STRINGSTRING
PAK1 PAK1 CRKL CRKL PIK3CA PIK3CA MAP2K1 MAP2K1 MAPK3 MAPK3 RAPGEF1 RAPGEF1 PRCC PRCC SOS1 SOS1 AKT2 AKT2 SOS2 SOS2 ENSMLEP00000022706 ENSMLEP00000022706 HGF HGF MAPK1 MAPK1 ENSMLEP00000024805 ENSMLEP00000024805 TFE3 TFE3 ARAF ARAF PIK3CD PIK3CD ARNT2 ARNT2 EGLN2 EGLN2 EPAS1 EPAS1 RAP1B RAP1B AKT1 AKT1 PIK3CB PIK3CB ENSMLEP00000028290 ENSMLEP00000028290 LOC105553738 LOC105553738 VEGFA VEGFA ETS1 ETS1 CSDE1 CSDE1 NRAS NRAS PPP1R14B PPP1R14B PDGFB PDGFB PIK3R3 PIK3R3 EP300 EP300 TGFB3 TGFB3 PAK3 PAK3 ELOC ELOC PIK3R1 PIK3R1 LOC105542528 LOC105542528 BRAF BRAF ENSMLEP00000035415 ENSMLEP00000035415 PAK4 PAK4 CDC42 CDC42 HRAS HRAS TGFB2 TGFB2 AKT3 AKT3 ENSMLEP00000038844 ENSMLEP00000038844 ARNT ARNT RBX1 RBX1 ENSMLEP00000040499 ENSMLEP00000040499 EGLN3 EGLN3 TGFA TGFA HIF1A HIF1A GAB1 GAB1 FLCN FLCN FH FH GRB2 GRB2 PIK3R2 PIK3R2 TGFB1 TGFB1 BAD BAD PAK5 PAK5 SLC2A1 SLC2A1 MAP2K2 MAP2K2 CUL2 CUL2 PAK6 PAK6 CRK CRK ENSMLEP00000004779 ENSMLEP00000004779 MET MET PTPN11 PTPN11 ERAS ERAS PAK2 PAK2 LOC105530991 LOC105530991 KRAS KRAS RAP1A RAP1A ENSMLEP00000015363 ENSMLEP00000015363 CREBBP CREBBP ENSMLEP00000018399 ENSMLEP00000018399 ENSMLEP00000018677 ENSMLEP00000018677 RAF1 RAF1 CDKN1A CDKN1A LOC105537007 LOC105537007 ENSMLEP00000012128 ENSMLEP00000012128 ENSMLEP00000012301 ENSMLEP00000012301 EGLN1 EGLN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAK1Non-specific serine/threonine protein kinase. (545 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1100 aa)
PRCCProline rich mitotic checkpoint control factor. (491 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1299 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1317 aa)
ENSMLEP00000022706Zf-rbx1 domain-containing protein. (93 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (575 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (604 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (717 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (405 aa)
EPAS1Endothelial PAS domain protein 1. (869 aa)
RAP1BUncharacterized protein. (184 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ENSMLEP00000028290Uncharacterized protein. (441 aa)
LOC105553738Uncharacterized protein. (160 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (210 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
CSDE1Cold shock domain containing E1. (844 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PPP1R14BUncharacterized protein. (127 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
EP300E1A binding protein p300. (2411 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
ELOCElongin C; Belongs to the SKP1 family. (96 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
LOC105542528Uncharacterized protein. (173 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
ENSMLEP00000035415Uncharacterized protein. (519 aa)
PAK4Non-specific serine/threonine protein kinase. (349 aa)
CDC42Uncharacterized protein. (191 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSMLEP00000038844VHL domain-containing protein. (120 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (734 aa)
RBX1RING-type domain-containing protein. (108 aa)
ENSMLEP00000040499Uncharacterized protein. (147 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
TGFATransforming growth factor alpha. (166 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (758 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
FLCNFolliculin. (515 aa)
FHFumarate hydratase. (510 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (587 aa)
TGFB1Transforming growth factor beta 1. (226 aa)
BADBCL2 associated agonist of cell death. (167 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (389 aa)
CUL2Cullin 2; Belongs to the cullin family. (758 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
CRKCRK proto-oncogene, adaptor protein. (245 aa)
ENSMLEP00000004779Uncharacterized protein. (139 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1403 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (656 aa)
ERASES cell expressed Ras. (233 aa)
PAK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (477 aa)
LOC105530991Uncharacterized protein. (185 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
ENSMLEP00000015363Uncharacterized protein. (66 aa)
CREBBPCREB binding protein. (2423 aa)
ENSMLEP00000018399Uncharacterized protein. (153 aa)
ENSMLEP00000018677Uncharacterized protein. (185 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
LOC105537007Ubiquitin-like domain-containing protein. (103 aa)
ENSMLEP00000012128Uncharacterized protein. (234 aa)
ENSMLEP00000012301Protein kinase domain-containing protein. (294 aa)
EGLN1Fe2OG dioxygenase domain-containing protein. (128 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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