STRINGSTRING
AHNAK2 AHNAK2 CD300E CD300E ENSGGOP00000045646 ENSGGOP00000045646 TREM1 TREM1 NR1D2 NR1D2 ENSGGOP00000049973 ENSGGOP00000049973 CCR1 CCR1 CXCR4 CXCR4 NRIP1 NRIP1 IFNAR2 IFNAR2 NFATC1 NFATC1 CD8A CD8A RC3H2 RC3H2 DYNC1H1 DYNC1H1 GPR171 GPR171 G3QFQ4_GORGO G3QFQ4_GORGO CCL17 CCL17 G3QHR3_GORGO G3QHR3_GORGO DCSTAMP DCSTAMP G3QI01_GORGO G3QI01_GORGO TLR2 TLR2 CD4 CD4 CYSLTR1 CYSLTR1 CXCL1 CXCL1 IL1A IL1A CCL23 CCL23 MYD88 MYD88 ITGAM ITGAM CXCL9 CXCL9 CD27 CD27 IL13 IL13 CCL24 CCL24 FPR2 FPR2 IL4 IL4 FBP1 FBP1 NFKBIL1 NFKBIL1 G3QT76_GORGO G3QT76_GORGO IFNG IFNG FCAR FCAR G3QTT4_GORGO G3QTT4_GORGO IL1B IL1B TXN TXN G3QWR7_GORGO G3QWR7_GORGO G3QYB0_GORGO G3QYB0_GORGO CCRL2 CCRL2 OAS3 OAS3 G3R063_GORGO G3R063_GORGO CD300LD CD300LD NFKBIA NFKBIA IL17A IL17A G3R3G6_GORGO G3R3G6_GORGO C1QC C1QC VSTM1 VSTM1 G3R4Q3_GORGO G3R4Q3_GORGO CFLAR CFLAR SCO2 SCO2 TOR2A TOR2A ZNF785 ZNF785 OASL OASL LILRB4 LILRB4 G3R9N8_GORGO G3R9N8_GORGO DDI1 DDI1 G3RBD1_GORGO G3RBD1_GORGO ADAM17 ADAM17 PRCC PRCC G3RD46_GORGO G3RD46_GORGO IL10 IL10 PTK2B PTK2B CCL2 CCL2 SIGLEC1 SIGLEC1 TNFSF13B TNFSF13B LTC4S LTC4S CCR2 CCR2 TNIP3 TNIP3 APC APC G3RRK1_GORGO G3RRK1_GORGO IL6 IL6 G3RV54_GORGO G3RV54_GORGO APOB APOB ARIH1 ARIH1 STAMBP STAMBP TLR4 TLR4 NFKBIZ NFKBIZ SIRPA SIRPA ENSGGOP00000021036 ENSGGOP00000021036 PPBP PPBP STAMBPL1 STAMBPL1 IL2 IL2 CEACAM1 CEACAM1 CXCL3 CXCL3 G3S4Z2_GORGO G3S4Z2_GORGO IRF8 IRF8 ALB ALB LY86 LY86 AHNAK AHNAK G3S9Y6_GORGO G3S9Y6_GORGO FAS FAS MKKS MKKS POU2AF1 POU2AF1 CXCL5 CXCL5 SERPINB2 SERPINB2 SLC7A5 SLC7A5 ATP10D ATP10D HHEX HHEX DUSP7 DUSP7 PDE4A PDE4A MACF1 MACF1 ENSGGOP00000031193 ENSGGOP00000031193 KTN1 KTN1 ENSGGOP00000031959 ENSGGOP00000031959 LCK LCK ENSGGOP00000032988 ENSGGOP00000032988 ENSGGOP00000033800 ENSGGOP00000033800 CD68 CD68 SIPA1 SIPA1 RUNX1 RUNX1 NEU1 NEU1 CLEC10A CLEC10A CXCL11 CXCL11 TFE3 TFE3 ENSGGOP00000039398 ENSGGOP00000039398 CD82 CD82 PIK3C2B PIK3C2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AHNAK2Uncharacterized protein. (793 aa)
CD300ECD300e molecule. (204 aa)
ENSGGOP00000045646Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family. (178 aa)
TREM1IG domain-containing protein. (249 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (580 aa)
ENSGGOP00000049973Fas activated serine/threonine kinase. (553 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (423 aa)
NRIP1Nuclear receptor interacting protein 1. (1158 aa)
IFNAR2Uncharacterized protein. (519 aa)
NFATC1Nuclear factor of activated T cells 1. (948 aa)
CD8ACD8a molecule. (236 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4646 aa)
GPR171G protein-coupled receptor 171; Belongs to the G-protein coupled receptor 1 family. (319 aa)
G3QFQ4_GORGOBEN domain-containing protein. (400 aa)
CCL17C-C motif chemokine. (94 aa)
G3QHR3_GORGOIg-like domain-containing protein. (643 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
G3QI01_GORGOCAP-Gly domain containing linker protein 1. (1438 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
CD4CD4 molecule. (458 aa)
CYSLTR1Cysteinyl leukotriene receptor 1. (337 aa)
CXCL1C-X-C motif chemokine. (107 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
CCL23C-C motif chemokine. (137 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
CXCL9C-X-C motif chemokine. (125 aa)
CD27CD27 molecule. (260 aa)
IL13Interleukin 13. (170 aa)
CCL24SCY domain-containing protein. (64 aa)
FPR2N-formyl peptide receptor 2; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (By similarity). Binding of FMLP to the receptor causes activation of neutrophils (By similarity). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5- stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity). (350 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
NFKBIL1NFKB inhibitor like 1. (381 aa)
G3QT76_GORGOTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
FCARFc fragment of IgA receptor. (287 aa)
G3QTT4_GORGONeurturin. (197 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
