40 items (Mandrillus leucophaeus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
	LOC105540905	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
	LOC105540906	14-3-3 protein sigma. (248 aa)
	PIK3R2	Uncharacterized protein. (587 aa)
	ATP1B3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (242 aa)
	ATP1A3	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (844 aa)
	IGF1	Insulin like growth factor 1. (159 aa)
	SCNN1G	Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (649 aa)
	ERAS	ES cell expressed Ras. (233 aa)
	KCNJ1	Potassium voltage-gated channel subfamily J member 1. (391 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	ATP1A2	Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
	ATP1B1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
	IRS1	Insulin receptor substrate 1. (1242 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (529 aa)
	ATP1A1	Sodium/potassium-transporting ATPase subunit alpha. (1035 aa)
	HSD11B2	Hydroxysteroid 11-beta dehydrogenase 2. (387 aa)
	SLC9A3R2	SLC9A3 regulator 2. (231 aa)
	NR3C2	Nuclear receptor subfamily 3 group C member 2. (988 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	SGK1	Non-specific serine/threonine protein kinase. (526 aa)
	SCNN1D	Sodium channel epithelial 1 delta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (689 aa)
	INSR	Tyrosine-protein kinase receptor. (1301 aa)
	ATP1B4	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	SCNN1A	Sodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (692 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
	ATP1A4	Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
	SCNN1B	Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (657 aa)
	MAPK1	Mitogen-activated protein kinase. (343 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
	FXYD4	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (88 aa)
	PRKCG	Protein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (558 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
	PIK3R3	Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	NEDD4L	NEDD4 like E3 ubiquitin protein ligase. (1257 aa)
	FXYD2	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (66 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP1A1	ATP1A3	ENSMLEP00000012958	ENSMLEP00000002216	Sodium/potassium-transporting ATPase subunit alpha.	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.921
ATP1A1	ATP1A4	ENSMLEP00000012958	ENSMLEP00000021545	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.903
ATP1A1	ATP1B1	ENSMLEP00000012958	ENSMLEP00000010467	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.998
ATP1A1	ATP1B2	ENSMLEP00000012958	ENSMLEP00000010691	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.952
ATP1A1	ATP1B3	ENSMLEP00000012958	ENSMLEP00000001978	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.949
ATP1A1	ATP1B4	ENSMLEP00000012958	ENSMLEP00000019572	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.938
ATP1A1	FXYD2	ENSMLEP00000012958	ENSMLEP00000037859	Sodium/potassium-transporting ATPase subunit alpha.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.996
ATP1A1	MAPK1	ENSMLEP00000012958	ENSMLEP00000023677	Sodium/potassium-transporting ATPase subunit alpha.	Mitogen-activated protein kinase.	0.861
ATP1A1	MAPK3	ENSMLEP00000012958	ENSMLEP00000021247	Sodium/potassium-transporting ATPase subunit alpha.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.861
ATP1A2	ATP1A3	ENSMLEP00000008697	ENSMLEP00000002216	Sodium/potassium-transporting ATPase subunit alpha.	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.921
ATP1A2	ATP1A4	ENSMLEP00000008697	ENSMLEP00000021545	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.903
ATP1A2	ATP1B1	ENSMLEP00000008697	ENSMLEP00000010467	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.998
ATP1A2	ATP1B2	ENSMLEP00000008697	ENSMLEP00000010691	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.952
ATP1A2	ATP1B3	ENSMLEP00000008697	ENSMLEP00000001978	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.949
ATP1A2	ATP1B4	ENSMLEP00000008697	ENSMLEP00000019572	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.938
ATP1A2	FXYD2	ENSMLEP00000008697	ENSMLEP00000037859	Sodium/potassium-transporting ATPase subunit alpha.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.996
ATP1A2	MAPK1	ENSMLEP00000008697	ENSMLEP00000023677	Sodium/potassium-transporting ATPase subunit alpha.	Mitogen-activated protein kinase.	0.861
ATP1A2	MAPK3	ENSMLEP00000008697	ENSMLEP00000021247	Sodium/potassium-transporting ATPase subunit alpha.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.861
ATP1A3	ATP1A1	ENSMLEP00000002216	ENSMLEP00000012958	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Sodium/potassium-transporting ATPase subunit alpha.	0.921
ATP1A3	ATP1A2	ENSMLEP00000002216	ENSMLEP00000008697	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Sodium/potassium-transporting ATPase subunit alpha.	0.921