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| | BIK | BCL2 interacting killer. (160 aa) |
| | CARD8 | Caspase recruitment domain family member 8. (522 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | G3QHL6_GORGO | Interleukin 1 receptor associated kinase 2. (538 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (446 aa) |
| | CARD16 | Caspase recruitment domain family member 16. (197 aa) |
| | TRAF1 | TNF receptor-associated factor. (416 aa) |
| | TANK | TRAF family member associated NFKB activator. (425 aa) |
| | NFKBIB | NFKB inhibitor beta. (356 aa) |
| | NLRC4 | NLR family CARD domain containing 4. (1024 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | CARD18 | Caspase recruitment domain family member 18. (90 aa) |
| | NLRX1 | NLR family member X1. (975 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (790 aa) |
| | BCL2L10 | Uncharacterized protein. (204 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (452 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa) |
| | GSDMC | Gasdermin C. (507 aa) |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14. (947 aa) |
| | RIPK3 | Receptor interacting serine/threonine kinase 3. (518 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1028 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | DIABLO | Uncharacterized protein. (166 aa) |
| | DHX58 | DExH-box helicase 58. (678 aa) |
| | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8. (467 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (604 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | RNF135 | Ring finger protein 135. (372 aa) |
| | IFI16 | Interferon gamma inducible protein 16. (785 aa) |
| | AIM2 | Absent in melanoma 2. (343 aa) |
| | HRK | Activator of apoptosis harakiri; Promotes apoptosis. (91 aa) |
| | G3QUW7_GORGO | TIR domain-containing adapter molecule 1. (563 aa) |
| | G3QV30_GORGO | Gasdermin D. (532 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (762 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (902 aa) |
| | TRAF2 | TNF receptor-associated factor. (451 aa) |
| | BIRC8 | Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. (236 aa) |
| | NLRP2 | NLR family pyrin domain containing 2. (1040 aa) |
| | SP100 | Nuclear autoantigen Sp-100; Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regul [...] (209 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | G3QYB0_GORGO | TNF receptor superfamily member 10d. (386 aa) |
| | CD180 | CD180 molecule. (661 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (618 aa) |
| | BIRC7 | Baculoviral IAP repeat containing 7. (298 aa) |
| | CYLD | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa) |
| | NLRP12 | NLR family pyrin domain containing 12. (1065 aa) |
| | NFKBIE | ANK_REP_REGION domain-containing protein. (361 aa) |
| | CHUK | IKKbetaNEMObind domain-containing protein. (434 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | NLRC5 | NLR family CARD domain containing 5. (1866 aa) |
| | G3R3U7_GORGO | Mitochondrial antiviral signaling protein. (481 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (217 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa) |
| | NLRP7 | NLR family pyrin domain containing 7. (1037 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1040 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa) |
| | ZBP1 | Z-DNA binding protein 1. (429 aa) |
| | TNFRSF10B | TNF receptor superfamily member 10b. (440 aa) |
| | NLRP1 | NLR family pyrin domain containing 1. (1471 aa) |
| | TRIM25 | Tripartite motif containing 25. (630 aa) |
| | TRADD | Death domain-containing protein. (251 aa) |
| | G3R8R1_GORGO | Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (341 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (523 aa) |
| | TLR8 | Toll like receptor 8; Belongs to the Toll-like receptor family. (1059 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | DFFA | DNA fragmentation factor subunit alpha. (331 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa) |
| | PELI3 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa) |
| | DFFB | DNA fragmentation factor subunit beta. (338 aa) |
| | PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) |
| | GLMP | Glycosylated lysosomal membrane protein. (406 aa) |
| | DDX41 | DEAD-box helicase 41. (622 aa) |
| | LY96 | Lymphocyte antigen 96. (160 aa) |
| | G3RI71_GORGO | NACHT domain-containing protein. (1127 aa) |
| | CASP5 | Caspase 5; Belongs to the peptidase C14A family. (447 aa) |
| | MEFV | MEFV innate immuity regulator, pyrin. (781 aa) |
