STRINGSTRING
LAMB3 LAMB3 PTGS2 PTGS2 LAMB4 LAMB4 LAMB1 LAMB1 ENSMLEP00000038171 ENSMLEP00000038171 COL4A2 COL4A2 TRAF2 TRAF2 POLK POLK TP53 TP53 AKT3 AKT3 MAX MAX CASP9 CASP9 RELA RELA ENSMLEP00000035176 ENSMLEP00000035176 BIRC3 BIRC3 PIK3R1 PIK3R1 XIAP XIAP TRAF5 TRAF5 COL4A5 COL4A5 ENSMLEP00000033047 ENSMLEP00000033047 LAMC1 LAMC1 LAMA4 LAMA4 COL4A1 COL4A1 PIK3R3 PIK3R3 CCNE1 CCNE1 LAMC2 LAMC2 ITGA6 ITGA6 COL4A6 COL4A6 LAMA3 LAMA3 ITGB1 ITGB1 TRAF4 TRAF4 PIK3CB PIK3CB AKT1 AKT1 NOS2 NOS2 FN1 FN1 CDKN2B CDKN2B CDK4 CDK4 NFKBIA NFKBIA PIK3CD PIK3CD CDK6 CDK6 PTEN PTEN ENSMLEP00000025412 ENSMLEP00000025412 C7orf31 C7orf31 LAMA1 LAMA1 LAMA5 LAMA5 COL4A4 COL4A4 SKP2 SKP2 APAF1 APAF1 TRAF1 TRAF1 E2F3 E2F3 GADD45B GADD45B CHUK CHUK CKS2 CKS2 BIRC2 BIRC2 ITGA2B ITGA2B AKT2 AKT2 LAMC3 LAMC3 RB1 RB1 RARB RARB PIK3CA PIK3CA ZBTB17 ZBTB17 CDK2 CDK2 LOC105553918 LOC105553918 E2F1 E2F1 LOC105536632 LOC105536632 LOC105553485 LOC105553485 PIK3R2 PIK3R2 BIRC7 BIRC7 TRAF6 TRAF6 BAX BAX ITGA2 ITGA2 ITGAV ITGAV COL4A3 COL4A3 BCL2 BCL2 LOC105533249 LOC105533249 RXRG RXRG ENSMLEP00000006706 ENSMLEP00000006706 LAMA2 LAMA2 ENSMLEP00000007765 ENSMLEP00000007765 CASP3 CASP3 SECISBP2 SECISBP2 RXRA RXRA CDKN1B CDKN1B CDKN1A CDKN1A RXRB RXRB CKS1B CKS1B ITGA3 ITGA3 LOC105552669 LOC105552669 NFKB1 NFKB1 MFF MFF TPTE2 TPTE2 CCNE2 CCNE2 E2F2 E2F2 PTK2 PTK2 GADD45G GADD45G ENSMLEP00000015528 ENSMLEP00000015528 FHIT FHIT IKBKG IKBKG DDB2 DDB2 ENSMLEP00000017044 ENSMLEP00000017044 IKBKB IKBKB MYC MYC TRAF3 TRAF3 BCL2L1 BCL2L1 BAK1 BAK1 GADD45A GADD45A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LAMB3Laminin subunit beta 3. (1172 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
LAMB4Laminin subunit beta 4. (1729 aa)
LAMB1Laminin subunit beta 1. (1786 aa)
ENSMLEP00000038171Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (66 aa)
COL4A2Collagen type IV alpha 2 chain. (1673 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
POLKDNA polymerase kappa. (870 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAXMYC associated factor X. (160 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (400 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
ENSMLEP00000035176Uncharacterized protein. (77 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
XIAPX-linked inhibitor of apoptosis. (484 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
COL4A5Collagen type IV alpha 5 chain. (1661 aa)
ENSMLEP00000033047Uncharacterized protein. (67 aa)
LAMC1Laminin subunit gamma 1. (1575 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
COL4A1Collagen type IV alpha 1 chain. (1641 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (407 aa)
LAMC2Laminin subunit gamma 2. (1193 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1069 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (748 aa)
TRAF4TNF receptor-associated factor. (422 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1147 aa)
FN1Fibronectin 1. (2384 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (157 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
NFKBIAANK_REP_REGION domain-containing protein. (305 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ENSMLEP00000025412Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (69 aa)
C7orf31Chromosome 7 open reading frame 31. (590 aa)
LAMA1Laminin subunit alpha 1. (3008 aa)
LAMA5Laminin subunit alpha 5. (3494 aa)
COL4A4Collagen type IV alpha 4 chain. (1692 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
TRAF1TNF receptor-associated factor. (416 aa)
E2F3E2F transcription factor 3. (375 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (176 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LAMC3Laminin subunit gamma 3. (1423 aa)
RB1RB transcriptional corepressor 1. (891 aa)
RARBRetinoic acid receptor beta. (448 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ZBTB17Zinc finger and BTB domain containing 17. (807 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
LOC105553918Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
E2F1E2F transcription factor 1. (381 aa)
LOC105536632Uncharacterized protein. (598 aa)
LOC105553485Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PIK3R2Uncharacterized protein. (587 aa)
BIRC7Baculoviral IAP repeat containing 7. (297 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1152 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
COL4A3Collagen type IV alpha 3 chain. (1635 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
LOC105533249Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
RXRGRetinoid X receptor gamma. (463 aa)
ENSMLEP00000006706Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (96 aa)
LAMA2Laminin subunit alpha 2. (2528 aa)
ENSMLEP00000007765Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
SECISBP2SECIS binding protein 2. (788 aa)
RXRARetinoid X receptor alpha. (452 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
RXRBRetinoid X receptor beta. (537 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
LOC105552669Uncharacterized protein; Belongs to the peptidase C14A family. (215 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
MFFMitochondrial fission factor. (342 aa)
TPTE2Uncharacterized protein. (550 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
E2F2E2F transcription factor 2. (437 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
ENSMLEP00000015528Uncharacterized protein. (184 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (396 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
ENSMLEP00000017044Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (86 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (706 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
BCL2L1BCL2 like 1. (233 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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