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ACO2 ACO2 PDHX PDHX PARP8 PARP8 SUCLG1 SUCLG1 G3QI31_GORGO G3QI31_GORGO IDH3A IDH3A DLAT DLAT GOT1 GOT1 PPM1K PPM1K GCDH GCDH NIT2 NIT2 IDH2 IDH2 GOT2 GOT2 PDK3 PDK3 SUCLA2 SUCLA2 IDH3B IDH3B IL4I1 IL4I1 LDHD LDHD HACL1 HACL1 ME2 ME2 DLST DLST MDH2 MDH2 IDH1 IDH1 G3RB77_GORGO G3RB77_GORGO PDHB PDHB G3RCP9_GORGO G3RCP9_GORGO PDHA2 PDHA2 GOT1L1 GOT1L1 G3REG2_GORGO G3REG2_GORGO PC PC G3RGX1_GORGO G3RGX1_GORGO PDK2 PDK2 LDHB LDHB ACO1 ACO1 G3RPH6_GORGO G3RPH6_GORGO G3RR71_GORGO G3RR71_GORGO G3RRJ9_GORGO G3RRJ9_GORGO SUCLG2 SUCLG2 G3S0B2_GORGO G3S0B2_GORGO G3S3Q5_GORGO G3S3Q5_GORGO CS CS LDHAL6B LDHAL6B PDP1 PDP1 DDO DDO BCAT1 BCAT1 BCKDHB BCKDHB ENSGGOP00000029632 ENSGGOP00000029632 TST TST MPST MPST PDK1 PDK1 ENSGGOP00000033095 ENSGGOP00000033095 PDHA1 PDHA1 LDHC LDHC ENSGGOP00000036404 ENSGGOP00000036404 MDH1 MDH1 DHTKD1 DHTKD1 OGDH OGDH LDHAL6A LDHAL6A DLD DLD ENSGGOP00000044363 ENSGGOP00000044363 ENSGGOP00000046396 ENSGGOP00000046396 ENSGGOP00000047839 ENSGGOP00000047839 ENSGGOP00000048087 ENSGGOP00000048087 ENSGGOP00000049142 ENSGGOP00000049142 ME3 ME3 ENSGGOP00000049961 ENSGGOP00000049961 OGDHL OGDHL ENSGGOP00000051025 ENSGGOP00000051025 ENSGGOP00000051824 ENSGGOP00000051824 ENSGGOP00000051851 ENSGGOP00000051851 IDH3G IDH3G
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (780 aa)
PDHXDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (501 aa)
PARP8Poly [ADP-ribose] polymerase. (837 aa)
SUCLG1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (346 aa)
G3QI31_GORGOMalate dehydrogenase 1B. (500 aa)
IDH3AIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (366 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (645 aa)
GOT1Aspartate aminotransferase. (413 aa)
PPM1KProtein phosphatase, Mg2+/Mn2+ dependent 1K. (372 aa)
GCDHGlutaryl-CoA dehydrogenase. (437 aa)
NIT2Nitrilase family member 2. (306 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
GOT2Aspartate aminotransferase. (430 aa)
PDK3Protein-serine/threonine kinase. (423 aa)
SUCLA2Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (463 aa)
IDH3BIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)
IL4I1Amine oxidase. (589 aa)
LDHDLactate dehydrogenase D. (484 aa)
HACL12-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (578 aa)
ME2Malic enzyme. (584 aa)
DLSTDihydrolipoamide S-succinyltransferase. (453 aa)
MDH2Malate dehydrogenase. (338 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
G3RB77_GORGO2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (448 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
G3RCP9_GORGODihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (507 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (388 aa)
GOT1L1Glutamic-oxaloacetic transaminase 1 like 1. (421 aa)
G3REG2_GORGOGlutamic--pyruvic transaminase. (496 aa)
PCPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1178 aa)
G3RGX1_GORGOL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (291 aa)
ACO1Aconitase 1; Belongs to the aconitase/IPM isomerase family. (889 aa)
G3RPH6_GORGOL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (359 aa)
G3RR71_GORGOMalic enzyme. (545 aa)
G3RRJ9_GORGOPyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (428 aa)
SUCLG2Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (440 aa)
G3S0B2_GORGOL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (358 aa)
G3S3Q5_GORGOUncharacterized protein. (706 aa)
CSCitrate synthase; Belongs to the citrate synthase family. (466 aa)
LDHAL6BL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
PDP1Pyruvate dehyrogenase phosphatase catalytic subunit 1. (596 aa)
DDOD-aspartate oxidase. (369 aa)
BCAT1Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (420 aa)
BCKDHBBranched chain keto acid dehydrogenase E1 subunit beta. (343 aa)
ENSGGOP00000029632L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (340 aa)
TSTRhodanese domain-containing protein. (243 aa)
MPSTSulfurtransferase. (317 aa)
PDK1Protein-serine/threonine kinase. (456 aa)
ENSGGOP00000033095Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (403 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform X1. (109 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
ENSGGOP00000036404Uncharacterized protein. (648 aa)
MDH1Malate dehydrogenase. (352 aa)
DHTKD1Dehydrogenase E1 and transketolase domain containing 1. (919 aa)
OGDHOxoglutarate dehydrogenase. (1018 aa)
LDHAL6AL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
DLDDihydrolipoyl dehydrogenase. (515 aa)
ENSGGOP00000044363Iso_dh domain-containing protein. (65 aa)
ENSGGOP00000046396Uncharacterized protein. (74 aa)
ENSGGOP00000047839L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (351 aa)
ENSGGOP00000048087Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (445 aa)
ENSGGOP00000049142ATP-grasp_2 domain-containing protein. (350 aa)
ME3Malic enzyme. (604 aa)
ENSGGOP00000049961Uncharacterized protein; Belongs to the LDH/MDH superfamily. (308 aa)
OGDHLOxoglutarate dehydrogenase like. (1019 aa)
ENSGGOP00000051025Aminotran_1_2 domain-containing protein. (389 aa)
ENSGGOP00000051824Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (415 aa)
ENSGGOP00000051851Uncharacterized protein; Belongs to the LDH/MDH superfamily. (336 aa)
IDH3GIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (393 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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