STRINGSTRING
IFIH1 IFIH1 TLR2 TLR2 CDK2 CDK2 LOC105553918 LOC105553918 IRF9 IRF9 OAS1 OAS1 LOC105553485 LOC105553485 PIK3R2 PIK3R2 TLR9 TLR9 OAS2 OAS2 CD209 CD209 EIF2AK3 EIF2AK3 TRAF6 TRAF6 STAT2 STAT2 BAD BAD BAX BAX RAB9A RAB9A CD3G CD3G HSPA1L HSPA1L TNFAIP3 TNFAIP3 BCL2 BCL2 MAPK10 MAPK10 LOC105533249 LOC105533249 TP73 TP73 ENSMLEP00000006706 ENSMLEP00000006706 CSNK2A2 CSNK2A2 MAPK9 MAPK9 RAB9B RAB9B ENSMLEP00000007765 ENSMLEP00000007765 TYK2 TYK2 CASP3 CASP3 IRAK1 IRAK1 ADAR ADAR CDKN1B CDKN1B LOC105549560 LOC105549560 DDX58 DDX58 ENSMLEP00000012170 ENSMLEP00000012170 ENSMLEP00000012226 ENSMLEP00000012226 STAT3 STAT3 EIF2AK1 EIF2AK1 LOC105552669 LOC105552669 NFKB1 NFKB1 STAT5A STAT5A TLR4 TLR4 IL2RG IL2RG CD3D CD3D CCNE2 CCNE2 IRAK4 IRAK4 IKBKE IKBKE IL1A IL1A HSPA8 HSPA8 ENSMLEP00000015528 ENSMLEP00000015528 MYD88 MYD88 IL2RB IL2RB MAPK8 MAPK8 CASP8 CASP8 MX1 MX1 ENSMLEP00000016358 ENSMLEP00000016358 IKBKG IKBKG IL12A IL12A IKBKB IKBKB TRAF3 TRAF3 RACK1 RACK1 BCL2L1 BCL2L1 LOC105535402 LOC105535402 BAK1 BAK1 EIF2AK2 EIF2AK2 BID BID IFNAR2 IFNAR2 IL12B IL12B CCND3 CCND3 PIK3CA PIK3CA IL6 IL6 CLEC4G CLEC4G JAK3 JAK3 TRADD TRADD SLAMF1 SLAMF1 AKT2 AKT2 TBK1 TBK1 CHUK CHUK APAF1 APAF1 GSK3B GSK3B IL1B IL1B C7orf31 C7orf31 MSN MSN IL2RA IL2RA CDK6 CDK6 MX2 MX2 PIK3CD PIK3CD NFKBIA NFKBIA CDK4 CDK4 LOC105537894 LOC105537894 FASLG FASLG CD28 CD28 CSNK2A1 CSNK2A1 NFKBIB NFKBIB FADD FADD AKT1 AKT1 EIF2AK4 EIF2AK4 PIK3CB PIK3CB JAK1 JAK1 LOC105542708 LOC105542708 ENSMLEP00000029067 ENSMLEP00000029067 EIF3H EIF3H HSPA2 HSPA2 STAT1 STAT1 PPP1R14B PPP1R14B IRF3 IRF3 MAP3K7 MAP3K7 TAB2 TAB2 CCNE1 CCNE1 PIK3R3 PIK3R3 FAS FAS CD46 CD46 TRAC TRAC LOC105546382 LOC105546382 FOS FOS OAS3 OAS3 ENSMLEP00000033047 ENSMLEP00000033047 PIK3R1 PIK3R1 TLR7 TLR7 CCND2 CCND2 CBLB CBLB RCHY1 RCHY1 EIF2S1 EIF2S1 IL2 IL2 RELA RELA CSNK2B CSNK2B CASP9 CASP9 CD3E CD3E MAVS MAVS AKT3 AKT3 TP53 TP53 IRF7 IRF7 LIMCH1 LIMCH1 STAT5B STAT5B ENSMLEP00000040499 ENSMLEP00000040499 IFNAR1 IFNAR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFIH1Interferon induced with helicase C domain 1. (1025 aa)
TLR2Toll-like receptor. (784 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
LOC105553918Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IRF9Interferon regulatory factor 9. (392 aa)
OAS12'-5'-oligoadenylate synthetase 1. (400 aa)
LOC105553485Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PIK3R2Uncharacterized protein. (587 aa)
TLR9TIR domain-containing protein. (1033 aa)
OAS22'-5'-oligoadenylate synthetase 2. (719 aa)
CD209CD209 molecule. (381 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1012 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
BADBCL2 associated agonist of cell death. (167 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
RAB9ARAB9A, member RAS oncogene family. (201 aa)
CD3GCD3g molecule. (166 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
MAPK10Mitogen-activated protein kinase. (477 aa)
LOC105533249Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (601 aa)
ENSMLEP00000006706Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (96 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (323 aa)
MAPK9Mitogen-activated protein kinase. (395 aa)
RAB9BRAB9B, member RAS oncogene family. (201 aa)
ENSMLEP00000007765Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (610 aa)
ADARAdenosine deaminase RNA specific. (1227 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
LOC105549560Uncharacterized protein; Belongs to the heat shock protein 70 family. (594 aa)
DDX58DExD/H-box helicase 58. (925 aa)
ENSMLEP00000012170Ig-like domain-containing protein. (147 aa)
ENSMLEP00000012226Uncharacterized protein. (198 aa)
