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PIP5K1A PIP5K1A HIF1A HIF1A WAS WAS GRB2 GRB2 LOC105530438 LOC105530438 RAC2 RAC2 PIK3CA PIK3CA MAP2K1 MAP2K1 PRKCA PRKCA MAPK3 MAPK3 SOS1 SOS1 ENSMLEP00000021624 ENSMLEP00000021624 AKT2 AKT2 SOS2 SOS2 DGKI DGKI PLA2G4C PLA2G4C SLC44A1 SLC44A1 MAPK1 MAPK1 SLC44A3 SLC44A3 EGFR EGFR PLD1 PLD1 PRKCG PRKCG ENSMLEP00000024805 ENSMLEP00000024805 LOC105533469 LOC105533469 TSC1 TSC1 DGKE DGKE PCYT1A PCYT1A PIK3CD PIK3CD PLD2 PLD2 PDGFC PDGFC AKT1 AKT1 PIK3CB PIK3CB LOC105540582 LOC105540582 SLC44A5 SLC44A5 PLCG1 PLCG1 JMJD7 JMJD7 SLC22A3 SLC22A3 CSDE1 CSDE1 PDGFA PDGFA TSC2 TSC2 NRAS NRAS PLA2G4B PLA2G4B PDGFB PDGFB PRKCB PRKCB RAC1 RAC1 ENSMLEP00000001022 ENSMLEP00000001022 PIK3R2 PIK3R2 PLA2G4E PLA2G4E RALGDS RALGDS PLA2G4F PLA2G4F SLC44A4 SLC44A4 SLC22A2 SLC22A2 WASF1 WASF1 DGKH DGKH DGKA DGKA PDGFRB PDGFRB DGKQ DGKQ MTOR MTOR DGKB DGKB EGF EGF CHPT1 CHPT1 MAPK10 MAPK10 DGKZ DGKZ ERAS ERAS RPS6KB1 RPS6KB1 MAPK9 MAPK9 KRAS KRAS PDGFD PDGFD LYPLA1 LYPLA1 PLPP3 PLPP3 RPS6KB2 RPS6KB2 RHEB RHEB PLPP1 PLPP1 PDGFRA PDGFRA ENSMLEP00000011041 ENSMLEP00000011041 RAF1 RAF1 SLC22A4 SLC22A4 PDPK1 PDPK1 PIP5K1B PIP5K1B PCYT1B PCYT1B ENSMLEP00000014023 ENSMLEP00000014023 DGKG DGKG PLA2G4A PLA2G4A PIP5K1C PIP5K1C LOC105552366 LOC105552366 LOC105549769 LOC105549769 MAP2K2 MAP2K2 DGKK DGKK SLC44A2 SLC44A2 PLA2G4D PLA2G4D RAC3 RAC3 SLC5A7 SLC5A7 DGKD DGKD RGL4 RGL4 CHKA CHKA RHEBL1 RHEBL1 SLC22A1 SLC22A1 GPCPD1 GPCPD1 PLPP2 PLPP2 SP1 SP1 AKT3 AKT3 HRAS HRAS WASF2 WASF2 PIK3R1 PIK3R1 CHKB CHKB FOS FOS SLC22A5 SLC22A5 WASF3 WASF3 ENSMLEP00000031455 ENSMLEP00000031455 LOC105548563 LOC105548563 PIK3R3 PIK3R3 EIF4EBP1 EIF4EBP1 MAPK8 MAPK8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (493 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (758 aa)
WASWASP actin nucleation promoting factor. (503 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
LOC105530438Ras-GEF domain-containing protein. (560 aa)
RAC2Rac family small GTPase 2. (192 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1299 aa)
ENSMLEP00000021624PIPK domain-containing protein. (457 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1317 aa)
DGKIDiacylglycerol kinase. (937 aa)
PLA2G4CPhospholipase A2 group IVC. (469 aa)
SLC44A1Solute carrier family 44 member 1; Belongs to the CTL (choline transporter-like) family. (702 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
SLC44A3Solute carrier family 44 member 3; Belongs to the CTL (choline transporter-like) family. (653 aa)
EGFRReceptor protein-tyrosine kinase. (1188 aa)
PLD1Phospholipase. (1074 aa)
PRKCGProtein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (558 aa)
ENSMLEP00000024805Protein kinase domain-containing protein. (365 aa)
LOC105533469Ras-GEF domain-containing protein. (540 aa)
TSC1TSC complex subunit 1. (1162 aa)
DGKEDiacylglycerol kinase. (567 aa)
PCYT1APhosphate cytidylyltransferase 1, choline, alpha. (380 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PLD2Phospholipase. (933 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
LOC105540582Ras-GEF domain-containing protein. (407 aa)
SLC44A5Solute carrier family 44 member 5; Belongs to the CTL (choline transporter-like) family. (719 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1276 aa)
JMJD7Jumonji domain containing 7. (316 aa)
SLC22A3Solute carrier family 22 member 3. (492 aa)
CSDE1Cold shock domain containing E1. (844 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (287 aa)
