STRINGSTRING
MARCHF4 MARCHF4 LATS1 LATS1 NPTN NPTN BCL2 BCL2 FLT3 FLT3 SASS6 SASS6 CSF2 CSF2 IL3 IL3 CST7 CST7 G3QGN8_GORGO G3QGN8_GORGO ETV6 ETV6 CNTN6 CNTN6 RARA RARA RDH5 RDH5 CD4 CD4 NUDT2 NUDT2 KLF3 KLF3 RBL1 RBL1 PBX4 PBX4 G3QT76_GORGO G3QT76_GORGO IFNG IFNG IL1B IL1B FCER2 FCER2 G3QVY2_GORGO G3QVY2_GORGO TFRC TFRC G3QY87_GORGO G3QY87_GORGO MLN MLN HSP90AB1 HSP90AB1 TOP1 TOP1 NFKBIA NFKBIA MOB2 MOB2 G3R4C9_GORGO G3R4C9_GORGO MPL MPL ABL1 ABL1 MCOLN1 MCOLN1 MLX MLX TNFSF11 TNFSF11 PBX1 PBX1 TXNIP TXNIP E2F4 E2F4 G3R8R1_GORGO G3R8R1_GORGO CASP10 CASP10 ACP5 ACP5 ITGA2B ITGA2B G3RDK5_GORGO G3RDK5_GORGO IL10 IL10 SAV1 SAV1 CITED2 CITED2 CD19 CD19 G3RLK9_GORGO G3RLK9_GORGO NUP214 NUP214 TNFSF13B TNFSF13B MPRIP MPRIP AFF1 AFF1 PTGS2 PTGS2 G3RQE7_GORGO G3RQE7_GORGO CD247 CD247 SDHAF2 SDHAF2 IL6 IL6 MYC MYC GATA1 GATA1 EPOR EPOR G3RV30_GORGO G3RV30_GORGO G3RVP8_GORGO G3RVP8_GORGO G3RWF8_GORGO G3RWF8_GORGO TLR4 TLR4 ENSGGOP00000021036 ENSGGOP00000021036 CASP3 CASP3 PRAM1 PRAM1 ATP7A ATP7A IL2 IL2 G3S2I0_GORGO G3S2I0_GORGO G3S334_GORGO G3S334_GORGO NANOGP8 NANOGP8 G3S4Z2_GORGO G3S4Z2_GORGO G3S8N2_GORGO G3S8N2_GORGO CD34 CD34 G3S971_GORGO G3S971_GORGO G3S9E3_GORGO G3S9E3_GORGO G3S9P8_GORGO G3S9P8_GORGO G3SAG0_GORGO G3SAG0_GORGO G3SBY7_GORGO G3SBY7_GORGO G3SDM2_GORGO G3SDM2_GORGO FGFR1OP2 FGFR1OP2 G3SEN9_GORGO G3SEN9_GORGO G3SEU0_GORGO G3SEU0_GORGO G3SJ95_GORGO G3SJ95_GORGO FIP1L1 FIP1L1 CYCS CYCS ENSGGOP00000028943 ENSGGOP00000028943 ENSGGOP00000030478 ENSGGOP00000030478 ENSGGOP00000031121 ENSGGOP00000031121 CD28 CD28 ENSGGOP00000031996 ENSGGOP00000031996 LCK LCK NCAM1 NCAM1 DERL2 DERL2 NUP88 NUP88 AR AR SIT1 SIT1 RUNX1 RUNX1 OGA OGA ENSGGOP00000036074 ENSGGOP00000036074 ENSGGOP00000036146 ENSGGOP00000036146 ENSGGOP00000036169 ENSGGOP00000036169 PTK7 PTK7 TPT1 TPT1 ANXA5 ANXA5 NPM1 NPM1 ATR ATR LRRC74A LRRC74A ENSGGOP00000039199 ENSGGOP00000039199 SETD2 SETD2 ENSGGOP00000041332 ENSGGOP00000041332 ENSGGOP00000041968 ENSGGOP00000041968 DHFR DHFR ENSGGOP00000042984 ENSGGOP00000042984 ENSGGOP00000043945 ENSGGOP00000043945 ENSGGOP00000044481 ENSGGOP00000044481 ENSGGOP00000044841 ENSGGOP00000044841 ENSGGOP00000045267 ENSGGOP00000045267 ATL2 ATL2 ENSGGOP00000046735 ENSGGOP00000046735 ENSGGOP00000046758 ENSGGOP00000046758 MOB1A MOB1A TOM1 TOM1 ENSGGOP00000049826 ENSGGOP00000049826 RUNX2 RUNX2 RBL2 RBL2 RUNX1T1 RUNX1T1 CXCR4 CXCR4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MARCHF4Membrane associated ring-CH-type finger 4. (411 aa)
LATS1Large tumor suppressor kinase 1. (1130 aa)
NPTNNeuroplastin. (367 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
SASS6SAS-6 centriolar assembly protein. (657 aa)
CSF2Colony stimulating factor 2. (144 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (152 aa)
CST7Cystatin F. (145 aa)
G3QGN8_GORGOTyrosine-protein kinase. (599 aa)
ETV6ETS variant 6. (452 aa)
CNTN6Contactin 6. (1028 aa)
RARAUncharacterized protein. (624 aa)
RDH5Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa)
CD4CD4 molecule. (458 aa)
NUDT2Nudix hydrolase 2. (147 aa)
KLF3Kruppel like factor 3. (345 aa)
RBL1RB transcriptional corepressor like 1. (1066 aa)
PBX4PBX homeobox 4. (348 aa)
G3QT76_GORGOTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
FCER2Fc fragment of IgE receptor II. (321 aa)
G3QVY2_GORGOHistocompatibility minor HB-1. (41 aa)
TFRCTransferrin receptor. (760 aa)
G3QY87_GORGOHemoglobin subunit mu; Belongs to the globin family. (141 aa)
MLNMotilin. (115 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (765 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
MOB2MOB kinase activator 2. (268 aa)
G3R4C9_GORGODeltex E3 ubiquitin ligase 1. (540 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (646 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
MCOLN1Mucolipin 1. (580 aa)
MLXMAX dimerization protein MLX. (285 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
PBX1PBX homeobox 1. (430 aa)
TXNIPThioredoxin interacting protein. (391 aa)
E2F4E2F transcription factor 4. (419 aa)
G3R8R1_GORGOCaspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (341 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (523 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
G3RDK5_GORGOHomeobox domain-containing protein. (166 aa)
IL10Interleukin 10. (178 aa)
SAV1Salvador family WW domain containing protein 1. (351 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
CD19CD19 molecule. (556 aa)
G3RLK9_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
