(11 nodes) ERBB2-EGFR signaling pathway, and Neuregulin binding network (Gorilla gorilla)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	EREG	EGF-like domain-containing protein. (222 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1183 aa)
	G3QZR8_GORGO	Uncharacterized protein. (533 aa)
	BTC	Betacellulin. (178 aa)
	AREG	EGF-like domain-containing protein. (274 aa)
	ENSGGOP00000034632	Recep_L_domain domain-containing protein. (183 aa)
	ERBB3	Protein kinase domain-containing protein. (593 aa)
	EGFR	Receptor protein-tyrosine kinase. (1205 aa)
	TGFA	Transforming growth factor alpha. (166 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AREG	BTC	ENSGGOP00000021852	ENSGGOP00000013476	EGF-like domain-containing protein.	Betacellulin.	0.932
AREG	EGF	ENSGGOP00000021852	ENSGGOP00000005698	EGF-like domain-containing protein.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.945
AREG	EGFR	ENSGGOP00000021852	ENSGGOP00000041101	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.997
AREG	ENSGGOP00000034632	ENSGGOP00000021852	ENSGGOP00000034632	EGF-like domain-containing protein.	Recep_L_domain domain-containing protein.	0.778
AREG	ERBB2	ENSGGOP00000021852	ENSGGOP00000004424	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.934
AREG	ERBB3	ENSGGOP00000021852	ENSGGOP00000037530	EGF-like domain-containing protein.	Protein kinase domain-containing protein.	0.919
AREG	EREG	ENSGGOP00000021852	ENSGGOP00000003745	EGF-like domain-containing protein.	EGF-like domain-containing protein.	0.950
AREG	G3QZR8_GORGO	ENSGGOP00000021852	ENSGGOP00000008384	EGF-like domain-containing protein.	Uncharacterized protein.	0.596
AREG	HBEGF	ENSGGOP00000021852	ENSGGOP00000000281	EGF-like domain-containing protein.	Heparin binding EGF like growth factor.	0.678
AREG	TGFA	ENSGGOP00000021852	ENSGGOP00000045108	EGF-like domain-containing protein.	Transforming growth factor alpha.	0.788
BTC	AREG	ENSGGOP00000013476	ENSGGOP00000021852	Betacellulin.	EGF-like domain-containing protein.	0.932
BTC	EGF	ENSGGOP00000013476	ENSGGOP00000005698	Betacellulin.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.852
BTC	EGFR	ENSGGOP00000013476	ENSGGOP00000041101	Betacellulin.	Receptor protein-tyrosine kinase.	0.994
BTC	ENSGGOP00000034632	ENSGGOP00000013476	ENSGGOP00000034632	Betacellulin.	Recep_L_domain domain-containing protein.	0.767
BTC	ERBB2	ENSGGOP00000013476	ENSGGOP00000004424	Betacellulin.	Receptor protein-tyrosine kinase.	0.758
BTC	ERBB3	ENSGGOP00000013476	ENSGGOP00000037530	Betacellulin.	Protein kinase domain-containing protein.	0.767
BTC	EREG	ENSGGOP00000013476	ENSGGOP00000003745	Betacellulin.	EGF-like domain-containing protein.	0.705
BTC	G3QZR8_GORGO	ENSGGOP00000013476	ENSGGOP00000008384	Betacellulin.	Uncharacterized protein.	0.654
BTC	HBEGF	ENSGGOP00000013476	ENSGGOP00000000281	Betacellulin.	Heparin binding EGF like growth factor.	0.891
BTC	TGFA	ENSGGOP00000013476	ENSGGOP00000045108	Betacellulin.	Transforming growth factor alpha.	0.649