| | G3RID2_GORGO | TIR domain-containing protein. (1033 aa) |
| | HMGB2 | High mobility group box 2. (208 aa) |
| | IFIH1 | Interferon induced with helicase C domain 1. (1025 aa) |
| | MCL1 | MCL1 apoptosis regulator, BCL2 family member. (350 aa) |
| | STING1 | Transmembrane protein 173. (379 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | ZRANB1 | Zinc finger RANBP2-type containing 1. (734 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | DPP9 | Dipeptidyl peptidase 9; Belongs to the peptidase S9B family. (892 aa) |
| | TNIP3 | TNFAIP3 interacting protein 3. (376 aa) |
| | ALPK1 | Alpha kinase 1. (1244 aa) |
| | G3RQE7_GORGO | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (712 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | TIRAP | TIR domain containing adaptor protein. (221 aa) |
| | RELB | RELB proto-oncogene, NF-kB subunit. (579 aa) |
| | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | SQSTM1 | Sequestosome 1. (440 aa) |
| | TLR7 | Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (579 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | ENSGGOP00000021036 | annotation not available (839 aa) |
| | CRADD | CASP2 and RIPK1 domain containing adaptor with death domain. (199 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | TLR10 | Toll-like receptor. (811 aa) |
| | UNC93B1 | Uncharacterized protein. (407 aa) |
| | DDX58 | DExD/H-box helicase 58. (925 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | LY86 | Lymphocyte antigen 86. (162 aa) |
| | FASLG | Fas ligand; Belongs to the tumor necrosis factor family. (280 aa) |
| | CGAS | Cyclic GMP-AMP synthase. (447 aa) |
| | G3SE49_GORGO | NLR family pyrin domain containing 9. (934 aa) |
| | G3SE93_GORGO | REL proto-oncogene, NF-kB subunit. (619 aa) |
| | FAS | Fas cell surface death receptor. (340 aa) |
| | HMGB1 | Uncharacterized protein. (215 aa) |
| | TLR3 | Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa) |
| | CASP6 | Caspase 6; Belongs to the peptidase C14A family. (293 aa) |
| | ENSGGOP00000029090 | Uncharacterized protein. (195 aa) |
| | ENSGGOP00000029367 | Pyrin domain-containing protein. (110 aa) |
| | PIDD1 | P53-induced death domain protein 1. (910 aa) |
| | PEA15 | Proliferation and apoptosis adaptor protein 15. (151 aa) |
| | ENSGGOP00000031130 | Uncharacterized protein. (189 aa) |
| | ENSGGOP00000031193 | Uncharacterized protein. (93 aa) |
| | ENSGGOP00000031801 | CCHC NOA-type domain-containing protein. (346 aa) |
| | ENSGGOP00000032091 | Caspase 4; Belongs to the peptidase C14A family. (377 aa) |
| | ENSGGOP00000032596 | CCHC NOA-type domain-containing protein. (417 aa) |
| | ENSGGOP00000033404 | Caspase 8; Belongs to the peptidase C14A family. (496 aa) |
| | PELI2 | Pellino E3 ubiquitin protein ligase family member 2. (394 aa) |
| | GSDMB | Gasdermin B. (416 aa) |
| | TIFA | TRAF interacting protein with forkhead associated domain. (184 aa) |
| | MLKL | Uncharacterized protein. (178 aa) |
| | BCL2A1 | BCL2 related protein A1. (196 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | ENSGGOP00000035952 | TNF receptor-associated factor. (485 aa) |
| | ENSGGOP00000039123 | CCHC NOA-type domain-containing protein. (371 aa) |
| | BAD | BCL2 associated agonist of cell death. (168 aa) |
| | ENSGGOP00000040771 | Uncharacterized protein. (173 aa) |
| | BMF | Bcl2 modifying factor. (184 aa) |
| | ENSGGOP00000041058 | annotation not available (54 aa) |
| | TNIP1 | TNFAIP3 interacting protein 1. (645 aa) |
| | ENSGGOP00000043564 | Interferon regulatory factor 3. (452 aa) |
| | IRF7 | Interferon regulatory factor 7. (516 aa) |
| | CASP7 | Caspase 7; Belongs to the peptidase C14A family. (388 aa) |
| | ENSGGOP00000045267 | Uncharacterized protein; Belongs to the peptidase C14A family. (342 aa) |
| | NLRP6 | Uncharacterized protein. (912 aa) |
| | BOK | BCL2 family apoptosis regulator BOK. (212 aa) |
| | ENSGGOP00000046758 | Caspase 1; Belongs to the peptidase C14A family. (404 aa) |
| | TNFRSF10A | TNF receptor superfamily member 10a. (468 aa) |
| | G3RF33_GORGO | Tumor necrosis factor ligand superfamily member. (281 aa) |
| | RTL10 | Retrotransposon Gag like 10. (361 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa) |
| | BIRC6 | Baculoviral IAP repeat containing 6. (4883 aa) |
| | ENSGGOP00000049412 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa) |
| | ENSGGOP00000049938 | Uncharacterized protein. (177 aa) |
| | BBC3 | Uncharacterized protein. (101 aa) |
| | TNFRSF10C | TNF receptor superfamily member 10c. (284 aa) |
