSTR1 ADCY7 ADCY7 LOC105551725 LOC105551725 ADCY9 ADCY9 ADCY4 ADCY4 CREB3 CREB3 SSTR2 SSTR2 SSTR3 SSTR3 PIK3R2 PIK3R2 GNA11 GNA11 SHC3 SHC3 CREBBP CREBBP JUNB JUNB CEP152 CEP152
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2663 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (466 aa)
IGFBP3Insulin like growth factor binding protein 3. (156 aa)
STAT5BSignal transducer and activator of transcription. (638 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ENSMLEP00000037519Uncharacterized protein. (87 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SHC2Uncharacterized protein. (483 aa)
SSTR5Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (223 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SHC1SHC adaptor protein 1. (584 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1846 aa)
GNAI1G protein subunit alpha i1. (314 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
LOC105551730Uncharacterized protein. (240 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
ENSMLEP00000033441LRRCT domain-containing protein. (373 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (373 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
MAPK13Mitogen-activated protein kinase. (397 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
EP300E1A binding protein p300. (2411 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
CSDE1Cold shock domain containing E1. (844 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1276 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
ENSMLEP00000027485PID domain-containing protein. (488 aa)
MAPK12Mitogen-activated protein kinase. (292 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2169 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
ENSMLEP00000024790Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (294 aa)
PRKCGProtein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (558 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1221 aa)
LOC105548340Uncharacterized protein. (246 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
MAPK11Mitogen-activated protein kinase. (224 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
GHRHGrowth hormone releasing hormone. (108 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1347 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1317 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1299 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
LOC105551729Uncharacterized protein. (196 aa)
LOC105551727Uncharacterized protein. (160 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
SSTSomatostatin. (116 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
ADCY10Adenylate cyclase 10. (1517 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
GHRGrowth hormone receptor. (645 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (901 aa)
ENSMLEP00000016394Uncharacterized protein. (246 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (389 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa)
SHC4SHC adaptor protein 4. (630 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (422 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT3Signal transducer and activator of transcription. (693 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
LOC105551728Uncharacterized protein. (248 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2731 aa)
GNAQG protein subunit alpha q. (313 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
IRS4Insulin receptor substrate 4. (1245 aa)
POU1F1POU domain protein. (317 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAPK9Mitogen-activated protein kinase. (395 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
ERASES cell expressed Ras. (233 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
MAPK10Mitogen-activated protein kinase. (477 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (321 aa)
GNAI2G protein subunit alpha i2. (352 aa)
IGF1Insulin like growth factor 1. (159 aa)
ATF4Activating transcription factor 4. (351 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CRKCRK proto-oncogene, adaptor protein. (245 aa)
GNASGNAS complex locus. (998 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
LOC105551725Uncharacterized protein. (217 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (418 aa)
PIK3R2Uncharacterized protein. (587 aa)
GNA11G protein subunit alpha 11. (307 aa)
SHC3SHC adaptor protein 3. (444 aa)
CREBBPCREB binding protein. (2423 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
CEP152Centrosomal protein 152. (1709 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.