NUP214Nucleoporin 214. (2082 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (285 aa)
MPRIPMyosin phosphatase Rho interacting protein. (1035 aa)
AFF1AF4/FMR2 family member 1. (1219 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
G3RQE7_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CD247CD247 molecule. (164 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (173 aa)
IL6Interleukin 6. (234 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
GATA1GATA binding protein 1. (413 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (508 aa)
G3RV30_GORGOUncharacterized protein. (309 aa)
G3RVP8_GORGODnaJ heat shock protein family (Hsp40) member C24. (126 aa)
G3RWF8_GORGOMLLT3 super elongation complex subunit. (569 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
ENSGGOP00000021036annotation not available (839 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
PRAM1PML-RARA regulated adaptor molecule 1. (714 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
G3S2I0_GORGOIslet cell autoantigen 1. (512 aa)
G3S334_GORGOUncharacterized protein. (251 aa)
NANOGP8Nanog homeobox retrogene P8. (305 aa)
G3S4Z2_GORGOUncharacterized protein. (119 aa)
G3S8N2_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (91 aa)
CD34CD34 molecule. (385 aa)
G3S971_GORGOBTG anti-proliferation factor 3. (296 aa)
G3S9E3_GORGOHomeobox domain-containing protein. (290 aa)
G3S9P8_GORGOUncharacterized protein. (314 aa)
G3SAG0_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
G3SBY7_GORGOLeucine rich repeat containing 74B. (392 aa)
G3SDM2_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
FGFR1OP2FGFR1 oncogene partner 2. (253 aa)
G3SEN9_GORGONucleoplasmin domain-containing protein. (215 aa)
G3SEU0_GORGOHemoglobin subunit zeta; Belongs to the globin family. (142 aa)
G3SJ95_GORGOHomeobox domain-containing protein. (282 aa)
FIP1L1Factor interacting with PAPOLA and CPSF1. (594 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
ENSGGOP00000028943TCTP domain-containing protein; Belongs to the TCTP family. (221 aa)
ENSGGOP00000030478Tyrosine-protein kinase. (1151 aa)
ENSGGOP00000031121Uncharacterized protein. (361 aa)
CD28CD28 molecule. (220 aa)
ENSGGOP00000031996Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (91 aa)
LCKTyrosine-protein kinase. (524 aa)
NCAM1Neural cell adhesion molecule 1. (884 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
NUP88Nucleoporin 88. (741 aa)
ARAndrogen receptor. (902 aa)
SIT1Signaling threshold regulating transmembrane adaptor 1. (196 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
OGAO-GlcNAcase. (948 aa)
ENSGGOP00000036074HATPase_c domain-containing protein. (596 aa)
ENSGGOP00000036146TCTP domain-containing protein; Belongs to the TCTP family. (144 aa)
ENSGGOP00000036169Uncharacterized protein. (264 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
TPT1Tumor protein, translationally-controlled 1; Belongs to the TCTP family. (197 aa)
ANXA5Annexin. (321 aa)
NPM1Nucleophosmin 1. (294 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
LRRC74ALeucine rich repeat containing 74A. (524 aa)
ENSGGOP00000039199PH domain-containing protein. (947 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2564 aa)
ENSGGOP00000041332Afadin, adherens junction formation factor. (1793 aa)
ENSGGOP00000041968TCTP domain-containing protein; Belongs to the TCTP family. (198 aa)
DHFRDihydrofolate reductase; Belongs to the dihydrofolate reductase family. (187 aa)
ENSGGOP00000042984Homeobox domain-containing protein. (245 aa)
ENSGGOP00000043945Uncharacterized protein. (292 aa)
ENSGGOP00000044481Inter-alpha-trypsin inhibitor heavy chain 4. (935 aa)
ENSGGOP00000044841HSPE1-MOB4 readthrough. (225 aa)
ENSGGOP00000045267Uncharacterized protein; Belongs to the peptidase C14A family. (342 aa)
ATL2Atlastin GTPase 2. (583 aa)
ENSGGOP00000046735Non-specific serine/threonine protein kinase. (524 aa)
ENSGGOP00000046758Caspase 1; Belongs to the peptidase C14A family. (404 aa)
MOB1AMOB kinase activator 1A. (223 aa)
TOM1Target of myb1 membrane trafficking protein; Belongs to the TOM1 family. (493 aa)
ENSGGOP00000049826Uncharacterized protein. (265 aa)
RUNX2Runt domain-containing protein. (541 aa)
RBL2RB transcriptional corepressor like 2. (1139 aa)
RUNX1T1RUNX1 partner transcriptional co-repressor 1. (663 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (423 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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