STRINGSTRING
BIK BIK CARD8 CARD8 BCL2 BCL2 G3QHL6_GORGO G3QHL6_GORGO CASP9 CASP9 CARD16 CARD16 TRAF1 TRAF1 TANK TANK NFKBIB NFKBIB NLRC4 NLRC4 TLR2 TLR2 CARD18 CARD18 NLRX1 NLRX1 TNFAIP3 TNFAIP3 BCL2L10 BCL2L10 CASP2 CASP2 MYD88 MYD88 TRAF3 TRAF3 GSDMC GSDMC MAP3K14 MAP3K14 RIPK3 RIPK3 NLRP3 NLRP3 IKBKG IKBKG DIABLO DIABLO DHX58 DHX58 MAP3K8 MAP3K8 BIRC3 BIRC3 TRAF6 TRAF6 RNF135 RNF135 IFI16 IFI16 AIM2 AIM2 HRK HRK G3QUW7_GORGO G3QUW7_GORGO G3QV30_GORGO G3QV30_GORGO IKBKB IKBKB NFKB2 NFKB2 TRAF2 TRAF2 BIRC8 BIRC8 NLRP2 NLRP2 SP100 SP100 TAB1 TAB1 G3QYB0_GORGO G3QYB0_GORGO CD180 CD180 BIRC2 BIRC2 BIRC7 BIRC7 CYLD CYLD NLRP12 NLRP12 NFKBIE NFKBIE CHUK CHUK NFKBIA NFKBIA NLRC5 NLRC5 G3R3U7_GORGO G3R3U7_GORGO BAX BAX CD14 CD14 NLRP7 NLRP7 BID BID NOD2 NOD2 RIPK2 RIPK2 CFLAR CFLAR ZBP1 ZBP1 TNFRSF10B TNFRSF10B NLRP1 NLRP1 TRIM25 TRIM25 TRADD TRADD G3R8R1_GORGO G3R8R1_GORGO CASP10 CASP10 TLR8 TLR8 RIPK1 RIPK1 DFFA DFFA TRAF5 TRAF5 PELI3 PELI3 DFFB DFFB PELI1 PELI1 GLMP GLMP DDX41 DDX41 LY96 LY96 G3RI71_GORGO G3RI71_GORGO CASP5 CASP5 MEFV MEFV G3RID2_GORGO G3RID2_GORGO HMGB2 HMGB2 IFIH1 IFIH1 MCL1 MCL1 STING1 STING1 TAB2 TAB2 ZRANB1 ZRANB1 PYCARD PYCARD DPP9 DPP9 TNIP3 TNIP3 ALPK1 ALPK1 G3RQE7_GORGO G3RQE7_GORGO IRAK1 IRAK1 NFKB1 NFKB1 BAK1 BAK1 TIRAP TIRAP RELB RELB TAB3 TAB3 IKBKE IKBKE FADD FADD SQSTM1 SQSTM1 TLR7 TLR7 MAP3K7 MAP3K7 TLR4 TLR4 BCL2L1 BCL2L1 IRAK4 IRAK4 ENSGGOP00000021036 ENSGGOP00000021036 CRADD CRADD NOD1 NOD1 TLR10 TLR10 UNC93B1 UNC93B1 DDX58 DDX58 TBK1 TBK1 LY86 LY86 FASLG FASLG CGAS CGAS G3SE49_GORGO G3SE49_GORGO G3SE93_GORGO G3SE93_GORGO FAS FAS HMGB1 HMGB1 TLR3 TLR3 RELA RELA CYCS CYCS CASP6 CASP6 ENSGGOP00000029090 ENSGGOP00000029090 ENSGGOP00000029367 ENSGGOP00000029367 PIDD1 PIDD1 PEA15 PEA15 ENSGGOP00000031130 ENSGGOP00000031130 ENSGGOP00000031193 ENSGGOP00000031193 ENSGGOP00000031801 ENSGGOP00000031801 ENSGGOP00000032091 ENSGGOP00000032091 ENSGGOP00000032596 ENSGGOP00000032596 ENSGGOP00000033404 ENSGGOP00000033404 PELI2 PELI2 GSDMB GSDMB TIFA TIFA MLKL MLKL BCL2A1 BCL2A1 APAF1 APAF1 ENSGGOP00000035952 ENSGGOP00000035952 ENSGGOP00000039123 ENSGGOP00000039123 BAD BAD ENSGGOP00000040771 ENSGGOP00000040771 BMF BMF ENSGGOP00000041058 ENSGGOP00000041058 TNIP1 TNIP1 ENSGGOP00000043564 ENSGGOP00000043564 IRF7 IRF7 CASP7 CASP7 ENSGGOP00000045267 ENSGGOP00000045267 NLRP6 NLRP6 BOK BOK ENSGGOP00000046758 ENSGGOP00000046758 TNFRSF10A TNFRSF10A G3RF33_GORGO G3RF33_GORGO RTL10 RTL10 BCL2L11 BCL2L11 BIRC6 BIRC6 ENSGGOP00000049412 ENSGGOP00000049412 ENSGGOP00000049938 ENSGGOP00000049938 BBC3 BBC3 TNFRSF10C TNFRSF10C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BIKBCL2 interacting killer. (160 aa)
CARD8Caspase recruitment domain family member 8. (522 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
G3QHL6_GORGOInterleukin 1 receptor associated kinase 2. (538 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (446 aa)
CARD16Caspase recruitment domain family member 16. (197 aa)
TRAF1TNF receptor-associated factor. (416 aa)
TANKTRAF family member associated NFKB activator. (425 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
NLRC4NLR family CARD domain containing 4. (1024 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
CARD18Caspase recruitment domain family member 18. (90 aa)
NLRX1NLR family member X1. (975 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
