STRINGSTRING
ACTRT2 ACTRT2 CALML6 CALML6 RAC3 RAC3 MAP3K5 MAP3K5 LOC105552459 LOC105552459 SELE SELE ENSMLEP00000039277 ENSMLEP00000039277 BMP4 BMP4 ENSMLEP00000038520 ENSMLEP00000038520 MAPK14 MAPK14 GSTA1 GSTA1 NOXA1 NOXA1 ENSMLEP00000037519 ENSMLEP00000037519 GSTO1 GSTO1 ENSMLEP00000037330 ENSMLEP00000037330 NFE2L2 NFE2L2 TP53 TP53 AKT3 AKT3 ACTG1 ACTG1 ENSMLEP00000036527 ENSMLEP00000036527 GSTA4 GSTA4 RELA RELA SRC SRC MMP9 MMP9 TNFRSF1A TNFRSF1A GSTM3 GSTM3 PRKAA1 PRKAA1 NCF2 NCF2 SUMO3 SUMO3 IL1R2 IL1R2 PIK3R1 PIK3R1 MEF2A MEF2A MAP2K4 MAP2K4 CALM3 CALM3 CAV2 CAV2 HSP90AA1 HSP90AA1 MAPK13 MAPK13 FOS FOS ENSMLEP00000032494 ENSMLEP00000032494 SDC2 SDC2 MGST2 MGST2 PIK3R3 PIK3R3 PDGFB PDGFB MAP3K7 MAP3K7 ENSMLEP00000030622 ENSMLEP00000030622 ASS1 ASS1 PDGFA PDGFA GSTO2 GSTO2 DUSP1 DUSP1 NQO1 NQO1 KDR KDR MGST3 MGST3 ACTB ACTB ARHGEF2 ARHGEF2 VEGFA VEGFA MMP2 MMP2 RHOA RHOA PIK3CB PIK3CB AKT1 AKT1 LOC105542545 LOC105542545 ENSMLEP00000027278 ENSMLEP00000027278 ENSMLEP00000027272 ENSMLEP00000027272 MAPK12 MAPK12 GSTM2 GSTM2 ENSMLEP00000027131 ENSMLEP00000027131 SQSTM1 SQSTM1 ACVR1 ACVR1 NOX1 NOX1 GSTA3 GSTA3 PIK3CD PIK3CD VCAM1 VCAM1 ENSMLEP00000025658 ENSMLEP00000025658 GSTA5 GSTA5 CTSL CTSL KEAP1 KEAP1 PIAS4 PIAS4 IL1B IL1B LOC105538379 LOC105538379 LOC105544325 LOC105544325 NCF1 NCF1 GSTT2B GSTT2B TRPV4 TRPV4 ENSMLEP00000023425 ENSMLEP00000023425 CHUK CHUK ENSMLEP00000023200 ENSMLEP00000023200 MAPK11 MAPK11 MEF2C MEF2C ITGA2B ITGA2B IFNG IFNG AKT2 AKT2 BMPR1A BMPR1A ICAM1 ICAM1 CALML4 CALML4 SUMO1 SUMO1 CAV3 CAV3 LOC105540399 LOC105540399 PIK3CA PIK3CA CALM2 CALM2 PTTG1IP PTTG1IP CCL2 CCL2 GPC1 GPC1 BMPR1B BMPR1B RAC2 RAC2 PVALEF PVALEF MAP2K5 MAP2K5 HMOX1 HMOX1 SDC4 SDC4 IKBKB IKBKB PECAM1 PECAM1 IL1R1 IL1R1 LOC105534642 LOC105534642 PRKCZ PRKCZ IKBKG IKBKG TXNDC2 TXNDC2 LOC105530428 LOC105530428 ENSMLEP00000015948 ENSMLEP00000015948 ENSMLEP00000015845 ENSMLEP00000015845 MAP2K7 MAP2K7 MAPK8 MAPK8 IL1A IL1A ITGB3 ITGB3 PTK2 PTK2 LOC105549769 LOC105549769 ENSMLEP00000014709 ENSMLEP00000014709 MAP2K6 MAP2K6 CYBA CYBA NOS3 NOS3 ENSMLEP00000013375 ENSMLEP00000013375 ENSMLEP00000012897 ENSMLEP00000012897 NFKB1 NFKB1 SDC1 SDC1 TXNDC8 TXNDC8 ENSMLEP00000011647 ENSMLEP00000011647 LOC105553882 LOC105553882 LOC105531803 LOC105531803 ENSMLEP00000011359 ENSMLEP00000011359 CALM1 CALM1 TXN TXN ACVR2B ACVR2B ACVR2A ACVR2A CAV1 CAV1 CTNNB1 CTNNB1 LOC105532451 LOC105532451 MAPK7 MAPK7 ENSMLEP00000008036 ENSMLEP00000008036 CDH5 CDH5 MAPK9 MAPK9 GSTA2 GSTA2 MGST1 MGST1 ACTL7A ACTL7A MAPK10 MAPK10 ACTRT1 ACTRT1 BCL2 BCL2 LOC105552923 LOC105552923 HSP90AB1 HSP90AB1 ENSMLEP00000005277 ENSMLEP00000005277 RHOC RHOC ENSMLEP00000005144 ENSMLEP00000005144 HSP90B1 HSP90B1 ITGAV ITGAV EDN1 EDN1 PLAT PLAT CALML3 CALML3 LOC105540811 LOC105540811 PRKAA2 PRKAA2 NPPC NPPC ENSMLEP00000002165 ENSMLEP00000002165 ACTL7B ACTL7B GSTP1 GSTP1 PIK3R2 PIK3R2 BMPR2 BMPR2 ENSMLEP00000001022 ENSMLEP00000001022 ENSMLEP00000000876 ENSMLEP00000000876 RAC1 RAC1 LOC105554720 LOC105554720 ACTL8 ACTL8 GSTM5 GSTM5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTRT2Actin related protein T2; Belongs to the actin family. (377 aa)
CALML6Calmodulin like 6. (181 aa)
RAC3Rac family small GTPase 3. (212 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1306 aa)
LOC105552459Uncharacterized protein. (163 aa)
SELESelectin E. (610 aa)
ENSMLEP00000039277annotation not available (67 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ENSMLEP00000038520Uncharacterized protein; Belongs to the calmodulin family. (91 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
