(84 nodes) Mixed, incl. Rho protein signal transduction, and RHOJ GTPase cycle network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AKAP13	A-kinase anchoring protein 13. (2817 aa)
	ST6GALNAC6	Uncharacterized protein. (86 aa)
	FMNL3	Formin like 3. (1027 aa)
	KALRN	Uncharacterized protein. (2986 aa)
	DIAPH3	Diaphanous related formin 3. (1193 aa)
	G3QI01_GORGO	CAP-Gly domain containing linker protein 1. (1438 aa)
	PLEK2	Pleckstrin 2. (356 aa)
	IQGAP3	IQ motif containing GTPase activating protein 3. (1632 aa)
	PAK1	Non-specific serine/threonine protein kinase. (554 aa)
	DOCK4	Dedicator of cytokinesis 4; Belongs to the DOCK family. (1986 aa)
	RHOBTB3	Rho related BTB domain containing 3. (611 aa)
	G3QPY2_GORGO	Uncharacterized protein. (1173 aa)
	BNIP2	BCL2 interacting protein 2. (433 aa)
	ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
	RHOU	Uncharacterized protein. (177 aa)
	RHOJ	Ras homolog family member J. (214 aa)
	G3QY69_GORGO	DM1 protein kinase. (656 aa)
	TNK2	Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1086 aa)
	ARHGDIB	Rho GDP dissociation inhibitor beta. (201 aa)
	GIT2	GIT ArfGAP 2. (760 aa)
	GNA12	G protein subunit alpha 12. (381 aa)
	ARHGDIG	Rho GDP dissociation inhibitor gamma. (217 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	THY1	Thy-1 cell surface antigen. (161 aa)
	RAC3	Rac family small GTPase 3. (180 aa)
	ELMO3	Engulfment and cell motility 3. (773 aa)
	RHOA	Uncharacterized protein. (179 aa)
	G3RCS6_GORGO	Trio Rho guanine nucleotide exchange factor. (2867 aa)
	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa)
	ELMO2	Engulfment and cell motility 2. (720 aa)
	RTKN	Rhotekin. (563 aa)
	MYO9A	Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2548 aa)
	DOCK11	Dedicator of cytokinesis 11; Belongs to the DOCK family. (2016 aa)
	ARHGAP10	Rho GTPase activating protein 10. (786 aa)
	RHOD	Ras homolog family member D. (210 aa)
	DOCK1	Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa)
	ARHGEF1	Rho guanine nucleotide exchange factor 1. (948 aa)
	ARHGEF28	Rho guanine nucleotide exchange factor 28. (1700 aa)
	ELMO1	Engulfment and cell motility 1. (727 aa)
	ARHGAP1	Rho GTPase activating protein 1. (439 aa)
	G3RYA7_GORGO	Uncharacterized protein. (382 aa)
	G3S7N0_GORGO	Uncharacterized protein. (232 aa)
	CLRN2	Clarin 2. (232 aa)
	MYO9B	Myosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2159 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1562 aa)
	ARHGAP5	Rho GTPase activating protein 5. (1502 aa)
	CGNL1	Cingulin like 1. (1305 aa)
	PLEKHG5	Pleckstrin homology and RhoGEF domain containing G5. (1063 aa)
	G3SKN5_GORGO	Dedicator of cytokinesis 2; Belongs to the DOCK family. (1698 aa)
	RGS8	Regulator of G protein signaling 8. (198 aa)
	ARHGEF7	Rho guanine nucleotide exchange factor 7. (803 aa)
	RND2	Uncharacterized protein. (276 aa)
	RHOB	Ras homolog family member B. (196 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	RAC1	Rac family small GTPase 1. (211 aa)
	PREX1	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1658 aa)
	RND3	Rho family GTPase 3. (244 aa)
	MCF2	MCF.2 cell line derived transforming sequence. (1001 aa)
	ENSGGOP00000039174	Uncharacterized protein. (417 aa)
	ENSGGOP00000039941	Uncharacterized protein. (205 aa)
	ENSGGOP00000040139	Uncharacterized protein. (86 aa)
	ENSGGOP00000040427	Rho GDP dissociation inhibitor alpha. (235 aa)
	CIT	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2075 aa)
	DOCK9	Dedicator of cytokinesis 9; Belongs to the DOCK family. (2099 aa)
	IQGAP2	IQ motif containing GTPase activating protein 2. (1575 aa)