G3QWR7_GORGONon-specific serine/threonine protein kinase. (776 aa)
G3QYB0_GORGOTNF receptor superfamily member 10d. (386 aa)
CCRL2C-C motif chemokine receptor like 2; Belongs to the G-protein coupled receptor 1 family. (356 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1087 aa)
G3R063_GORGOC-X-C motif chemokine. (103 aa)
CD300LDCD300 molecule like family member d. (194 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
IL17AInterleukin 17A. (155 aa)
G3R3G6_GORGOComplement C1q A chain. (245 aa)
C1QCComplement C1q C chain. (245 aa)
VSTM1V-set and transmembrane domain containing 1. (236 aa)
G3R4Q3_GORGORuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (447 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
SCO2SCO cytochrome c oxidase assembly protein 2. (266 aa)
TOR2ATorsin. (321 aa)
ZNF785Zinc finger protein 785. (405 aa)
OASL2'-5'-oligoadenylate synthetase like. (514 aa)
LILRB4Ig-like domain-containing protein. (342 aa)
G3R9N8_GORGOUncharacterized protein. (458 aa)
DDI1DNA damage inducible 1 homolog 1. (396 aa)
G3RBD1_GORGOC-type lectin domain containing 17A. (341 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
PRCCProline rich mitotic checkpoint control factor. (491 aa)
G3RD46_GORGOCathepsin G; Belongs to the peptidase S1 family. (255 aa)
IL10Interleukin 10. (178 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CCL2C-C motif chemokine. (99 aa)
SIGLEC1Sialic acid binding Ig like lectin 1. (1709 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (285 aa)
LTC4SLeukotriene C4 synthase. (150 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
TNIP3TNFAIP3 interacting protein 3. (376 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
G3RRK1_GORGOUncharacterized protein. (497 aa)
IL6Interleukin 6. (234 aa)
G3RV54_GORGOProtein tyrosine phosphatase receptor type C. (1306 aa)
APOBApolipoprotein B. (4566 aa)
ARIH1RBR-type E3 ubiquitin transferase. (557 aa)
STAMBPSTAM binding protein. (424 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
NFKBIZNFKB inhibitor zeta. (718 aa)
SIRPASignal regulatory protein alpha. (508 aa)
ENSGGOP00000021036annotation not available (839 aa)
PPBPC-X-C motif chemokine. (128 aa)
STAMBPL1STAM binding protein like 1. (461 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
CEACAM1Carcinoembryonic antigen related cell adhesion molecule 1. (525 aa)
CXCL3C-X-C motif chemokine. (107 aa)
G3S4Z2_GORGOUncharacterized protein. (119 aa)
IRF8Interferon regulatory factor 8. (426 aa)
ALBAlbumin. (609 aa)
LY86Lymphocyte antigen 86. (162 aa)
AHNAKPDZ domain-containing protein. (5891 aa)
G3S9Y6_GORGOThioredoxin domain-containing protein. (93 aa)
FASFas cell surface death receptor. (340 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
POU2AF1POU class 2 homeobox associating factor 1. (256 aa)
CXCL5C-X-C motif chemokine. (114 aa)
SERPINB2Serpin family B member 2; Belongs to the serpin family. (415 aa)
SLC7A5Solute carrier family 7 member 5. (507 aa)
ATP10DPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1426 aa)
HHEXHomeobox domain-containing protein. (98 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (349 aa)
PDE4APhosphodiesterase. (886 aa)
MACF1Uncharacterized protein. (7590 aa)
ENSGGOP00000031193Uncharacterized protein. (93 aa)
KTN1Kinectin 1. (1214 aa)
ENSGGOP00000031959Thioredoxin domain-containing protein. (106 aa)
LCKTyrosine-protein kinase. (524 aa)
ENSGGOP00000032988annotation not available (98 aa)
ENSGGOP00000033800Tetraspanin. (266 aa)
CD68CD68 molecule. (354 aa)
SIPA1Signal-induced proliferation-associated 1. (1042 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
NEU1Neuraminidase 1. (417 aa)
CLEC10AC-type lectin domain-containing protein. (254 aa)
CXCL11C-X-C motif chemokine. (94 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (575 aa)
ENSGGOP00000039398Uncharacterized protein. (100 aa)
CD82Tetraspanin. (266 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1636 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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