GSTA1Glutathione S-transferase alpha 1. (222 aa)
NOXA1NADPH oxidase activator 1. (442 aa)
ENSMLEP00000037519Uncharacterized protein. (87 aa)
GSTO1Glutathione S-transferase omega 1. (241 aa)
ENSMLEP00000037330Small ubiquitin-related modifier. (103 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (596 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ACTG1Actin gamma 1. (376 aa)
ENSMLEP00000036527Uncharacterized protein. (89 aa)
GSTA4Glutathione S-transferase alpha 4. (222 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
SRCTyrosine-protein kinase. (542 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
GSTM3Glutathione S-transferase. (210 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
SUMO3Ubiquitin-like domain-containing protein. (189 aa)
IL1R2Interleukin 1 receptor type 2. (398 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MEF2AMyocyte enhancer factor 2A. (513 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (373 aa)
CALM3Calmodulin 3. (149 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (140 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (823 aa)
MAPK13Mitogen-activated protein kinase. (397 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ENSMLEP00000032494Thioredoxin; Belongs to the thioredoxin family. (101 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ENSMLEP00000030622Small ubiquitin-related modifier. (81 aa)
ASS1Uncharacterized protein. (412 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (287 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (274 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
MGST3Uncharacterized protein. (154 aa)
ACTBActin beta. (375 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (996 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (210 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
RHOARas homolog family member A. (193 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
LOC105542545HATPase_c domain-containing protein. (626 aa)
ENSMLEP00000027278Uncharacterized protein. (294 aa)
ENSMLEP00000027272Uncharacterized protein. (424 aa)
MAPK12Mitogen-activated protein kinase. (292 aa)
GSTM2Glutathione S-transferase. (221 aa)
ENSMLEP00000027131Uncharacterized protein. (130 aa)
SQSTM1Sequestosome 1. (374 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
NOX1NADPH oxidase 1. (564 aa)
GSTA3Glutathione S-transferase alpha 3. (222 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
ENSMLEP00000025658Uncharacterized protein. (432 aa)
GSTA5Glutathione S-transferase alpha 5. (222 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
PIAS4Protein inhibitor of activated STAT 4. (510 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
LOC105538379HATPase_c domain-containing protein. (673 aa)
LOC105544325Thioredoxin; Belongs to the thioredoxin family. (101 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
GSTT2BUncharacterized protein; Belongs to the GST superfamily. (244 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
ENSMLEP00000023425Uncharacterized protein. (442 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ENSMLEP00000023200Uncharacterized protein. (366 aa)
MAPK11Mitogen-activated protein kinase. (224 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
CALML4Calmodulin like 4. (193 aa)
SUMO1Ubiquitin-like domain-containing protein. (62 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
LOC105540399Uncharacterized protein; Belongs to the actin family. (362 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CALM2Calmodulin 2. (149 aa)
PTTG1IPPTTG1 interacting protein. (159 aa)
