STRINGSTRING
ENSGGOP00000021036 ENSGGOP00000021036 ENSGGOP00000045267 ENSGGOP00000045267 ENSGGOP00000046758 ENSGGOP00000046758 TLR4 TLR4 G3R8R1_GORGO G3R8R1_GORGO IL6 IL6 G3QT76_GORGO G3QT76_GORGO IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSGGOP00000021036annotation not available (839 aa)
ENSGGOP00000045267Uncharacterized protein; Belongs to the peptidase C14A family. (342 aa)
ENSGGOP00000046758Caspase 1; Belongs to the peptidase C14A family. (404 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
G3R8R1_GORGOCaspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (341 aa)
IL6Interleukin 6. (234 aa)
G3QT76_GORGOTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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