STAT3Signal transducer and activator of transcription. (693 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (631 aa)
LOC105552669Uncharacterized protein; Belongs to the peptidase C14A family. (215 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
CD3DCD3d molecule. (171 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (697 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
ENSMLEP00000015528Uncharacterized protein. (184 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (479 aa)
MX1MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (661 aa)
ENSMLEP00000016358Uncharacterized protein. (419 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (396 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (706 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
RACK1Receptor for activated C kinase 1. (318 aa)
BCL2L1BCL2 like 1. (233 aa)
LOC105535402Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (551 aa)
BIDBH3 interacting domain death agonist. (244 aa)
IFNAR2Uncharacterized protein. (516 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (242 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IL6Interleukin 6. (226 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
JAK3Tyrosine-protein kinase. (1030 aa)
TRADDTNFRSF1A associated via death domain. (308 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (356 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TBK1TANK binding kinase 1. (729 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
C7orf31Chromosome 7 open reading frame 31. (590 aa)
MSNMoesin. (581 aa)
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
MX2MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (715 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
NFKBIAANK_REP_REGION domain-containing protein. (305 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
LOC105537894Uncharacterized protein. (192 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
CD28CD28 molecule. (220 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
NFKBIBNFKB inhibitor beta. (286 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1644 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
LOC105542708Uncharacterized protein. (462 aa)
ENSMLEP00000029067Uncharacterized protein. (101 aa)
EIF3HEukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (366 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (600 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
PPP1R14BUncharacterized protein. (127 aa)
IRF3Interferon regulatory factor 3. (422 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (407 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
FASFas cell surface death receptor. (331 aa)
CD46CD46 molecule. (399 aa)
TRACT cell receptor alpha constant. (110 aa)
LOC105546382Uncharacterized protein. (298 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1088 aa)
ENSMLEP00000033047Uncharacterized protein. (67 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
CBLBCbl proto-oncogene B. (982 aa)
RCHY1Ring finger and CHY zinc finger domain containing 1. (261 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
CSNK2BUncharacterized protein. (298 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (400 aa)
CD3ECD3e molecule. (198 aa)
MAVSMitochondrial antiviral signaling protein. (541 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
IRF7Interferon regulatory factor 7. (517 aa)
LIMCH1LIM and calponin homology domains 1. (1467 aa)
STAT5BSignal transducer and activator of transcription. (638 aa)
ENSMLEP00000040499Uncharacterized protein. (147 aa)
IFNAR1Uncharacterized protein. (332 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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