CCL2C-C motif chemokine. (99 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (508 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
RAC2Rac family small GTPase 2. (192 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
HMOX1Heme oxygenase 1. (311 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (706 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (625 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
LOC105534642Uncharacterized protein. (401 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (396 aa)
TXNDC2Thioredoxin domain containing 2. (448 aa)
LOC105530428Uncharacterized protein. (240 aa)
ENSMLEP00000015948Uncharacterized protein. (90 aa)
ENSMLEP00000015845Rad60-SLD domain-containing protein. (78 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (442 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
LOC105549769Uncharacterized protein. (182 aa)
ENSMLEP00000014709Thioredoxin domain-containing protein. (161 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa)
CYBACytochrome b-245 alpha chain. (194 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1155 aa)
ENSMLEP00000013375Small ubiquitin-related modifier. (100 aa)
ENSMLEP00000012897Uncharacterized protein. (303 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (332 aa)
TXNDC8Thioredoxin domain containing 8. (127 aa)
ENSMLEP00000011647GST N-terminal domain-containing protein. (67 aa)
LOC105553882Uncharacterized protein. (356 aa)
LOC105531803Uncharacterized protein. (734 aa)
ENSMLEP00000011359Uncharacterized protein. (384 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
TXNThioredoxin domain-containing protein. (83 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
CTNNB1Catenin beta 1. (781 aa)
LOC105532451Glutathione S-transferase. (190 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
ENSMLEP00000008036Thioredoxin domain-containing protein. (64 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (705 aa)
MAPK9Mitogen-activated protein kinase. (395 aa)
GSTA2Glutathione S-transferase alpha 2; Belongs to the GST superfamily. (222 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
ACTL7AActin like 7A; Belongs to the actin family. (435 aa)
MAPK10Mitogen-activated protein kinase. (477 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (375 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
LOC105552923Small ubiquitin-related modifier. (95 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
ENSMLEP00000005277Small ubiquitin-related modifier. (103 aa)
RHOCRas homolog family member C. (193 aa)
ENSMLEP00000005144Thioredoxin; Belongs to the thioredoxin family. (105 aa)
HSP90B1Heat shock protein 90 beta family member 1. (804 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
EDN1Endothelin 1. (211 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
LOC105540811Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
NPPCNatriuretic peptide C. (126 aa)
ENSMLEP00000002165Uncharacterized protein; Belongs to the calmodulin family. (95 aa)
ACTL7BActin like 7B; Belongs to the actin family. (415 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
PIK3R2Uncharacterized protein. (587 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1032 aa)
ENSMLEP00000001022Uncharacterized protein. (189 aa)
ENSMLEP00000000876Ubiquitin-like domain-containing protein. (132 aa)
RAC1Uncharacterized protein. (280 aa)
LOC105554720HATPase_c domain-containing protein. (658 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
GSTM5Glutathione S-transferase. (198 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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