(47 nodes) Vasopressin-regulated water reabsorption network (Mandrillus leucophaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CREB3L4	cAMP responsive element binding protein 3 like 4. (422 aa)
	ARHGDIA	Rho GDP dissociation inhibitor alpha. (204 aa)
	VAMP2	V-SNARE coiled-coil homology domain-containing protein. (118 aa)
	CREB3	cAMP responsive element binding protein 3. (372 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
	GNAS	GNAS complex locus. (998 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (321 aa)
	DYNC1LI2	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (431 aa)
	RAB5A	RAB5A, member RAS oncogene family. (215 aa)
	NSF	N-ethylmaleimide sensitive factor, vesicle fusing ATPase. (740 aa)
	ENSMLEP00000011985	Dynein light chain. (80 aa)
	RAB11A	RAB11A, member RAS oncogene family. (198 aa)
	DYNC1I2	Dynein cytoplasmic 1 intermediate chain 2. (638 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	RAB5B	RAB5B, member RAS oncogene family. (221 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
	ENSMLEP00000023777	Uncharacterized protein. (177 aa)
	LOC105548340	Uncharacterized protein. (246 aa)
	RAB5C	RAB5C, member RAS oncogene family. (249 aa)
	ARHGDIB	Rho GDP dissociation inhibitor beta. (201 aa)
	DCTN1	CAP-Gly domain-containing protein. (1278 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
	DYNLL2	Dynein light chain. (89 aa)
	RAB11B	Uncharacterized protein. (448 aa)
	DYNC2H1	Dynein cytoplasmic 2 heavy chain 1. (4278 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
	DCTN2	Dynactin subunit 2. (406 aa)
	STX4	Syntaxin 4; Belongs to the syntaxin family. (297 aa)
	AQP2	Aquaporin 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	DYNC1H1	Dynein cytoplasmic 1 heavy chain 1. (4513 aa)
	DYNLL1	Dynein light chain. (89 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	AQP10	Aquaporin 10; Belongs to the MIP/aquaporin (TC 1.A.8) family. (301 aa)
	RAB17	RAB17, member RAS oncogene family. (212 aa)
	ARHGDIG	Rho GDP dissociation inhibitor gamma. (217 aa)
	AQP4	Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
	AQP3	Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
	DCTN6	Dynactin subunit 6. (190 aa)
	DYNC2LI1	Dynein cytoplasmic 2 light intermediate chain 1. (351 aa)
	DYNC1I1	Dynein cytoplasmic 1 intermediate chain 1. (645 aa)
	DYNC1LI1	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (523 aa)
	AVPR2	Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (368 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (520 aa)
	DCTN4	Dynactin subunit 4. (467 aa)
	DCTN5	Dynactin subunit 5. (152 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (466 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY3	ADCY6	ENSMLEP00000026920	ENSMLEP00000037902	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.896
ADCY3	ADCY9	ENSMLEP00000026920	ENSMLEP00000003506	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.899
ADCY3	GNAS	ENSMLEP00000026920	ENSMLEP00000004090	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.947
ADCY3	LOC105548340	ENSMLEP00000026920	ENSMLEP00000024031	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.992
ADCY3	PRKACA	ENSMLEP00000026920	ENSMLEP00000020813	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.904
ADCY3	PRKACB	ENSMLEP00000026920	ENSMLEP00000032707	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.998
ADCY6	ADCY3	ENSMLEP00000037902	ENSMLEP00000026920	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.896
ADCY6	ADCY9	ENSMLEP00000037902	ENSMLEP00000003506	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.907
ADCY6	AVPR2	ENSMLEP00000037902	ENSMLEP00000037597	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	0.400
ADCY6	GNAS	ENSMLEP00000037902	ENSMLEP00000004090	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.971
ADCY6	LOC105548340	ENSMLEP00000037902	ENSMLEP00000024031	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.992
ADCY6	PRKACA	ENSMLEP00000037902	ENSMLEP00000020813	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.824
ADCY6	PRKACB	ENSMLEP00000037902	ENSMLEP00000032707	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.921
ADCY9	ADCY3	ENSMLEP00000003506	ENSMLEP00000026920	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.899
ADCY9	ADCY6	ENSMLEP00000003506	ENSMLEP00000037902	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.907
ADCY9	GNAS	ENSMLEP00000003506	ENSMLEP00000004090	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	GNAS complex locus.	0.986
ADCY9	LOC105548340	ENSMLEP00000003506	ENSMLEP00000024031	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.886
ADCY9	PRKACA	ENSMLEP00000003506	ENSMLEP00000020813	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.806
ADCY9	PRKACB	ENSMLEP00000003506	ENSMLEP00000032707	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.909
AQP10	AQP2	ENSMLEP00000032973	ENSMLEP00000031493	Aquaporin 10; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin 2; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.828