(40 nodes) Nicotine addiction network (Mandrillus leucophaeus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CHRNA6	Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
	GABRQ	Gamma-aminobutyric acid type A receptor theta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (632 aa)
	GABRG3	Gamma-aminobutyric acid type A receptor gamma3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (449 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1422 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (916 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (702 aa)
	GABRB1	Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (394 aa)
	GABRR1	Gamma-aminobutyric acid type A receptor rho1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (479 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
	GRIN2D	Glutamate ionotropic receptor NMDA type subunit 2D. (747 aa)
	SLC17A6	Solute carrier family 17 member 6. (582 aa)
	CHRNA4	Cholinergic receptor nicotinic alpha 4 subunit. (600 aa)
	GABRA4	Gamma-aminobutyric acid type A receptor alpha4 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (554 aa)
	GABRR2	Gamma-aminobutyric acid type A receptor rho2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (465 aa)
	GRIA3	Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
	ENSMLEP00000001003	CaM_bdg_C0 domain-containing protein. (124 aa)
	GABRB2	Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
	GABRP	Gamma-aminobutyric acid type A receptor pi subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (440 aa)
	GABRG2	Gamma-aminobutyric acid type A receptor gamma2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (515 aa)
	GABRA3	Gamma-aminobutyric acid type A receptor alpha3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (492 aa)
	GABRG1	Gamma-aminobutyric acid type A receptor gamma1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (465 aa)
	GRIA4	Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
	GABRB3	Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (475 aa)
	GABRA5	Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
	GABRR3	Gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene); Belongs to the ligand-gated ion channel (TC 1.A.9) family. (467 aa)
	CHRNB2	Cholinergic receptor nicotinic beta 2 subunit. (502 aa)
	SLC32A1	Solute carrier family 32 member 1. (525 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
	ENSMLEP00000018922	ANF_receptor domain-containing protein. (356 aa)
	SLC17A7	Solute carrier family 17 member 7. (560 aa)
	GABRA2	Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (511 aa)
	GABRE	Gamma-aminobutyric acid type A receptor epsilon subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (506 aa)
	GABRA6	Gamma-aminobutyric acid type A receptor alpha6 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (453 aa)
	CHRNA7	Uncharacterized protein. (473 aa)
	GABRA1	Gamma-aminobutyric acid type A receptor alpha1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (471 aa)
	GRIN3B	Glutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (691 aa)
	CACNA1B	Calcium voltage-gated channel subunit alpha1 B. (2001 aa)
	GABRD	Gamma-aminobutyric acid type A receptor delta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (461 aa)
	CACNA1A	Calcium voltage-gated channel subunit alpha1 A. (1985 aa)
	SLC17A8	Solute carrier family 17 member 8. (589 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACNA1A	CACNA1B	ENSMLEP00000032115	ENSMLEP00000032389	Calcium voltage-gated channel subunit alpha1 A.	Calcium voltage-gated channel subunit alpha1 B.	0.938
CACNA1B	CACNA1A	ENSMLEP00000032389	ENSMLEP00000032115	Calcium voltage-gated channel subunit alpha1 B.	Calcium voltage-gated channel subunit alpha1 A.	0.938
CHRNA4	CHRNA6	ENSMLEP00000022874	ENSMLEP00000007191	Cholinergic receptor nicotinic alpha 4 subunit.	Cholinergic receptor nicotinic alpha 6 subunit.	0.830
CHRNA4	CHRNA7	ENSMLEP00000022874	ENSMLEP00000036573	Cholinergic receptor nicotinic alpha 4 subunit.	Uncharacterized protein.	0.809
CHRNA4	CHRNB2	ENSMLEP00000022874	ENSMLEP00000015900	Cholinergic receptor nicotinic alpha 4 subunit.	Cholinergic receptor nicotinic beta 2 subunit.	0.984
CHRNA6	CHRNA4	ENSMLEP00000007191	ENSMLEP00000022874	Cholinergic receptor nicotinic alpha 6 subunit.	Cholinergic receptor nicotinic alpha 4 subunit.	0.830
CHRNA6	CHRNA7	ENSMLEP00000007191	ENSMLEP00000036573	Cholinergic receptor nicotinic alpha 6 subunit.	Uncharacterized protein.	0.813
CHRNA6	CHRNB2	ENSMLEP00000007191	ENSMLEP00000015900	Cholinergic receptor nicotinic alpha 6 subunit.	Cholinergic receptor nicotinic beta 2 subunit.	0.568
CHRNA7	CHRNA4	ENSMLEP00000036573	ENSMLEP00000022874	Uncharacterized protein.	Cholinergic receptor nicotinic alpha 4 subunit.	0.809
CHRNA7	CHRNA6	ENSMLEP00000036573	ENSMLEP00000007191	Uncharacterized protein.	Cholinergic receptor nicotinic alpha 6 subunit.	0.813
CHRNA7	CHRNB2	ENSMLEP00000036573	ENSMLEP00000015900	Uncharacterized protein.	Cholinergic receptor nicotinic beta 2 subunit.	0.753
CHRNA7	ENSMLEP00000001003	ENSMLEP00000036573	ENSMLEP00000001003	Uncharacterized protein.	CaM_bdg_C0 domain-containing protein.	0.704
CHRNA7	ENSMLEP00000018922	ENSMLEP00000036573	ENSMLEP00000018922	Uncharacterized protein.	ANF_receptor domain-containing protein.	0.919
CHRNA7	GABRA6	ENSMLEP00000036573	ENSMLEP00000040001	Uncharacterized protein.	Gamma-aminobutyric acid type A receptor alpha6 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.476
CHRNA7	GRIN2A	ENSMLEP00000036573	ENSMLEP00000028020	Uncharacterized protein.	Glutamate ionotropic receptor NMDA type subunit 2A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.	0.913
CHRNA7	GRIN2C	ENSMLEP00000036573	ENSMLEP00000027084	Uncharacterized protein.	Glutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.	0.890
CHRNA7	GRIN2D	ENSMLEP00000036573	ENSMLEP00000024154	Uncharacterized protein.	Glutamate ionotropic receptor NMDA type subunit 2D.	0.892
CHRNB2	CHRNA4	ENSMLEP00000015900	ENSMLEP00000022874	Cholinergic receptor nicotinic beta 2 subunit.	Cholinergic receptor nicotinic alpha 4 subunit.	0.984
CHRNB2	CHRNA6	ENSMLEP00000015900	ENSMLEP00000007191	Cholinergic receptor nicotinic beta 2 subunit.	Cholinergic receptor nicotinic alpha 6 subunit.	0.568
CHRNB2	CHRNA7	ENSMLEP00000015900	ENSMLEP00000036573	Cholinergic receptor nicotinic beta 2 subunit.	Uncharacterized protein.	0.753