STRINGSTRING
PRKCG PRKCG PRKCB PRKCB IGF1R IGF1R EGFR EGFR PLCG2 PLCG2 E2F3 E2F3 GADD45B GADD45B MAPK1 MAPK1 CAMK4 CAMK4 SOS2 SOS2 AKT2 AKT2 RB1 RB1 SOS1 SOS1 MAPK3 MAPK3 PRKCA PRKCA CALML4 CALML4 MAP2K1 MAP2K1 PIK3CA PIK3CA CALM2 CALM2 GADD45A GADD45A BAK1 BAK1 PVALEF PVALEF CDKN2A CDKN2A GRB2 GRB2 DDB2 DDB2 TGFA TGFA ENSMLEP00000015528 ENSMLEP00000015528 MAP2K2 MAP2K2 GADD45G GADD45G E2F2 E2F2 SHC4 SHC4 TPTE2 TPTE2 ENSMLEP00000012301 ENSMLEP00000012301 CDKN1A CDKN1A RAF1 RAF1 PDGFRA PDGFRA CALM1 CALM1 KRAS KRAS CAMK2G CAMK2G CAMK2B CAMK2B ERAS ERAS EGF EGF IGF1 IGF1 MTOR MTOR PDGFRB PDGFRB CALML3 CALML3 BAX BAX LOC105540811 LOC105540811 ENSMLEP00000002165 ENSMLEP00000002165 PIK3R2 PIK3R2 E2F1 E2F1 SHC3 SHC3 CAMK1D CAMK1D CEP152 CEP152 CAMK2D CAMK2D ENSMLEP00000033047 ENSMLEP00000033047 CAMK2A CAMK2A PIK3R3 PIK3R3 PDGFB PDGFB ARSI ARSI NRAS NRAS PDGFA PDGFA CSDE1 CSDE1 PLCG1 PLCG1 PIK3CB PIK3CB CALM3 CALM3 AKT1 AKT1 ENSMLEP00000027485 ENSMLEP00000027485 CDK4 CDK4 PIK3CD PIK3CD ARAF ARAF CDK6 CDK6 PTEN PTEN ENSMLEP00000024805 ENSMLEP00000024805 CALML6 CALML6 ENSMLEP00000038520 ENSMLEP00000038520 POLK POLK TP53 TP53 AKT3 AKT3 CAMK1G CAMK1G SHC2 SHC2 MDM2 MDM2 HRAS HRAS SHC1 SHC1 ENSMLEP00000035176 ENSMLEP00000035176 BRAF BRAF CAMK1 CAMK1 PIK3R1 PIK3R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCGProtein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (558 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
IGF1RTyrosine-protein kinase receptor. (1281 aa)
EGFRReceptor protein-tyrosine kinase. (1188 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1221 aa)
E2F3E2F transcription factor 3. (375 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (176 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1317 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RB1RB transcriptional corepressor 1. (891 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1299 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
CALML4Calmodulin like 4. (193 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CALM2Calmodulin 2. (149 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
TGFATransforming growth factor alpha. (166 aa)
ENSMLEP00000015528Uncharacterized protein. (184 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (389 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
E2F2E2F transcription factor 2. (437 aa)
SHC4SHC adaptor protein 4. (630 aa)
TPTE2Uncharacterized protein. (550 aa)
ENSMLEP00000012301Protein kinase domain-containing protein. (294 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (546 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (689 aa)
ERASES cell expressed Ras. (233 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1152 aa)
IGF1Insulin like growth factor 1. (159 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
LOC105540811Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
ENSMLEP00000002165Uncharacterized protein; Belongs to the calmodulin family. (95 aa)
PIK3R2Uncharacterized protein. (587 aa)
E2F1E2F transcription factor 1. (381 aa)
SHC3SHC adaptor protein 3. (444 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (354 aa)
CEP152Centrosomal protein 152. (1709 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (441 aa)
ENSMLEP00000033047Uncharacterized protein. (67 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ARSIArylsulfatase family member I. (568 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (287 aa)
CSDE1Cold shock domain containing E1. (844 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1276 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
CALM3Calmodulin 3. (149 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
ENSMLEP00000027485PID domain-containing protein. (488 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (604 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
CALML6Calmodulin like 6. (181 aa)
ENSMLEP00000038520Uncharacterized protein; Belongs to the calmodulin family. (91 aa)
POLKDNA polymerase kappa. (870 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
SHC2Uncharacterized protein. (483 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SHC1SHC adaptor protein 1. (584 aa)
ENSMLEP00000035176Uncharacterized protein. (77 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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