BCL2L10Uncharacterized protein. (204 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
GSDMCGasdermin C. (507 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
NLRP3NLR family pyrin domain containing 3. (1028 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
DIABLOUncharacterized protein. (166 aa)
DHX58DExH-box helicase 58. (678 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
RNF135Ring finger protein 135. (372 aa)
IFI16Interferon gamma inducible protein 16. (785 aa)
AIM2Absent in melanoma 2. (343 aa)
HRKActivator of apoptosis harakiri; Promotes apoptosis. (91 aa)
G3QUW7_GORGOTIR domain-containing adapter molecule 1. (563 aa)
G3QV30_GORGOGasdermin D. (532 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (762 aa)
NFKB2Nuclear factor kappa B subunit 2. (902 aa)
TRAF2TNF receptor-associated factor. (451 aa)
BIRC8Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. (236 aa)
NLRP2NLR family pyrin domain containing 2. (1040 aa)
SP100Nuclear autoantigen Sp-100; Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regul [...] (209 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
G3QYB0_GORGOTNF receptor superfamily member 10d. (386 aa)
CD180CD180 molecule. (661 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
NLRP12NLR family pyrin domain containing 12. (1065 aa)
NFKBIEANK_REP_REGION domain-containing protein. (361 aa)
CHUKIKKbetaNEMObind domain-containing protein. (434 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
NLRC5NLR family CARD domain containing 5. (1866 aa)
G3R3U7_GORGOMitochondrial antiviral signaling protein. (481 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
NLRP7NLR family pyrin domain containing 7. (1037 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
ZBP1Z-DNA binding protein 1. (429 aa)
TNFRSF10BTNF receptor superfamily member 10b. (440 aa)
NLRP1NLR family pyrin domain containing 1. (1471 aa)
TRIM25Tripartite motif containing 25. (630 aa)
TRADDDeath domain-containing protein. (251 aa)
G3R8R1_GORGOCaspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (341 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (523 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1059 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
DFFADNA fragmentation factor subunit alpha. (331 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
DFFBDNA fragmentation factor subunit beta. (338 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
GLMPGlycosylated lysosomal membrane protein. (406 aa)
DDX41DEAD-box helicase 41. (622 aa)
LY96Lymphocyte antigen 96. (160 aa)
G3RI71_GORGONACHT domain-containing protein. (1127 aa)
CASP5Caspase 5; Belongs to the peptidase C14A family. (447 aa)
MEFVMEFV innate immuity regulator, pyrin. (781 aa)
G3RID2_GORGOTIR domain-containing protein. (1033 aa)
HMGB2High mobility group box 2. (208 aa)
IFIH1Interferon induced with helicase C domain 1. (1025 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
STING1Transmembrane protein 173. (379 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
ZRANB1Zinc finger RANBP2-type containing 1. (734 aa)
PYCARDPYD and CARD domain containing. (195 aa)
DPP9Dipeptidyl peptidase 9; Belongs to the peptidase S9B family. (892 aa)
TNIP3TNFAIP3 interacting protein 3. (376 aa)
ALPK1Alpha kinase 1. (1244 aa)
