STRINGSTRING
CASP8 CASP8 HLA-DOB HLA-DOB ENSMLEP00000040499 ENSMLEP00000040499 LAMB4 LAMB4 LAMB1 LAMB1 ENSMLEP00000038532 ENSMLEP00000038532 MAPK14 MAPK14 CD40LG CD40LG AKT3 AKT3 TGFB2 TGFB2 LOC105540670 LOC105540670 CASP9 CASP9 RELA RELA BIRC3 BIRC3 TNFRSF1A TNFRSF1A GNAI1 GNAI1 XIAP XIAP LOC105536146 LOC105536146 MAPK13 MAPK13 LAMC1 LAMC1 IL10RB IL10RB TGFB3 TGFB3 LAMA4 LAMA4 HLA-DMA HLA-DMA TAB2 TAB2 MAP3K7 MAP3K7 PPP1R14B PPP1R14B LAMC2 LAMC2 STAT1 STAT1 HSPA2 HSPA2 ITGA6 ITGA6 LAMA3 LAMA3 LOC105542708 LOC105542708 GNAO1 GNAO1 ITGB1 ITGB1 JAK1 JAK1 AKT1 AKT1 NOS2 NOS2 IFNGR2 IFNGR2 HLA-DOA HLA-DOA NFKBIB NFKBIB MAPK12 MAPK12 GNAI3 GNAI3 NFKBIA NFKBIA C7orf31 C7orf31 LAMA1 LAMA1 LAMA5 LAMA5 TAB1 TAB1 LOC105531108 LOC105531108 MAPK1 MAPK1 CHUK CHUK MAPK11 MAPK11 LAMB3 LAMB3 BIRC2 BIRC2 IFNG IFNG AKT2 AKT2 LAMC3 LAMC3 PIK3R6 PIK3R6 LOC105553177 LOC105553177 MAPK3 MAPK3 LOC105537712 LOC105537712 ALOX5 ALOX5 LOC105537711 LOC105537711 IL12B IL12B LOC105535402 LOC105535402 IL10RA IL10RA BCL2L1 BCL2L1 IKBKB IKBKB LOC105531112 LOC105531112 IL12A IL12A IKBKG IKBKG ENSMLEP00000016358 ENSMLEP00000016358 MAPK8 MAPK8 MYD88 MYD88 HSPA8 HSPA8 IL10 IL10 MAP2K6 MAP2K6 IRAK4 IRAK4 TLR4 TLR4 JAK2 JAK2 NFKB1 NFKB1 LOC105552669 LOC105552669 STAT3 STAT3 MAP2K3 MAP2K3 LDLR LDLR PDPK1 PDPK1 PIK3CG PIK3CG LOC105549560 LOC105549560 CD40 CD40 LOC105540229 LOC105540229 PPIF PPIF IFNGR1 IFNGR1 IRAK1 IRAK1 PIK3R5 PIK3R5 CASP3 CASP3 TYK2 TYK2 ENSMLEP00000007765 ENSMLEP00000007765 MAPK9 MAPK9 LOC105540228 LOC105540228 LAMA2 LAMA2 ENSMLEP00000006706 ENSMLEP00000006706 CCR5 CCR5 CIITA CIITA LOC105533249 LOC105533249 MAPK10 MAPK10 GNAI2 GNAI2 BCL2 BCL2 LOC105537710 LOC105537710 HSPA1L HSPA1L IRGM IRGM BAD BAD LOC105537163 LOC105537163 LOC105537709 LOC105537709 TGFB1 TGFB1 HLA-DRA HLA-DRA TRAF6 TRAF6 BIRC7 BIRC7 LOC105553485 LOC105553485 LY96 LY96 LOC105536632 LOC105536632 LOC105553918 LOC105553918 TLR2 TLR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASP8Caspase 8; Belongs to the peptidase C14A family. (479 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
ENSMLEP00000040499Uncharacterized protein. (147 aa)
LAMB4Laminin subunit beta 4. (1729 aa)
LAMB1Laminin subunit beta 1. (1786 aa)
ENSMLEP00000038532Uncharacterized protein. (260 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LOC105540670Ig-like domain-containing protein. (261 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (400 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
GNAI1G protein subunit alpha i1. (314 aa)
XIAPX-linked inhibitor of apoptosis. (484 aa)
LOC105536146Ig-like domain-containing protein. (327 aa)
MAPK13Mitogen-activated protein kinase. (397 aa)
LAMC1Laminin subunit gamma 1. (1575 aa)
IL10RBInterleukin 10 receptor subunit beta. (325 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (290 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PPP1R14BUncharacterized protein. (127 aa)
LAMC2Laminin subunit gamma 2. (1193 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (600 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1069 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
LOC105542708Uncharacterized protein. (462 aa)
GNAO1G protein subunit alpha o1. (354 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (748 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1147 aa)
IFNGR2Interferon gamma receptor 2. (408 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
NFKBIBNFKB inhibitor beta. (286 aa)
MAPK12Mitogen-activated protein kinase. (292 aa)
GNAI3G protein subunit alpha i3. (354 aa)
NFKBIAANK_REP_REGION domain-containing protein. (305 aa)