	ENSGGOP00000042608	Uncharacterized protein. (190 aa)
	CDC42	Cell division cycle 42. (191 aa)
	ENSGGOP00000044154	Uncharacterized protein. (185 aa)
	ARHGEF3	Rho guanine nucleotide exchange factor 3. (558 aa)
	CGN	Myosin_tail_1 domain-containing protein. (1210 aa)
	ENSGGOP00000044572	Diaphanous related formin 1. (1242 aa)
	ARHGAP35	Rho GTPase activating protein 35. (1499 aa)
	ENSGGOP00000044876	Uncharacterized protein. (192 aa)
	ENSGGOP00000045477	Non-specific serine/threonine protein kinase. (530 aa)
	RHOG	Ras homolog family member G. (191 aa)
	ENSGGOP00000047465	P21 (RAC1) activated kinase 3. (580 aa)
	ENSGGOP00000047684	DHR-2 domain-containing protein; Belongs to the DOCK family. (430 aa)
	ENSGGOP00000047810	DHR-1 domain-containing protein; Belongs to the DOCK family. (132 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1504 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1657 aa)
	GIT1	GIT ArfGAP 1. (770 aa)
	ENSGGOP00000050077	Formin binding protein 1 like. (611 aa)
	RHOC	Ras homolog family member C. (193 aa)
	ENSGGOP00000051746	Uncharacterized protein. (154 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP13	ARHGEF1	ENSGGOP00000000766	ENSGGOP00000014920	A-kinase anchoring protein 13.	Rho guanine nucleotide exchange factor 1.	0.937
AKAP13	ARHGEF11	ENSGGOP00000000766	ENSGGOP00000026132	A-kinase anchoring protein 13.	Rho guanine nucleotide exchange factor 11.	0.934
AKAP13	ARHGEF12	ENSGGOP00000000766	ENSGGOP00000048642	A-kinase anchoring protein 13.	Rho guanine nucleotide exchange factor 12.	0.585
AKAP13	CDC42	ENSGGOP00000000766	ENSGGOP00000043168	A-kinase anchoring protein 13.	Cell division cycle 42.	0.579
AKAP13	ENSGGOP00000039941	ENSGGOP00000000766	ENSGGOP00000039941	A-kinase anchoring protein 13.	Uncharacterized protein.	0.414
AKAP13	ENSGGOP00000042608	ENSGGOP00000000766	ENSGGOP00000042608	A-kinase anchoring protein 13.	Uncharacterized protein.	0.421
AKAP13	ENSGGOP00000044154	ENSGGOP00000000766	ENSGGOP00000044154	A-kinase anchoring protein 13.	Uncharacterized protein.	0.421
AKAP13	ENSGGOP00000051746	ENSGGOP00000000766	ENSGGOP00000051746	A-kinase anchoring protein 13.	Uncharacterized protein.	0.414
AKAP13	G3RCS6_GORGO	ENSGGOP00000000766	ENSGGOP00000013310	A-kinase anchoring protein 13.	Trio Rho guanine nucleotide exchange factor.	0.423
AKAP13	GNA12	ENSGGOP00000000766	ENSGGOP00000009263	A-kinase anchoring protein 13.	G protein subunit alpha 12.	0.964
AKAP13	GNA13	ENSGGOP00000000766	ENSGGOP00000009816	A-kinase anchoring protein 13.	G protein subunit alpha 13.	0.945
AKAP13	KALRN	ENSGGOP00000000766	ENSGGOP00000001581	A-kinase anchoring protein 13.	Uncharacterized protein.	0.423
AKAP13	MCF2	ENSGGOP00000000766	ENSGGOP00000039004	A-kinase anchoring protein 13.	MCF.2 cell line derived transforming sequence.	0.637
AKAP13	PLEK2	ENSGGOP00000000766	ENSGGOP00000002128	A-kinase anchoring protein 13.	Pleckstrin 2.	0.446
AKAP13	RAC1	ENSGGOP00000000766	ENSGGOP00000034137	A-kinase anchoring protein 13.	Rac family small GTPase 1.	0.421
AKAP13	RAC3	ENSGGOP00000000766	ENSGGOP00000011318	A-kinase anchoring protein 13.	Rac family small GTPase 3.	0.421
AKAP13	RHOA	ENSGGOP00000000766	ENSGGOP00000012527	A-kinase anchoring protein 13.	Uncharacterized protein.	0.999
AKAP13	RHOB	ENSGGOP00000000766	ENSGGOP00000030556	A-kinase anchoring protein 13.	Ras homolog family member B.	0.720
AKAP13	RHOBTB3	ENSGGOP00000000766	ENSGGOP00000004247	A-kinase anchoring protein 13.	Rho related BTB domain containing 3.	0.414
AKAP13	RHOC	ENSGGOP00000000766	ENSGGOP00000051168	A-kinase anchoring protein 13.	Ras homolog family member C.	0.782