TSC2TSC complex subunit 2. (1807 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PLA2G4BPhospholipase A2. (781 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
RAC1Uncharacterized protein. (280 aa)
ENSMLEP00000001022Uncharacterized protein. (189 aa)
PIK3R2Uncharacterized protein. (587 aa)
PLA2G4EPhospholipase A2. (869 aa)
RALGDSUncharacterized protein. (911 aa)
PLA2G4FPhospholipase A2. (849 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (672 aa)
SLC22A2Solute carrier family 22 member 2. (555 aa)
WASF1WASP family member 1. (559 aa)
DGKHDiacylglycerol kinase. (1156 aa)
DGKADiacylglycerol kinase. (735 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
DGKQDiacylglycerol kinase. (778 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
DGKBDiacylglycerol kinase. (763 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1152 aa)
CHPT1Choline phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (399 aa)
MAPK10Mitogen-activated protein kinase. (477 aa)
DGKZDiacylglycerol kinase. (1120 aa)
ERASES cell expressed Ras. (233 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAPK9Mitogen-activated protein kinase. (395 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PDGFDPlatelet derived growth factor D. (353 aa)
LYPLA1Lysophospholipase 1. (191 aa)
PLPP3acidPPc domain-containing protein. (311 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
RHEBRas homolog, mTORC1 binding. (181 aa)
PLPP1Phospholipid phosphatase 1. (313 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
ENSMLEP00000011041Abhydrolase_2 domain-containing protein. (158 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
SLC22A4Solute carrier family 22 member 4. (551 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (529 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (575 aa)
PCYT1BPhosphate cytidylyltransferase 1, choline, beta. (369 aa)
ENSMLEP00000014023Ras-GEF domain-containing protein. (387 aa)
DGKGDiacylglycerol kinase. (791 aa)
PLA2G4APhospholipase A2. (749 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (669 aa)
LOC105552366Ras-GEF domain-containing protein. (600 aa)
LOC105549769Uncharacterized protein. (182 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (389 aa)
DGKKDiacylglycerol kinase. (1273 aa)
SLC44A2Solute carrier family 44 member 2; Belongs to the CTL (choline transporter-like) family. (658 aa)
PLA2G4DPhospholipase A2. (817 aa)
RAC3Rac family small GTPase 3. (212 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
DGKDDiacylglycerol kinase. (1181 aa)
RGL4Ras-GEF domain-containing protein. (591 aa)
CHKACholine kinase alpha. (410 aa)
RHEBL1RHEB like 1. (183 aa)
SLC22A1Solute carrier family 22 member 1. (552 aa)
GPCPD1Glycerophosphocholine phosphodiesterase 1. (672 aa)
PLPP2Phospholipid phosphatase 2. (285 aa)
SP1Uncharacterized protein. (661 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
WASF2WASP family member 2. (498 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CHKBCholine kinase beta. (337 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SLC22A5Solute carrier family 22 member 5. (455 aa)
WASF3WASP family member 3. (502 aa)
ENSMLEP00000031455PIPK domain-containing protein. (487 aa)
LOC105548563Uncharacterized protein. (245 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (73 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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