G3RQE7_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
TIRAPTIR domain containing adaptor protein. (221 aa)
RELBRELB proto-oncogene, NF-kB subunit. (579 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
SQSTM1Sequestosome 1. (440 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (579 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
BCL2L1BCL2 like 1. (233 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
ENSGGOP00000021036annotation not available (839 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
TLR10Toll-like receptor. (811 aa)
UNC93B1Uncharacterized protein. (407 aa)
DDX58DExD/H-box helicase 58. (925 aa)
TBK1TANK binding kinase 1. (729 aa)
LY86Lymphocyte antigen 86. (162 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
CGASCyclic GMP-AMP synthase. (447 aa)
G3SE49_GORGONLR family pyrin domain containing 9. (934 aa)
G3SE93_GORGOREL proto-oncogene, NF-kB subunit. (619 aa)
FASFas cell surface death receptor. (340 aa)
HMGB1Uncharacterized protein. (215 aa)
TLR3Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (293 aa)
ENSGGOP00000029090Uncharacterized protein. (195 aa)
ENSGGOP00000029367Pyrin domain-containing protein. (110 aa)
PIDD1P53-induced death domain protein 1. (910 aa)
PEA15Proliferation and apoptosis adaptor protein 15. (151 aa)
ENSGGOP00000031130Uncharacterized protein. (189 aa)
ENSGGOP00000031193Uncharacterized protein. (93 aa)
ENSGGOP00000031801CCHC NOA-type domain-containing protein. (346 aa)
ENSGGOP00000032091Caspase 4; Belongs to the peptidase C14A family. (377 aa)
ENSGGOP00000032596CCHC NOA-type domain-containing protein. (417 aa)
ENSGGOP00000033404Caspase 8; Belongs to the peptidase C14A family. (496 aa)
PELI2Pellino E3 ubiquitin protein ligase family member 2. (394 aa)
GSDMBGasdermin B. (416 aa)
TIFATRAF interacting protein with forkhead associated domain. (184 aa)
MLKLUncharacterized protein. (178 aa)
BCL2A1BCL2 related protein A1. (196 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
ENSGGOP00000035952TNF receptor-associated factor. (485 aa)
ENSGGOP00000039123CCHC NOA-type domain-containing protein. (371 aa)
BADBCL2 associated agonist of cell death. (168 aa)
ENSGGOP00000040771Uncharacterized protein. (173 aa)
BMFBcl2 modifying factor. (184 aa)
ENSGGOP00000041058annotation not available (54 aa)
TNIP1TNFAIP3 interacting protein 1. (645 aa)
ENSGGOP00000043564Interferon regulatory factor 3. (452 aa)
IRF7Interferon regulatory factor 7. (516 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (388 aa)
ENSGGOP00000045267Uncharacterized protein; Belongs to the peptidase C14A family. (342 aa)
NLRP6Uncharacterized protein. (912 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
ENSGGOP00000046758Caspase 1; Belongs to the peptidase C14A family. (404 aa)
TNFRSF10ATNF receptor superfamily member 10a. (468 aa)
G3RF33_GORGOTumor necrosis factor ligand superfamily member. (281 aa)
RTL10Retrotransposon Gag like 10. (361 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
BIRC6Baculoviral IAP repeat containing 6. (4883 aa)
ENSGGOP00000049412Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
ENSGGOP00000049938Uncharacterized protein. (177 aa)
BBC3Uncharacterized protein. (101 aa)
TNFRSF10CTNF receptor superfamily member 10c. (284 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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