STRINGSTRING
KRAS KRAS ENSMLEP00000040499 ENSMLEP00000040499 CTNNA1 CTNNA1 CTNNA2 CTNNA2 POLK POLK TP53 TP53 AKT3 AKT3 HRAS HRAS CASP9 CASP9 ENSMLEP00000035176 ENSMLEP00000035176 CDH1 CDH1 BRAF BRAF PIK3R1 PIK3R1 APC APC ENSMLEP00000033047 ENSMLEP00000033047 PIK3R3 PIK3R3 PPP1R14B PPP1R14B NRAS NRAS CSDE1 CSDE1 PIK3CB PIK3CB AKT1 AKT1 TCF7 TCF7 PIK3CD PIK3CD ARAF ARAF PTEN PTEN ENSMLEP00000024805 ENSMLEP00000024805 GSK3B GSK3B APC2 APC2 EGFR EGFR GADD45B GADD45B MAPK1 MAPK1 FOXO3 FOXO3 SOS2 SOS2 AKT2 AKT2 SOS1 SOS1 MAPK3 MAPK3 TCF7L1 TCF7L1 MAP2K1 MAP2K1 PIK3CA PIK3CA GADD45A GADD45A BAK1 BAK1 GRB2 GRB2 MYC MYC DDB2 DDB2 ERBB2 ERBB2 ILK ILK AXIN1 AXIN1 TCF7L2 TCF7L2 ENSMLEP00000015528 ENSMLEP00000015528 MAP2K2 MAP2K2 GADD45G GADD45G LOC105532771 LOC105532771 TPTE2 TPTE2 ENSMLEP00000012301 ENSMLEP00000012301 PDPK1 PDPK1 CDKN1A CDKN1A RAF1 RAF1 MLH1 MLH1 AXIN2 AXIN2 ENSMLEP00000009356 ENSMLEP00000009356 CTNNB1 CTNNB1 ELK1 ELK1 ERAS ERAS LEF1 LEF1 EGF EGF BAX BAX BAD BAD PIK3R2 PIK3R2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRASKRAS proto-oncogene, GTPase. (189 aa)
ENSMLEP00000040499Uncharacterized protein. (147 aa)
CTNNA1Catenin alpha 1. (906 aa)
CTNNA2Catenin alpha 2. (953 aa)
POLKDNA polymerase kappa. (870 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (400 aa)
ENSMLEP00000035176Uncharacterized protein. (77 aa)
CDH1Cadherin 1. (628 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
APCAPC regulator of WNT signaling pathway. (2806 aa)
ENSMLEP00000033047Uncharacterized protein. (67 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PPP1R14BUncharacterized protein. (127 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CSDE1Cold shock domain containing E1. (844 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
TCF7Transcription factor 7. (269 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (604 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
APC2APC regulator of WNT signaling pathway 2. (1668 aa)
EGFRReceptor protein-tyrosine kinase. (1188 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (176 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
FOXO3Forkhead box O3. (670 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1317 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1299 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
TCF7L1Transcription factor 7 like 1. (432 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
ILKIntegrin linked kinase. (512 aa)
AXIN1Axin 1. (859 aa)
TCF7L2Transcription factor 7 like 2. (555 aa)
ENSMLEP00000015528Uncharacterized protein. (184 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (389 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
LOC105532771Uncharacterized protein. (665 aa)
TPTE2Uncharacterized protein. (550 aa)
ENSMLEP00000012301Protein kinase domain-containing protein. (294 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (529 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MLH1MutL homolog 1. (756 aa)
AXIN2Axin 2. (843 aa)
ENSMLEP00000009356Uncharacterized protein. (168 aa)
CTNNB1Catenin beta 1. (781 aa)
ELK1ETS transcription factor ELK1. (428 aa)
ERASES cell expressed Ras. (233 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1152 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
BADBCL2 associated agonist of cell death. (167 aa)
PIK3R2Uncharacterized protein. (587 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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