C7orf31Chromosome 7 open reading frame 31. (590 aa)
LAMA1Laminin subunit alpha 1. (3008 aa)
LAMA5Laminin subunit alpha 5. (3494 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
LOC105531108Ig-like domain-containing protein; Belongs to the MHC class II family. (269 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MAPK11Mitogen-activated protein kinase. (224 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LAMC3Laminin subunit gamma 3. (1423 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
LOC105553177Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
LOC105537712Ig-like domain-containing protein. (239 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
LOC105537711Ig-like domain-containing protein. (266 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
LOC105535402Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
IL10RAInterleukin 10 receptor subunit alpha. (576 aa)
BCL2L1BCL2 like 1. (233 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (706 aa)
LOC105531112Ig-like domain-containing protein. (263 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (396 aa)
ENSMLEP00000016358Uncharacterized protein. (419 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
IL10Interleukin 10. (178 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
LOC105552669Uncharacterized protein; Belongs to the peptidase C14A family. (215 aa)
STAT3Signal transducer and activator of transcription. (693 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
LDLRLow density lipoprotein receptor. (860 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (529 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1082 aa)
LOC105549560Uncharacterized protein; Belongs to the heat shock protein 70 family. (594 aa)
CD40CD40 molecule. (278 aa)
LOC105540229Ig-like domain-containing protein; Belongs to the MHC class II family. (269 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (142 aa)
IFNGR1Interferon gamma receptor 1. (488 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (610 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (881 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
ENSMLEP00000007765Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MAPK9Mitogen-activated protein kinase. (395 aa)
LOC105540228Ig-like domain-containing protein. (258 aa)
LAMA2Laminin subunit alpha 2. (2528 aa)
ENSMLEP00000006706Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (96 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
CIITAClass II major histocompatibility complex transactivator. (1129 aa)
LOC105533249Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
MAPK10Mitogen-activated protein kinase. (477 aa)
GNAI2G protein subunit alpha i2. (352 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
LOC105537710Ig-like domain-containing protein. (228 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
IRGMImmunity related GTPase M. (159 aa)
BADBCL2 associated agonist of cell death. (167 aa)
LOC105537163Ig-like domain-containing protein. (264 aa)
LOC105537709Ig-like domain-containing protein; Belongs to the MHC class II family. (256 aa)
TGFB1Transforming growth factor beta 1. (226 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
BIRC7Baculoviral IAP repeat containing 7. (297 aa)
LOC105553485Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LY96Lymphocyte antigen 96. (160 aa)
LOC105536632Uncharacterized protein. (598 aa)
LOC105553918Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TLR2Toll-like receptor. (784 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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