(31 nodes) Mixed, incl. CD28 dependent PI3K/Akt signaling, and Ribosomal protein S6 kinase activity network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPS6KA1	Ribosomal protein S6 kinase. (744 aa)
	DEPTOR	DEP domain containing MTOR interacting protein. (409 aa)
	PHLPP1	PH domain and leucine rich repeat protein phosphatase 1. (1720 aa)
	MAPKAP1	MAPK associated protein 1. (522 aa)
	G3QVR1_GORGO	SMG1_N domain-containing protein. (562 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	RHEBL1	RHEB like 1. (183 aa)
	RPS6KA3	Ribosomal protein S6 kinase. (740 aa)
	RPS6KB2	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
	G3REQ0_GORGO	Uncharacterized protein. (1222 aa)
	CRYGN	Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (182 aa)
	RHEB	Ras homolog, mTORC1 binding. (184 aa)
	RPS6KB1	Protein kinase domain-containing protein. (210 aa)
	TSC2	TSC complex subunit 2. (1806 aa)
	G3RXW1_GORGO	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (372 aa)
	AKT1S1	AKT1 substrate 1. (276 aa)
	RICTOR	RPTOR independent companion of MTOR complex 2. (1732 aa)
	PHLPP2	PH domain and leucine rich repeat protein phosphatase 2. (1344 aa)
	MLST8	MTOR associated protein, LST8 homolog. (326 aa)
	TSC1	TSC complex subunit 1. (1164 aa)
	FKBP8	Peptidylprolyl isomerase. (413 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	ENSGGOP00000033233	TBC1 domain family member 7. (293 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (758 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1288 aa)
	DDIT4	DNA damage inducible transcript 4. (232 aa)
	ENSGGOP00000046735	Non-specific serine/threonine protein kinase. (524 aa)
	ENSGGOP00000047870	TPR_REGION domain-containing protein. (251 aa)
	ENSGGOP00000051208	DUF3384 domain-containing protein. (525 aa)
	ENSGGOP00000051551	Proline rich 5. (372 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1S1	AKT2	ENSGGOP00000023242	ENSGGOP00000033032	AKT1 substrate 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.973
AKT1S1	AKT3	ENSGGOP00000023242	ENSGGOP00000007562	AKT1 substrate 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.971
AKT1S1	CRYGN	ENSGGOP00000023242	ENSGGOP00000014306	AKT1 substrate 1.	Uncharacterized protein; Belongs to the beta/gamma-crystallin family.	0.538
AKT1S1	DEPTOR	ENSGGOP00000023242	ENSGGOP00000004308	AKT1 substrate 1.	DEP domain containing MTOR interacting protein.	0.986
AKT1S1	ENSGGOP00000046735	ENSGGOP00000023242	ENSGGOP00000046735	AKT1 substrate 1.	Non-specific serine/threonine protein kinase.	0.922
AKT1S1	ENSGGOP00000047870	ENSGGOP00000023242	ENSGGOP00000047870	AKT1 substrate 1.	TPR_REGION domain-containing protein.	0.699
AKT1S1	ENSGGOP00000051208	ENSGGOP00000023242	ENSGGOP00000051208	AKT1 substrate 1.	DUF3384 domain-containing protein.	0.442
AKT1S1	ENSGGOP00000051551	ENSGGOP00000023242	ENSGGOP00000051551	AKT1 substrate 1.	Proline rich 5.	0.557
AKT1S1	FKBP8	ENSGGOP00000023242	ENSGGOP00000029141	AKT1 substrate 1.	Peptidylprolyl isomerase.	0.699
AKT1S1	G3QVR1_GORGO	ENSGGOP00000023242	ENSGGOP00000006842	AKT1 substrate 1.	SMG1_N domain-containing protein.	0.706
AKT1S1	MAPKAP1	ENSGGOP00000023242	ENSGGOP00000005822	AKT1 substrate 1.	MAPK associated protein 1.	0.966
AKT1S1	MLST8	ENSGGOP00000023242	ENSGGOP00000026281	AKT1 substrate 1.	MTOR associated protein, LST8 homolog.	0.999
AKT1S1	MTOR	ENSGGOP00000023242	ENSGGOP00000010372	AKT1 substrate 1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.999
AKT1S1	RHEB	ENSGGOP00000023242	ENSGGOP00000014313	AKT1 substrate 1.	Ras homolog, mTORC1 binding.	0.986
AKT1S1	RHEBL1	ENSGGOP00000023242	ENSGGOP00000007807	AKT1 substrate 1.	RHEB like 1.	0.555
AKT1S1	RICTOR	ENSGGOP00000023242	ENSGGOP00000023872	AKT1 substrate 1.	RPTOR independent companion of MTOR complex 2.	0.884
AKT1S1	RPS6KA1	ENSGGOP00000023242	ENSGGOP00000002886	AKT1 substrate 1.	Ribosomal protein S6 kinase.	0.445
AKT1S1	RPS6KB1	ENSGGOP00000023242	ENSGGOP00000019074	AKT1 substrate 1.	Protein kinase domain-containing protein.	0.978
AKT1S1	RPS6KB2	ENSGGOP00000023242	ENSGGOP00000009763	AKT1 substrate 1.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.965
AKT1S1	RPTOR	ENSGGOP00000023242	ENSGGOP00000041013	AKT1 substrate 1.	Regulatory associated protein of MTOR complex 1.	0.999